Echogenic exosomes as ultrasound contrast agents

Osborn, Jenna; Pullan, Jessica E.; Froberg, James; Shreffler, Jacob; Gange, Kara N.; Molden, Todd; Choi, Yongki; Brooks, Amanda E.; Mallik, Sanku; Sarkar, Kausik

doi:10.1039/d0na00339e

Cited by 13 publications

(9 citation statements)

References 63 publications

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“…They measured the linear and non-linear scatter of the response signals obtained from echogenic exosomes and applied to image them in an in vivo setup. The results showed significant increase in brightness with echogenic exosomes while, the preparation method of the echogenic exosomes, involved series of freeze-thawing and freeze drying cycle in the presence of mannitol [ 414 ]. Unlike, the echogenic liposomes encapsulated with bigger sized microbubbles, the echogenic exosomes were preformed vesicles, and are in submicron size [ 415 ].…”

Section: Ultrasound Enhances the Theranostic Property Of Exosomesmentioning

confidence: 99%

Exosomes and ultrasound: The future of theranostic applications

Sridharan

Lim

2023

Materials Today Bio

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Section: Ultrasound Enhances the Theranostic Property Of Exosomesmentioning

confidence: 99%

Exosomes and ultrasound: The future of theranostic applications

Sridharan

Lim

2023

Materials Today Bio

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“…Osborn and colleagues demonstrated the ability of the reconstituted exosomes to generate both linear and nonlinear response to ultrasound excitation and act as ultrasound contrast agents [ 79 ]. The authors made bovine milk-derived exosomes echogenic by freeze-drying them in the presence of mannitol and assessed the echogenicity of the prepared exosomes.…”

Section: Different Radiological Modalities and Nuclear Imaging Whimentioning

confidence: 99%

“…The authors made bovine milk-derived exosomes echogenic by freeze-drying them in the presence of mannitol and assessed the echogenicity of the prepared exosomes. Researchers registered more than a three-fold increase in the brightness of the kidney when the studied exosomes were injected into the vein [ 79 ].…”

Section: Different Radiological Modalities and Nuclear Imaging Whimentioning

confidence: 99%

Current Perspectives on Clinical Use of Exosomes as a Personalized Contrast Media and Theranostics

Lorenc

Chrzanowski

Olejarz

2020

Cancers

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An appropriate combination of biomarkers and imaging technologies will become standard practice in the future. Because the incidence of and mortality from cancers is rising, the further study of new approaches for the early detection and precise characterization of tumors is essential. Extracellular vesicles (EVs), including exosomes, prove to have great potential when it comes to diagnosis and targeted therapy. Due to their natural ability to pass through biological barriers, depending on their origin, EVs can accumulate at defined sites, including tumors, preferentially. This manuscript discusses the difficulties and simplicities of processing cell-derived materials, packaging diverse groups of agents in EVs, and activating the biological complex. Developing exosome-based diagnostic techniques to detect disease precisely and early as well as treat disease marks a new era of personalized radiology and nuclear medicine. As circulating drug delivery vehicles for novel therapeutic modalities, EVs offer a new platform for cancer theranostic.

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“…Their lack of toxicity and minimal immunogenic response give them an advantage over conventional liposomes. These echogenic exosomes showed significant linear and nonlinear scattered responses and can be used as effective ultrasound-responsive drug delivery systems [ 299 ].…”

Section: Reviewmentioning

confidence: 99%

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

Fateh¹,

Moradi²,

Kohan³

et al. 2021

Beilstein J. Nanotechnol.

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The field of theranostics has been rapidly growing in recent years and nanotechnology has played a major role in this growth. Nanomaterials can be constructed to respond to a variety of different stimuli which can be internal (enzyme activity, redox potential, pH changes, temperature changes) or external (light, heat, magnetic fields, ultrasound). Theranostic nanomaterials can respond by producing an imaging signal and/or a therapeutic effect, which frequently involves cell death. Since ultrasound (US) is already well established as a clinical imaging modality, it is attractive to combine it with rationally designed nanoparticles for theranostics. The mechanisms of US interactions include cavitation microbubbles (MBs), acoustic droplet vaporization, acoustic radiation force, localized thermal effects, reactive oxygen species generation, sonoluminescence, and sonoporation. These effects can result in the release of encapsulated drugs or genes at the site of interest as well as cell death and considerable image enhancement. The present review discusses US-responsive theranostic nanomaterials under the following categories: MBs, micelles, liposomes (conventional and echogenic), niosomes, nanoemulsions, polymeric nanoparticles, chitosan nanocapsules, dendrimers, hydrogels, nanogels, gold nanoparticles, titania nanostructures, carbon nanostructures, mesoporous silica nanoparticles, fuel-free nano/micromotors.

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Echogenic exosomes as ultrasound contrast agents

Abstract:
Exosomes, naturally secreted extracellular bilayer vesicles (diameter 40–130 nm), have been rendered echogenic (responsive to ultrasound) allowing their potential use as a dual agent for drug delivery and ultrasound imaging.

Cited by 13 publications

References 63 publications

Exosomes and ultrasound: The future of theranostic applications

Exosomes and ultrasound: The future of theranostic applications

Current Perspectives on Clinical Use of Exosomes as a Personalized Contrast Media and Theranostics

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

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Echogenic exosomes as ultrasound contrast agents

Abstract: Exosomes, naturally secreted extracellular bilayer vesicles (diameter 40–130 nm), have been rendered echogenic (responsive to ultrasound) allowing their potential use as a dual agent for drug delivery and ultrasound imaging.

Cited by 13 publications

References 63 publications

Exosomes and ultrasound: The future of theranostic applications

Exosomes and ultrasound: The future of theranostic applications

Current Perspectives on Clinical Use of Exosomes as a Personalized Contrast Media and Theranostics

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

Contact Info

Product

Resources

About

Abstract:
Exosomes, naturally secreted extracellular bilayer vesicles (diameter 40–130 nm), have been rendered echogenic (responsive to ultrasound) allowing their potential use as a dual agent for drug delivery and ultrasound imaging.