Echovirus 13 Aseptic Meningitis, Brazil

Kmetzsch, Claudete Iris; Balkie, Estela M.R.; Monteiro, Anita; Costa, Eliane Veiga da; Santos, Gina Peres Lima dos; Silva, Edson E. da

doi:10.3201/eid1708.051317

Cited by 9 publications

(11 citation statements)

References 7 publications

(5 reference statements)

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“…several sporadic cases and at least seven aseptic meningitis outbreaks with enteroviral etiology were identified. Six of them were caused by E30 [Dos Kmetzsch et al, 2006].…”

Section: Discussionmentioning

confidence: 99%

“…In addition to causing outbreaks, aseptic meningitis can present as sporadic cases (SC), keeping active the circulation of the viral serotypes involved in these cases [Thoelen et al, 2003;Kmetzsch et al, 2006;Grenón et al, 2008;Mirand et al, 2008;Tavakoli et al, 2008;Papa et al, 2009]. Detection and typing of the enterovirus involved in clinical disorders is valuable in relating the serotypes to these diseases and contributes to their surveillance [Tavakoli et al, 2008].…”

Section: Introductionmentioning

confidence: 99%

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Genetic diversity of echovirus 30 involved in aseptic meningitis cases in Brazil (1998–2008)

Santos

Costa

Tavares

et al. 2011

Journal of Medical Virology

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Aseptic meningitis is one of the most common neurological disorders caused by enteroviruses. Among them, Echovirus 30 (E30) is described as the main etiological agent of many outbreaks and sporadic cases. This study investigated the genomic variability of E30 isolated from the cerebrospinal fluid (CSF) of aseptic meningitis cases that occurred from 1998 to 2008 in Brazil. Over a 10-year period (1998-2008), 302 non-polio enteroviruses were isolated, of which 177 were identified as E30 (58.6%). Phylogenetic analysis of the complete VP1 gene (876 nt) of 48 E30 isolates was performed and compared with additional Brazilian and foreign strains. E30 VP1 sequences segregated into three distinct major groups and seven subgroups, which were linked to the isolation year. In general, sequence divergence among E30 strains ranged from 0.2% to 13.8%. A common direct ancestor for this set of E30 strains was not defined. Brazilian isolates from Group I were related genetically to a 1997 USA isolate and both may have a common origin. Group III representatives showed close relationship to the 2007 Argentinean isolates. The present results complement existing data on the molecular characterization and genetic variability of E30 and may contribute to the understanding of the epidemiology of aseptic meningitis in the region.

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“…several sporadic cases and at least seven aseptic meningitis outbreaks with enteroviral etiology were identified. Six of them were caused by E30 [Dos Kmetzsch et al, 2006].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genetic diversity of echovirus 30 involved in aseptic meningitis cases in Brazil (1998–2008)

Santos

Costa

Tavares

et al. 2011

Journal of Medical Virology

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“…[1][2][3][4][5] No Brasil, os enterovírus também são os principais responsáveis pela meningite viral. 6 O comportamento epidêmico não é só observado no Recife, senão também em outras cidades brasileiras 7,[16][17][18][19][20] e países do mundo, 3,5,[8][9][10][11][12] incluindo os mais desenvolvidos. As duas epidemias detectadas foram diferentes, tanto no que se refere à magnitude quanto no delineamento das curvas.…”

Section: Mês/anounclassified

“…Quanto à sintomatologia, a maior frequência de casos com cefaleia, febre e vômitos também foi descrita em outros estudos, na maioria dos quais a febre foi o principal sinal da doença; 7,16,18,19 exceto em Salvador, 20 cuja manifestação clínica mais frequente foi a cefaleia, padrão semelhante ao encontrado nas duas epidemias do Recife.…”

Section: Mês/anounclassified

Descrição do processo endêmico-epidêmico da meningite viral no Recife entre 1998 e 2008

Lima¹,

Filho²,

Ferreira³

et al. 2011

Epidemiol. Serv. Saúde

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“…Different serotypes of enteroviruses, such as echovirus 4 (E4), E6, E13, E30 and coxsackievirus B5, are involved in outbreaks and sporadic cases of aseptic meningitis around the world (Choi et al 2010;Dos Santos et al 2006;Grenón et al 2008;Hayashi et al 2009;Juliá et al 2009;Kmetzsch et al 2006;Mirand et al 2008;Papa et al 2009;Tavakoli et al 2008;Thoelen et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Direct Detection of Enterovirus Genome in Cell-Culture Negative Cerebrospinal Fluid From Aseptic Meningitis Cases in Brazil

Santos¹,

Burlandy²,

Costa³

et al. 2012

VR&R

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Enteroviruses are the main etiologic agents involved in outbreaks and sporadic cases of aseptic meningitis. Viral isolation in permissive cells is a traditional method for diagnosis, but it is time consuming and may be unsuccessful due to low viral titers and because some enteroviruses do not replicate in routine cell cultures. Therefore, molecular techniques are increasingly being used for detection of these agents. In the present work, 267 cerebrospinal fluid (CSF) samples from aseptic meningitis and meningoencephalitis cases, received between 2008 and 2009, were tested by RT-PCR. These clinical samples were previously negative for virus isolation in cell culture. Enterovirus genome was detected in 59 CSF samples (22.1%) and identification was confirmed by partial nucleotide sequencing. Some demographics of the patients included in the study were analyzed. Direct detection of enterovirus genome from CSF is appropriate to increase sensitivity in aseptic meningitis and meningoencephalitis cases.

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Echovirus 13 Aseptic Meningitis, Brazil

Cited by 9 publications

References 7 publications

Genetic diversity of echovirus 30 involved in aseptic meningitis cases in Brazil (1998–2008)

Genetic diversity of echovirus 30 involved in aseptic meningitis cases in Brazil (1998–2008)

Descrição do processo endêmico-epidêmico da meningite viral no Recife entre 1998 e 2008

Direct Detection of Enterovirus Genome in Cell-Culture Negative Cerebrospinal Fluid From Aseptic Meningitis Cases in Brazil

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