Echinacea purpurea Mediated Hematite Nanoparticles (α-HNPs) Biofabrication, Characterization, Physicochemical Properties, and its In-vitro Biocompatibility Evaluation

Al-Hakkani, Mostafa F.; Gouda, Gamal A.; Hassan, Sedky H.A.; Nagiub, Adham M.

doi:10.1016/j.surfin.2021.101113

Cited by 25 publications

(39 citation statements)

References 84 publications

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“…Various AZM characteristic bands could be identified in the spectra acquired straight from the solid standard, as shown in Figure 1A. The main bands identified were (i) bands associated with the axial stretching and bending of C-H of the methyl groups, which were found in the ranges of 2966-2985 cm −1 and 1367-1374 cm −1 , respectively [57,58]; (ii) the sharp and powerful band at 1710-1722 cm −1 , which could be attributed to the axial stretching of the lactone's C=O group; and (iii) other notable bands in the spectra, including those found in the 1130-1225 cm −1 region, which emerged due to absorption related to C-O axial stretching [59].…”

Section: Ft-ir Analysismentioning

confidence: 99%

Tailoring of Novel Azithromycin-Loaded Zinc Oxide Nanoparticles for Wound Healing

et al. 2022

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Skin is the largest mechanical barrier against invading pathogens. Following skin injury, the healing process immediately starts to regenerate the damaged tissues and to avoid complications that usually include colonization by pathogenic bacteria, leading to fever and sepsis, which further impairs and complicates the healing process. So, there is an urgent need to develop a novel pharmaceutical material that promotes the healing of infected wounds. The present work aimed to prepare and evaluate the efficacy of novel azithromycin-loaded zinc oxide nanoparticles (AZM-ZnONPs) in the treatment of infected wounds. The Box–Behnken design and response surface methodology were used to evaluate loading efficiency and release characteristics of the prepared NPs. The minimum inhibitory concentration (MIC) of the formulations was determined against Staphylococcus aureus and Escherichia coli. Moreover, the anti-bacterial and wound-healing activities of the AZM-loaded ZnONPs impregnated into hydroxyl propyl methylcellulose (HPMC) gel were evaluated in an excisional wound model in rats. The prepared ZnONPs were loaded with AZM by adsorption. The prepared ZnONPs were fully characterized by XRD, EDAX, SEM, TEM, and FT-IR analysis. Particle size distribution for the prepared ZnO and AZM-ZnONPs were determined and found to be 34 and 39 nm, respectively. The mechanism by which AZM adsorbed on the surface of ZnONPs was the best fit by the Freundlich model with a maximum load capacity of 160.4 mg/g. Anti-microbial studies showed that AZM-ZnONPs were more effective than other controls. Using an experimental infection model in rats, AZM-ZnONPs impregnated into HPMC gel enhanced bacterial clearance and epidermal regeneration, and stimulated tissue formation. In conclusion, AZM -loaded ZnONPs are a promising platform for effective and rapid healing of infected wounds.

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Section: Ft-ir Analysismentioning

confidence: 99%

Tailoring of Novel Azithromycin-Loaded Zinc Oxide Nanoparticles for Wound Healing

et al. 2022

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“…[11] Green nano coordination complexes synthesis using plant extract is a more effective, non-toxic, hazard-free, low-cost, and environmentally friendly method. [11][12][13] Cu nano coordination complexes are not found in the previous literature.…”

Section: Introductionmentioning

confidence: 77%

“…The particle size of the nano complexes was calculated from the Scherrer equation. [12,25,26] The average particle size of crystalline complexes ranged between 30.53 and 41.48 nm, which was located in nano-scale range.…”

Section: Powder Xrdmentioning

confidence: 99%

Novel Nano Copper Complexes of a New Schiff Base: Green Synthesis, a New Series of Solid Cr(II), Co(II), Cu(II), Pd(II) and Cd(II) Chelates, Characterization, DFT, DNA, Antitumor and Molecular Docking Studies

Hosny

Gouda

Abu‐El‐Wafa

2022

Applied Organom Chemis

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A new series of solid Cr(II), Co(II), Cu(II), Pd(II), and Cd(II) chelates of the 1-((E)-(2-mercaptophenylimino)methyl)naphthalen-2-ol (H 2 L) Schiff base ligand were synthеsized and chаracterized by diffеrent аnalytical and spectroscopic tеchniques. The results revealed the geometry around central metal ion to be tetrahedral for Cr 2 L 2 , Co 2 L 2 , Cu 2 L 2 , and Cd 2 L 2 complexes and square planar geometry around Pd 2 L 2 complex. 3D modeling of the ligand and its metal complexes was obtained using DFT/B3LYP method with LANL2DZ basis set. Also quantum-mechanical properties like molecular orbitals and molecular energies were calculated. The Cu nano complexes were prepared in different media Spinacia oleracea (SO), Corchorus olitorius (CO), Coriandrum sativum (CS), Eruca sativa (ES), and Anethum graveolens (AG) extract in EtOH. The particle size of the nano coordination Cu complexes depends on the high concentration of reducing agent present in the green leaf extract. The nature of the newly nano sizеd Cu complexes prepared in different media as crystalline or amorphous and particles size was determined by X-ray diffraction (XRD); scanning electron microscope (SEM). The Cu nano complexes are characterized by spectroscopic and thermal analysis techniques before heating and after heating upon 200 C. The Cu nano complexes were showed an antitumor activity towards hepatocellular carcinoma cell line (HepG-2). The antitumor data revealed that the Cu nano complex prepared in CS/EtOH (IC 50 $ 4.9 μg ml À1 ) has antitumor activity nearly to the activity of cis-platin (IC50 $ 1.143 μg ml À1 ). The DNA cleavage study showed that the ability for the screened Cu nano complex prepared in CS/EtOH to cleavage DNA. Therefore, it may be used as antitumor drugs in vivo to prevent the DNA replication in the tumor cells and to suppress the cancer for further increasing. Docking studies of the ligand and its Cu(II) complex showed good binding energy score ranging from (À4.73 to À5.98 kcal mol À1 ).

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“…The as-biofabricated α-HNPs were prepared and characterized using various instrumental techniques as in our previously reported green biosynthesis approaches 7 , 29 .…”

Section: Methodsmentioning

confidence: 99%

“…The zero-point charge is known as the pH solution where a neutrally charged nature of the surface of α-HNPs. The used pH drift method could be derived as previously reported by Al-Hakkani et al 29 . The zero-point charge could be estimated using the intersection of the curve between the initial and final pH solution of the standard and test solution that contains Azr @ α-HNPs .…”

Section: Methodsmentioning

confidence: 99%

Environmentally azithromycin pharmaceutical wastewater management and synergetic biocompatible approaches of loaded azithromycin@hematite nanoparticles

Al-Hakkani

Gouda

Hassan

et al. 2022

Sci Rep

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Pharmaceutical wastewater contamination via azithromycin antibiotic and the continuous emergence of some strains of bacteria, cancer, and the Covid-19 virus. Azithromycin wastewater treatment using the biosynthesized Hematite nanoparticles (α-HNPs) and the biocompatible activities of the resulted nanosystem were reported. Biofabrication of α-HNPs using Echinaceapurpurea liquid extract as a previously reported approach was implemented. An evaluation of the adsorption technique via the biofabricated α-HNPs for the removal of the Azr drug contaminant from the pharmaceutical wastewater was conducted. Adsorption isotherm, kinetics, and thermodynamic parameters of the Azr on the α-HNPs surface have been investigated as a batch mode of equilibrium experiments. Antibacterial, anticancer, and antiviral activities were conducted as Azr@α-HNPs. The optimum conditions for the adsorption study were conducted as solution pH = 10, 150 mg dose of α-HNPs, and Azr concentration 400 mg/L at 293 K. The most fitted isothermal model was described according to the Langmuir model at adsorption capacity 114.05 mg/g in a pseudo-second-order kinetic mechanistic at R2 0.9999. Thermodynamic study manifested that the adsorption behavior is a spontaneous endothermic chemisorption process. Subsequently, studying the biocompatible applications of the Azr@α-HNPs. Azr@α-HNPs antibacterial activity revealed a synergistic effect in the case of Gram-positive more than Gram-negative bacteria. IC50 of Azr@α-HNPs cytotoxicity against MCF7, HepG2, and HCT116 cell lines was investigated and it was found to be 78.1, 81.7, and 93.4 µg/mL respectively. As the first investigation of the antiviral use of Azr@α-HNPs against SARS-CoV-2, it was achieved a safety therapeutic index equal to 25.4 revealing a promising antiviral activity. An admirable impact of the use of the biosynthesized α-HNPs and its removal nanosystem product Azr@α-HNPs was manifested and it may be used soon as a platform of the drug delivery nanosystem for the biomedical applications.

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Echinacea purpurea Mediated Hematite Nanoparticles (α-HNPs) Biofabrication, Characterization, Physicochemical Properties, and its In-vitro Biocompatibility Evaluation

Cited by 25 publications

References 84 publications

Tailoring of Novel Azithromycin-Loaded Zinc Oxide Nanoparticles for Wound Healing

Tailoring of Novel Azithromycin-Loaded Zinc Oxide Nanoparticles for Wound Healing

Novel Nano Copper Complexes of a New Schiff Base: Green Synthesis, a New Series of Solid Cr(II), Co(II), Cu(II), Pd(II) and Cd(II) Chelates, Characterization, DFT, DNA, Antitumor and Molecular Docking Studies

Environmentally azithromycin pharmaceutical wastewater management and synergetic biocompatible approaches of loaded azithromycin@hematite nanoparticles

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