Exosomes and ultrasound: The future of theranostic applications

Sridharan, Badrinathan; Lim, Hae Gyun

doi:10.1016/j.mtbio.2023.100556

Cited by 12 publications

(5 citation statements)

References 430 publications

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“…At 4 weeks after operation, the expression of VEGF in SrTCP scaffolds with different Sr doping amounts was higher than that in Β-TCP, which indicated that the Sr ions released from SrTCP scaffolds could promote the expression of VEGF in M1 macrophages. PDGF-bb can promote the development and maturation of blood vessels, which is necessary for angiogenesis [ 32 ]. From the PCR results and the immunohistochemical staining results of PDGF-bb, the expression of PDGF-bb in Sr5TCP, Sr10 TCP, and Sr20 TCP were higher than those of the β-TCP group at 1 and 4 weeks after operation.…”

Section: Resultsmentioning

confidence: 99%

3D printed strontium-doped calcium phosphate ceramic scaffold enhances early angiogenesis and promotes bone repair through the regulation of macrophage polarization

Miao,

Yang,

Diao

et al. 2023

Materials Today Bio

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Section: Resultsmentioning

confidence: 99%

3D printed strontium-doped calcium phosphate ceramic scaffold enhances early angiogenesis and promotes bone repair through the regulation of macrophage polarization

Miao,

Yang,

Diao

et al. 2023

Materials Today Bio

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“…Electroporation involves changes in the membrane structure excited by physical means. [196] Chen et al mixed rifampicin with exosomes derived from BMSC and treated them with ultrasound. The results showed that this strategy successfully loaded rifampicin into exosomes, activating dynein 1 and inducing mitochondrial apoptosis, resulting in a good anti-osteosarcoma effect (Figure 9D).…”

Section: Exogenous Modificationmentioning

confidence: 99%

“…Electroporation involves changes in the membrane structure excited by physical means. [ 196 ] Chen et al. mixed rifampicin with exosomes derived from BMSC and treated them with ultrasound.…”

Section: Micro‐modification Of Evs: Engineered Evs To Promote the Rep...mentioning

confidence: 99%

Extracellular Vesicles in the Repair of Bone and Cartilage Injury: From Macro‐Delivery to Micro‐Modification

Xu,

Li,

et al. 2024

Advanced Therapeutics

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Extracellular vesicles (EVs) are intermediaries in intercellular signal transmission and material exchange and have attracted significant attention from researchers in bone and cartilage repair. These nanoscale vesicles hold immense potential in facilitating bone and cartilage repair and regeneration by regulating the microenvironment at an injury site. However, their in vivo utilization is limited by their self‐clearance and random distribution. Therefore, various delivery platforms have been developed to improve EV targeting and retention rates in target organs while achieving a controlled release of EVs. Additionally, engineering modification of EVs has been proposed to effectively enhance EVs' intrinsic targeting and drug‐loading abilities and further improve their therapeutic effects on bone and cartilage injuries. This review aims to introduce the biogenesis of EVs and their regulatory mechanisms in the microenvironment of bone and cartilage injuries and comprehensively discuss the application of EV‐delivery platforms of different materials and various EV engineering modification methods in treating bone and cartilage injuries. The review's findings could help advance EV research and develop new strategies for improving the therapy of bone and cartilage injuries.This article is protected by copyright. All rights reserved

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“…Environmental parameters play a pivotal role in modulating physiological conditions that not only facilitate the production of EVs but can also enhance their therapeutic properties [106,112,113]. The major category is physical cues, which can be further delineated into mechanical, acoustic, and electrical stimuli.…”

Section: Physicochemical Stimulimentioning

confidence: 99%

Engineering extracellular vesicles for ROS scavenging and tissue regeneration

Abdal Dayem,

Yan,

et al. 2024

Nano Convergence

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Stem cell therapy holds promise for tissue regeneration, yet significant challenges persist. Emerging as a safer and potentially more effective alternative, extracellular vesicles (EVs) derived from stem cells exhibit remarkable abilities to activate critical signaling cascades, thereby facilitating tissue repair. EVs, nano-scale membrane vesicles, mediate intercellular communication by encapsulating a diverse cargo of proteins, lipids, and nucleic acids. Their therapeutic potential lies in delivering cargos, activating signaling pathways, and efficiently mitigating oxidative stress—an essential aspect of overcoming limitations in stem cell-based tissue repair. This review focuses on engineering and applying EVs in tissue regeneration, emphasizing their role in regulating reactive oxygen species (ROS) pathways. Additionally, we explore strategies to enhance EV therapeutic activity, including functionalization and incorporation of antioxidant defense proteins. Understanding these molecular mechanisms is crucial for optimizing EV-based regenerative therapies. Insights into EV and ROS signaling modulation pave the way for targeted and efficient regenerative therapies harnessing the potential of EVs.

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Exosomes and ultrasound: The future of theranostic applications

Cited by 12 publications

References 430 publications

3D printed strontium-doped calcium phosphate ceramic scaffold enhances early angiogenesis and promotes bone repair through the regulation of macrophage polarization

3D printed strontium-doped calcium phosphate ceramic scaffold enhances early angiogenesis and promotes bone repair through the regulation of macrophage polarization

Extracellular Vesicles in the Repair of Bone and Cartilage Injury: From Macro‐Delivery to Micro‐Modification

Engineering extracellular vesicles for ROS scavenging and tissue regeneration

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