Eco-friendly synthesis and biomedical applications of gold nanoparticles: A review

Kalishwaralal, Kalimuthu; Seok, Byung; Kim, Seokjoon; Park, Ki Soo

doi:10.1016/j.microc.2019.104296

Cited by 119 publications

(62 citation statements)

References 157 publications

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“…2,3 The top-bottom approach to carve the bulk materials into their nano-forms by using the reducing and stabilizing abilities of plant secondary metabolites depends greatly on reaction conditions that can be harnessed by physicochemical parameters and influence the final size, shape, and capping of nanomaterials. [4][5][6] Physicochemical parameters provide a toolbox to carve nanoparticles and have different effects. Temperature plays a vital role by not only providing the activation energy that is usually required for the inception of a chemical reaction but also favors by increasing the molecular collision that enhances the possibility of the reactants to collide and convert into their resultant product.…”

Section: Introductionmentioning

confidence: 99%

<p>Synergistic Effects of Physicochemical Parameters on Bio-Fabrication of Mint Silver Nanoparticles: Structural Evaluation and Action Against HCT116 Colon Cancer Cells</p>

Javed¹,

Mashwani²

2020

IJN

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Background: Physicochemical parameters such as temperature, pH, the concentration of the AgNO 3 and ratio of reactants act synergistically to influence the reaction kinetics, molecular mechanics, enzymatic catalysis and protein conformations that aid to affect the size, shape and biochemical corona of nanoparticles. The present study was performed to investigate the influence of reaction parameters on the bio-fabrication of silver nanoparticles (AgNPs) by using Mentha arvensis and to determine their potential to control the proliferation of colon cancer cells'. Methods: Plant-mediated method was used for the bio-fabrication and stabilization of AgNPs. Reaction parameters were arranged, and surface plasmon resonance (SPR) bands of AgNPs were collected by using a UV-Visible spectrophotometer. NPs were characterized structurally and optically by using SEM, AFM, EDX and DLS techniques. AgNPs and plant aqueous extract were tested against HCT116 colon cancer cells by using SRB assay, Annexin V assay and cell cycle analysis. Results: Spectrophotometric comparison of various reaction conditions manifested that 5 mM of AgNO 3 , 60°C in an acidic pH and a mixing ratio of 1:9 of plant extract and AgNO 3 , respectively, are the optimized conditions for AgNP synthesis. Structural evaluation by SEM, AFM and particle size analysis confirmed that the NPs are <100 nm and are anisotropic, spherical, triangular and moderately dispersed in the colloidal mixture. SRB assay expressed biomass-stabilized AgNPs as effective cytotoxic particles against HCT116 colon cancer cells, and the IC 50 was measured at 1.7 µg/mL. Annexin V apoptosis assay further confirmed that the AgNPs induce apoptosis in a dose-dependent manner. Experimental evidence manifested that the AgNPs arrest cell cycle and expressed entrapment of a greater number of cells in the Sub-G1 phase, further verifying the anticancer abilities of AgNPs. Conclusion: These findings explain the synergistic effects of physicochemical parameters to optimize the phytosynthesis of biocompatible AgNPs to overcome the limitations of conventional chemotherapeutic treatments of colon cancer cells.

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Section: Introductionmentioning

confidence: 99%

<p>Synergistic Effects of Physicochemical Parameters on Bio-Fabrication of Mint Silver Nanoparticles: Structural Evaluation and Action Against HCT116 Colon Cancer Cells</p>

Javed¹,

Mashwani²

2020

IJN

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“…So far, GNPs have also been used for efficient colorimetric, electrochemical, enzymatic, uorescence resonance energy transfer (FRET), surface enhanced Raman scattering, and optical sensing applications. [247][248][249] GNPs have been examined for the testing of choline and uric acid. 250,251 Recently, GNPs have also been used for cardiac disease sensing, kidney malfunctioning, DNA/RNA detection, and immune-sensing (Fig.…”

Section: Bio-sensing Applicationmentioning

confidence: 99%

Role of gold nanoparticles in advanced biomedical applications

et al. 2020

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“…The enhanced surface-area-to-volume ratio makes them excellent for use as catalysts, in analytical assays, and for antimicrobial applications [1][2][3]. In particular, metal nanoparticles like Au, Ag, Ru, Pt, Rh, Pd, and Ni nanoparticles are relevant in biomedical [4], antimicrobial [5], drug delivery [6], sensing/biosensing [7]. Moreover, metal nanoparticles are used in catalytic applications [6], including for the electrocatalytical hydrogen evolution reaction [8], acidic oxygen evolution [9], and the methanation (Sabatier) reaction [10].…”

Section: Introductionmentioning

confidence: 99%

Advances in Nickel Nanoparticle Synthesis via Oleylamine Route

et al. 2020

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Nickel nanoparticles are an active research area due to their multiple applications as catalysts in different processes. A variety of preparation techniques have been reported for the synthesis of these nanoparticles, including solvothermal, microwave-assisted, and emulsion techniques. The well-studied solvothermal oleylamine synthesis route comes with the drawback of needing standard air-free techniques and often space-consuming glassware. Here, we present a facile and straightforward synthesis method for size-controlled highly monodisperse nickel nanoparticles avoiding the use of, e.g., Schlenk techniques and space-consuming labware. The nanoparticles produced by this novel synthetic route were investigated using small-angle X-ray scattering, transmission electron microscopy, X-ray diffraction, and X-ray spectroscopy. The nanoparticles were in a size range of 4–16 nm, show high sphericity, no oxidation, and no agglomeration after synthesis.

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Eco-friendly synthesis and biomedical applications of gold nanoparticles: A review

Cited by 119 publications

References 157 publications

<p>Synergistic Effects of Physicochemical Parameters on Bio-Fabrication of Mint Silver Nanoparticles: Structural Evaluation and Action Against HCT116 Colon Cancer Cells</p>

<p>Synergistic Effects of Physicochemical Parameters on Bio-Fabrication of Mint Silver Nanoparticles: Structural Evaluation and Action Against HCT116 Colon Cancer Cells</p>

Role of gold nanoparticles in advanced biomedical applications

Advances in Nickel Nanoparticle Synthesis via Oleylamine Route

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