2020
DOI: 10.1113/jp278833
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Early weaning induces short‐ and long‐term effects on pancreatic islets in Wistar rats of both sexes

Abstract: Key points The World Health Organization recommends exclusive breastfeeding until 6 months of age as an important strategy to reduce child morbidity and mortality. Studies have associated early weaning with the development of obesity and type 2 diabetes in adulthood. In our model, we demonstrated that early weaning leads to increased insulin secretion in adolescent males and reduced insulin secretion in adult offspring. Early weaned males exhibit insulin resistance in skeletal muscle. Early weaning did not ch… Show more

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Cited by 18 publications
(27 citation statements)
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References 53 publications
(89 reference statements)
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“…They also demonstrate marked sex differences with respect to insulin secretion in early life and adulthood, as well as with regard to the susceptibility to weaning-induced pancreatic islet cell dysfunction, indicating some of the potential molecular mechanisms involved. The studies by Pietrobon et al (2020) further support the importance of endogenous sex hormones in the regulation of glucose metabolism and insulin function. Given that all three oestrogen receptors (ERα, ERβ and GPER) modulate insulin secretion and sensitivity (Alonso-Magdalena et al 2008;Ropero et al 2012;Sharma & Prossnitz, 2011), future studies should also investigate the effect of ovariectomy or oestrogen supplementation and include the use of animal models in which these receptors have been deleted from the genome (Meyer et al 2011) to further decipher the underlying mechanisms.…”
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confidence: 64%
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“…They also demonstrate marked sex differences with respect to insulin secretion in early life and adulthood, as well as with regard to the susceptibility to weaning-induced pancreatic islet cell dysfunction, indicating some of the potential molecular mechanisms involved. The studies by Pietrobon et al (2020) further support the importance of endogenous sex hormones in the regulation of glucose metabolism and insulin function. Given that all three oestrogen receptors (ERα, ERβ and GPER) modulate insulin secretion and sensitivity (Alonso-Magdalena et al 2008;Ropero et al 2012;Sharma & Prossnitz, 2011), future studies should also investigate the effect of ovariectomy or oestrogen supplementation and include the use of animal models in which these receptors have been deleted from the genome (Meyer et al 2011) to further decipher the underlying mechanisms.…”
mentioning
confidence: 64%
“…When the investigators repeated the studies in animals at 6 months of age, the sex differences in insulin secretion in normally weaned animals not only disappeared, but were actually reversed, with much greater insulin secretion in males. However, compared to both adult controls and early weaned adolescent animals, insulin secretion was greatly attenuated in both males and females (Pietrobon et al 2020). These novel and important findings indicate that significant early life sex differences exist with regard to pancreatic insulin secretion, and also that, in adulthood, previous early life stress caused by maternal separation is associated with long-term attenuation of insulin secretion in both males and females.…”
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confidence: 70%
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