Early life stress determines insulin signalling in adulthood

Barton, Matthias; Prossnitz, Eric R.

doi:10.1113/jp279300

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Decades of research have documented the roles of the classical estrogen receptors (ERα and ERβ) in the metabolism and homeostasis of glucose and lipids but the importance of GPER in these processes is coming to light [15]. Recent evidence suggests that many aspects of glucose-mediated insulin synthesis and release from β-cells as well as insulin signaling in peripheral tissues involve rapid non-genomic GPER-mediated estrogen signaling [15,16]. In addition, GPER expression in the pancreatic islets is associated with the enhancement of overall survival and prevention of apoptosis of β-cells [17,18].…”

Section: Gper System In Dmmentioning

confidence: 99%

Comparative G-Protein-Coupled Estrogen Receptor (GPER) Systems in Diabetic and Cancer Conditions: A Review

et al. 2022

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For many patients, diabetes Mellitus and Malignancy are frequently encountered comorbidities. Diabetes affects approximately 10.5% of the global population, while malignancy accounts for 29.4 million cases each year. These troubling statistics indicate that current treatment approaches for these diseases are insufficient. Alternative therapeutic strategies that consider unique signaling pathways in diabetic and malignancy patients could provide improved therapeutic outcomes. The G-protein-coupled estrogen receptor (GPER) is receiving attention for its role in disease pathogenesis and treatment outcomes. This review aims to critically examine GPER’ s comparative role in diabetes mellitus and malignancy, identify research gaps that need to be filled, and highlight GPER’s potential as a therapeutic target for diabetes and malignancy management. There is a scarcity of data on GPER expression patterns in diabetic models; however, for diabetes mellitus, altered expression of transport and signaling proteins has been linked to GPER signaling. In contrast, GPER expression in various malignancy types appears to be complex and debatable at the moment. Current data show inconclusive patterns of GPER expression in various malignancies, with some indicating upregulation and others demonstrating downregulation. Further research should be conducted to investigate GPER expression patterns and their relationship with signaling pathways in diabetes mellitus and various malignancies. We conclude that GPER has therapeutic potential for chronic diseases such as diabetes mellitus and malignancy.

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Section: Gper System In Dmmentioning

confidence: 99%

Comparative G-Protein-Coupled Estrogen Receptor (GPER) Systems in Diabetic and Cancer Conditions: A Review

et al. 2022

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“…Insulin and GLUT5 interfere with the absorption of monosaccharides, such as glucose, galactose and fructose. 2,3 The resulting decrease in cellular levels of AMP and ADP, and the low energy environment, stimulates AMP-activated protein kinase (AMPK) phosphorylation. Subsequently, the levels of triglycerides (TG), cholesterol and HDL-C are decreased in the serum, and the transportation of ester materials is disturbed in the intestine, liver and other tissues.…”

Section: Introductionmentioning

confidence: 99%

Pyrroloquinoline quinone regulates glycolipid metabolism in the jejunum via inhibiting AMPK phosphorylation of weaned pigs

Huang

Shi

et al. 2022

Food Funct.

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Maternal separation influences hepatic drug-metabolizing CYP450 gene expression without pathological changes in adult mice

Jarrar,

Ashour,

Madani

et al. 2024

Journal of Basic and Clinical Physiology and Pharmacology

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Objectives The principal motive of this study is to explore the influence maternal separation (MS) exhibits on the mRNA expression of major drug metabolizing-cyp450s in parallel with the assessment of pathological changes that can be induced by MS in the livers of experimental mice. Methods Eighteen Balb/c mouse pups, comprising of both males and females, were separated from their mothers after birth. Following a six-week period during when the pups became adults, the mice were sacrificed and their livers were isolated for analysis of weight, pathohistological alterations, and the mRNA expression of drug metabolizing cyp450 genes: cyp1a1, cyp3a11, cyp2d9, and cyp2c29. Results The study demonstrated that MS markedly downregulated (p<0.05) the mRNA expression of all tested drug-metabolizing cyp450s in livers of female and male mice. Furthermore, the mRNA levels of major drug-metabolizing cyp450s were notably lower (p<0.05) in livers of female MS mice as compared with male MS mice. It was found that values of the total body weight and liver weight of MS mice did not vary significantly (p>0.05) from those of the control groups. Additionally, histological examination revealed that the hepatic tissue of MS mice was normal, similar to that of the control mice. Conclusions In summary, MS downregulates the gene expression of major hepatic drug-metabolizing cyp450s without inducing pathological alterations in the livers of mice. These findings provide an explanation for the heterogeneity in pharmacokinetics and drug response of patients with early life stress.

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Early life stress determines insulin signalling in adulthood

Cited by 3 publications

References 20 publications

Comparative G-Protein-Coupled Estrogen Receptor (GPER) Systems in Diabetic and Cancer Conditions: A Review

Comparative G-Protein-Coupled Estrogen Receptor (GPER) Systems in Diabetic and Cancer Conditions: A Review

Pyrroloquinoline quinone regulates glycolipid metabolism in the jejunum via inhibiting AMPK phosphorylation of weaned pigs

Maternal separation influences hepatic drug-metabolizing CYP450 gene expression without pathological changes in adult mice

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