In situ monitoring of mechanochemical reactions between dicyandiamide (DCD) and CuX2 salts (X = Cl-, NO3-), for the preparation of compounds of agrochemical interest, showed the appearance of a number...

The solubility is generally thought to be higher if the solvent effectively solvates solute molecules that are wellseparated from each other. The present work suggests, however, that the formation of large solute aggregates does not necessarily imply less effective solvation and lower solubility. Measurements of the solubility of simvastatin (one of the most commonly prescribed antihyperlipidemic drugs) in three solvents with different polarities and protic characters, led to the solubility order acetone > ethyl acetate > ethanol, in the full temperature range covered by the experiments (283−308 K). An analysis of the structures of the different solutions on the basis of molecular dynamics simulation results indicated that this trend seems to be determined by a balance between the solute tendency toward aggregation and the ability of the solvent to efficiently solvate it, by integrating the cluster structures, regardless of their size, and effectively establishing solvent−solute interactions.

Nickel nanoparticles are an active research area due to their multiple applications as catalysts in different processes. A variety of preparation techniques have been reported for the synthesis of these nanoparticles, including solvothermal, microwave-assisted, and emulsion techniques. The well-studied solvothermal oleylamine synthesis route comes with the drawback of needing standard air-free techniques and often space-consuming glassware. Here, we present a facile and straightforward synthesis method for size-controlled highly monodisperse nickel nanoparticles avoiding the use of, e.g., Schlenk techniques and space-consuming labware. The nanoparticles produced by this novel synthetic route were investigated using small-angle X-ray scattering, transmission electron microscopy, X-ray diffraction, and X-ray spectroscopy. The nanoparticles were in a size range of 4–16 nm, show high sphericity, no oxidation, and no agglomeration after synthesis.

The formation of ternary inclusion complexes of γ-cyclodextrin (γ-CD) with two different pairs of interacting monomers (4-vinylpyridine (4VP) with styrenesulfonate (SS), which can interact through attractive Coulombic interactions, and styrene (S) with 2,3,4,5,6-pentafluorostyrene (PFS), which interact through quadrupole interactions) is studied. Ternary inclusion complexes are formed for both monomer pairs, but 4VP and SS are included in the complexes in approximately the same ratio as is present in solution, whereas S and PFS are preferentially included as a pair. The influence of the ternary inclusion complexation on the copolymerization was studied. For the copolymerization of 4VP with SS no significant influence was found, whereas an enhanced tendency toward alternating copolymerization was found for the copolymerization of S and PFS in the presence of γ-CD, which is ascribed to the preferential heteroinclusion of the monomers in the γ-CD cavity.