Early - versus late-onset preeclampsia: differences in risk factors and birth outcomes

Маркін, Л. Б.; Medvyedyeva, O.

doi:10.25040/lkv2017.04.030

Cited by 4 publications

(5 citation statements)

References 7 publications

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“…This resonates with other studies that shows impaired fetal growth along with higher perinatal mortality and morbidity among women with EO-PE than among non-PE or LO-PE women [23,31]. Previous research similarly shows higher rates of premature births, NICU admission, severe neonatal morbidity and neonatal deaths among newborns of women with EO-PE [32][33][34].…”

Section: Plos Onesupporting

confidence: 86%

Clinical presentation and outcomes of pre-eclampsia and eclampsia at a national hospital, Kenya: A retrospective cohort study

et al. 2020

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BackgroundHypertensive disorders in pregnancy including pre-eclampsia are associated with maternal and newborn mortality and morbidity. Early detection is vital for effective treatment and management of pre-eclampsia. This study examines and compares the clinical presentation and outcomes between early-and late-onset pre-eclampsia over a two year period. MethodsA retrospective cohort study design which examines socio-demographic characteristics, treatment, outcomes, and fetal and maternal complications among women with early onset of pre-eclampsia (EO-PE) and late onset of pre-eclampsia (LO-PE). De-identified records of women who attended antenatal, intrapartum and postnatal care services and experienced pre-eclampsia at Kenyatta National teaching and referral hospital were reviewed. We used chi square, t-test, and calculated odds ratio to determine any significant differences between the EO-PE and LO-PE cohorts. ResultsOut of 620 pre-eclamptic and eclamptic patients' records analyzed; 44 percent (n = 273) exhibited EO-PE, while 56 percent had late onset. Women with EO-PE compared to LO-PE had greater odds of adverse maternal and perinatal outcomes including hemolysis elevated liver enzymes and low platelets (HELLP) syndrome (OR: 4.3;

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Section: Plos Onesupporting

confidence: 86%

Clinical presentation and outcomes of pre-eclampsia and eclampsia at a national hospital, Kenya: A retrospective cohort study

et al. 2020

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“…Because KNH is a national referral hospital for the most complex cases, there is a relatively high proportion NICU infants, regardless of PE/E onset. This study aligns with a number of others showing higher rates of neonatal deaths, premature births, NICU admission, and severe neonatal morbidity for infants born to mothers with EO-PE [43][44][45] .…”

Section: Nicu/nbu Admissionsupporting

confidence: 90%

Retrospective cohort study: Clinical presentation and outcomes of pre-eclampsia and eclampsia at Kenyatta National Hospital, Nairobi, Kenya

Ndwiga¹,

Osoti²,

Sripad³

et al. 2018

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Ending Eclampsia seeks to expand access to proven, under-utilized interventions and commodities for the prevention, early detection, and treatment of pre-eclampsia and eclampsia and strengthen global partnerships. The Population Council confronts critical health and development issues-from stopping the spread of HIV to improving reproductive health and ensuring that young people lead full and productive lives. Through biomedical, social science, and public health research in 50 countries, we work with our partners to deliver solutions that lead to more effective policies, programs, and technologies that improve lives around the world. Established in 1952 and headquartered in New York, the Council is a non-governmental, non-profit organization governed by an international board of trustees.

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“…This was in congruence with previous studies which similarly reported significantly higher rates of poor APGAR, low birth weight, and neonatal death rates in EO-PE compared to LO-PE [38,49]. Several similar studies also reported higher neonatal morbidity and mortality in EO-PE than LO-PE [4,39,[50][51][52]. Significant perinatal adverse outcomes associated with EO-PE can be due to the associated high frequency of SGA alone or another unsolved pathophysiologic mechanism that warrants further investigation [53].…”

Section: Plos Onesupporting

confidence: 88%

“…This was similar to another study conducted elsewhere [ 38 ]. In contrast, different studies have demonstrated that EO-PE and LO-PE could be different in respect to attributable risk factors [ 12 , 39 , 40 ]. Although different in terms of the prevalence of attributable risk factors between the two groups in the present work, the failure to attain statistical significance might be related to the nature of the data used in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies show that overall adverse perinatal outcomes are higher in women with EO-PE than in women with LO-PE [ 39 ]. Similarly, in the present study, the low fifth minute APGAR score (27.4% vs 6.6%), birth weight less than 2.5 kg (88.1% Vs 32.0%), and the rate of neonatal death (12.8% Vs 3.9%) were significantly higher in the EO-PE group than in the LO-PE group (p-value <0.05).…”

Section: Discussionmentioning

confidence: 99%

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Clinical presentation, maternal-fetal, and neonatal outcomes of early-onset versus late onset preeclampsia-eclampsia syndrome in a teaching hospital in a low-resource setting: A retrospective cohort study

et al. 2023

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Background Pre-eclampsia-eclampsia syndrome remains the leading cause of maternal and neonatal mortality worldwide. Both from pathophysiologic and clinical stand points, early and late onset preeclampsia are thought to be two different disease entities. However, the magnitude of preeclampsia-eclampsia and maternal-fetal and neonatal outcomes of early and late onset preeclampsia are not adequately investigated in resource-limited settings. This study sought to examine the clinical presentation and maternal-fetal and neonatal outcome of these two entities of the disease in Ayder comprehensive specialized hospital, an academic setting in Tigray, Ethiopia, from January 1, 2015—December 31, 2021. Methods A retrospective cohort design was employed. The patient charts were reviewed to see the baseline characteristics and their progress from the onset of the disease in the antepartum, intrapartum and postpartum periods. Women who developed pre-eclampsia before 34 weeks of gestation were defined as having early-onset pre-eclampsia, and those who developed at 34 weeks or later were identified as late-onset preeclampsia. We used chi-square, t-test and multivariable logistic regression analyses to determine differences between early- and late onset diseases in terms of clinical presentation, maternal-fetal, and neonatal outcomes. Results Among the 27,350 mothers who gave birth at the Ayder comprehensive specialized hospital, 1095 mothers had preeclampsia-eclampsia syndrome, with a prevalence of 4.0% (95% CI: 3.8, 4.2)]. Of the 934 mothers analyzed early and late onset diseases accounted for 253 (27.1%) and 681 (72.9%) respectively. Overall, death of 25 mothers was recorded. Women with early onset disease had significant unfavorable maternal outcomes including having preeclampsia with severity features (AOR = 2.92, 95% CI: 1.92, 4.45), liver dysfunction (AOR = 1.75, 95% CI: 1.04, 2.95), uncontrolled diastolic blood pressure (AOR = 1.71, 95% CI: 1.03, 2.84), and prolonged hospitalization (AOR = 4.70, 95% CI: 2.15, 10.28). Similarly, they also had increased unfavorable perinatal outcomes, including the APGAR score at the 5th minute (AOR = 13.79, 95% CI: 1.16, 163.78), low birth weight (AOR = 10.14, 95% CI 4.29, 23.91), and neonatal death (AOR = 6.82, 95% CI: 1.89, 24.58). Conclusion The present study highlights the clinical differences between early versus late onset preeclampsia. Women with early-onset disease are at increased levels of unfavorable maternal outcomes. Perinatal morbidity and mortality were also increased significantly in women with early onset disease. Therefore, gestational age at the onset of the disease should be taken as an important indicator of the severity of the disease with unfavorable maternal, fetal, and neonatal outcomes.

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Early - versus late-onset preeclampsia: differences in risk factors and birth outcomes

Cited by 4 publications

References 7 publications

Clinical presentation and outcomes of pre-eclampsia and eclampsia at a national hospital, Kenya: A retrospective cohort study

Clinical presentation and outcomes of pre-eclampsia and eclampsia at a national hospital, Kenya: A retrospective cohort study

Retrospective cohort study: Clinical presentation and outcomes of pre-eclampsia and eclampsia at Kenyatta National Hospital, Nairobi, Kenya

Clinical presentation, maternal-fetal, and neonatal outcomes of early-onset versus late onset preeclampsia-eclampsia syndrome in a teaching hospital in a low-resource setting: A retrospective cohort study

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