Echocardiographic and biochemical predictors of ventricular arrhythmias in young patients with mitral valve prolapse

Малев, Э. Г.; Реева, С. В.; Timofeev, E.; Pshepiy, Asiyet; Korshunova, Alexandra; Zemtsovsky, E.

doi:10.1093/eurheartj/eht310.p4747

Cited by 2 publications

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“…Как уже отмечалось, с дезрегуляцией TGF-β принято ассоциировать такие важные характеристики первичного ПМК, как наличие и выраженность миксоматозной дегенерации створок, степень тяжести митральной регургитации, а также развитие желудочковых нарушений сердечного ритма [26]. Известно также, что у пациентов с СМ и ПМК на фоне высокого уровня TGF-β нередко обнаруживается утолщение миокарда со снижением локальной систолической сократимости левого желудочка.…”

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The activity of transforming growth factor-β in young age with marfanoid habitus

et al. 2019

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According to contemporary views, hereditary connective tissue disorders divided classified Marfan syndrome, Loeys-Dietz’s, Ehlers-Danlos syndrome, the primary mitral valve prolapse. It is known that the fibrillinopaty, which include the Marfan syndrome and Loeys-Dietz’s is characterized by activation of TGF-β signaling pathway. With high le vels of TGF-β attributed most of these clinical manifestations these diseases – aneurysm of the aorta, arahnodaktylya, duralectasy. Assessment of the activity of TGF-β in persons with marfanoid habitus has not previously been studied. Materials and methods. As part of this work, surveyed 70 people: 61 patients young age (median age of 20.1 ± 2.1 years), among which 36 boys and 25 girls and 9 men with verified diagnosis Marfan syndrome (median age 27.9 ± 9.3 years). All survey performed Echocardiography with a targeted search of small anomalies of heart. Results. Correlation analysis showed a direct and reliable connection between arahnodaktylya and concentration of TGF-β1 in serum (r = 0.4, p = 0.05). For young people with signs of marfanoid habitus are characterized by reliably a higher concentration in the serum of both isoforms of TGF-β. Excess of threshold levels of TGF-β1 revealed at 20% of the core group and not found at all in the control (p < 0.05). Among persons with exceedances of threshold values for at least one faction of the TGF-β patients with signs of marfanoid habitus met almost three times more often than in the group with normal values of TGF-β (p = 0.01, χ2 = 5.58). In the group of persons with marfanoid habitus and increases TGF-β are detected more frequently such as atrial septal aneurysm, false chord left ventricle papillary muscles, incremental, deflection of shutters of the mitral valve in 1-2 mm, asymmetry tricuspid aortic valve.

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The activity of transforming growth factor-β in young age with marfanoid habitus

et al. 2019

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Relationship of cardiac arrhythmias to myocardial remodeling and expression of adhesion molecules in patients with mitral valve prolapse

Yagoda¹,

Гладких²,

Gladkikh³

2014

Ann Aritmol

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помощью эхокардиографии (ЭхоКГ) в М-, В-и допплеровском режимах («Vivid-7», Израиль). Плазменные концентрации L-, E-, Р-селектинов, молекул адгезии 1-го типа -межклеточной (ICAM-1), тромбоцитарно-эндотелиальной (PECAM-1) и сосудистой (VCAM-1) были определены методом иммуноферментного анализа («Bender MedSystems GmbH», Австрия (относительный риск (ОР) 3,9, 95% доверительный интервал (ДИ) 1,9-7,7), индексе конечного систолического объема более 24,3 мл/м 2 (ОР 4,2, 95% ДИ 2,1-8,2), ударном индексе более 45,4 мл/м 2 (ОР 3,3, 95% ДИ 1,7-6,7), концентрации VCAM-1 более 1588,8 нг/мл (ОР 2,3, 95% ДИ 1,1-4,9

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Echocardiographic and biochemical predictors of ventricular arrhythmias in young patients with mitral valve prolapse

Cited by 2 publications

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The activity of transforming growth factor-β in young age with marfanoid habitus

The activity of transforming growth factor-β in young age with marfanoid habitus

Relationship of cardiac arrhythmias to myocardial remodeling and expression of adhesion molecules in patients with mitral valve prolapse

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