Early stage squamous cell carcinoma of the lower lip: predictive factors for recurrence

Özkul, Yılmaz; Songu, Murat; İmre, Abdülkadir; Tunç, Elif; Ozkul, Z; Arslanoğlu, Seçil; Pınar, Ercan; Önal, Kazım

doi:10.1017/s0022215116000311

Cited by 10 publications

(14 citation statements)

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“…1,3 OTSCC exhibits an aggressive biological behavior and has usually a poorer prognosis when compared to tumors at other sites. 4,5,6,7 Lower lip squamous cell carcinoma (LLSCC) is more common among male patients above the age of 50 years and solar radiation is the main etiological factor. 7 LLSCC is usually associated with a good prognosis and low mortality rate.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical expression of DNA repair proteins in oral tongue and lower lip squamous cell carcinoma

et al. 2020

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The DNA repair system involves genes and proteins that are essential for the maintenance of genome integrity and the consequent control of various cellular processes. Alterations in these genes and proteins play a role in tumor development and progression and might be associated with prognosis. The aims of this study were to analyze the immunoexpression of two DNA repair proteins, XPF and XRCC1, in lower lip squamous cell carcinoma (LLSCC) and oral tongue squamous cell carcinoma (OTSCC), and to investigate possible associations with clinical and histopathological parameters. The immunohistochemical expression of XPF and XRCC1 was analyzed semi-quantitatively in 40 cases each of LLSCC and OTSCC. The chi-squared test or Fisher's exact test, when appropriate, was used to investigate the association between expression of the proteins and clinicopathological characteristics. The cytoplasmic immunoexpression of XPF was high in OTSCC (95% of the cases analyzed) but low in LLSCC (52.5%). Among the clinicopathological parameters evaluated, a statistically significant association was observed between high nuclear expression of XRCC1 and the absence of regional lymph node metastasis in patients diagnosed with OTSCC (p=0.006). The high protein expression of XPF and XRCC1 in OTSCC and LLSCC suggests an important role in the development and progression of these tumors. Our study found an association between high nuclear expression of XRCC1 and the absence of loco-regional metastasis in cases diagnosed as OTSCC, suggesting a role of this protein in tumor progression.

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Section: Introductionmentioning

confidence: 99%

Immunohistochemical expression of DNA repair proteins in oral tongue and lower lip squamous cell carcinoma

et al. 2020

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“…Risk factors for regional recurrence in head and neck SCC have been widely evaluated. Fang et al [ 16 ] reported that the differentiation degree significantly affected the locoregional control in buccal SCC, and Ozkul et al [ 9 ] described tumor thickness as being positively correlated with recurrence; perineural invasion and invasion depth were also predictors for regional metastasis. [ 10 , 17 ] However, few authors have described the possible factors affecting regional metastasis in upper lip SCC.…”

Section: Discussionmentioning

confidence: 99%

“…[ 2 – 8 ] A number of variables, including tumor stage, perineural invasion, tumor subsite, and differentiation extent, have been described as being associated with the chance of mortality in head and neck SCC. [ 9 , 10 ] It is widely accepted that lymphatic metastasis is the most important factor in determining prognosis, and the survival rate can be reduced by 50% if there are cervical positive pathological nodes found at diagnosis. Although both Luna-Ortiz et al [ 5 ] and Zitsch et al [ 8 ] reported the apparent association between lymph node metastases and clinical-pathologic variables such as tumor stage and tumor differentiation, the detailed prognostic factors for lymphatic metastasis still remain unclear in upper lip cancer.…”

Section: Introductionmentioning

confidence: 99%

Management of and risk factors for regional recurrence in upper lip squamous cell carcinoma

Liu¹,

Wang

Pang

et al. 2017

Medicine

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Our goal was to evaluate the risk factors for regional recurrence in upper lip squamous cell carcinoma (SCC).A total of 109 patients with upper lip SCC were retrospectively enrolled. Clinical and pathologic information was collected and analyzed.Fifteen (13.8%) patients had a regional metastasis, 2 patients had parotid node metastasis, and no local or distant metastasis was noted. There was neck level I node metastasis in 15 (100%) patients. In multivariate analysis, invasion depth and degree of differentiation were significantly associated with regional metastasis. The 5- and 10-year disease-specific survival rate was 95.4% and 80.1%, respectively.Invasion depth and degree of differentiation have reliable value for predicting regional metastasis.

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“…Five-year survival rates are defined as the main attribute that describes the long-term prognosis of the tumour. Studies have reported that the five-year survival rate of lower lip cancer with cancer T stage of I to varies from 68.3% to 84.5%, with some studies drawing a direct link to pre-cancerous process of actinic cheilitis (Schüller et al, 2015;Ozkul et al, 2016). Pathology-associated death in case of lower lip cancer is usually due to metastatic tumorous formations in physiologically crucial neck organs.…”

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confidence: 99%

Diagnostics and Treatment Strategies of Early (T1) Lower Lip Cancer

Kornevs

2020

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Communicated by Andrejs SkaìersData from 35 patients were analysed to identify the main factors that may have predisposed the unfavourable clinical course in early diagnosed lower lip cancer. Of 35 patients who were sent to the Oncology Centre of Latvia, Rîga East University Hospital, with the diagnosis of early lower lip cancer, histologically diagnosis was confirmed for 22 patients. Sizes of the primary tumours were less than 2 cm (T1 size tumour). Vermilionectomy was carried out for 17 patients, wedge-or Vshaped resection was performed for 13 patients, and in five cases patients refused to receive surgical treatment and received radiation therapy instead. Review of the reports of the histological criteria for patients with aggressive course of the illness with relapses, regional metastases and also in cases of death, showed that vermilionectomy can be considered an effective diagnostic and therapeutic operation.

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Early stage squamous cell carcinoma of the lower lip: predictive factors for recurrence

Abstract: Surgical margin control is important to prevent local recurrence, especially in thicker tumours. In addition, neck metastasis is rare in early stage lower lip squamous cell carcinoma. A 'wait and see' policy might be preferred in early stage T1 lower lip squamous cell carcinoma cases.

Cited by 10 publications

References 22 publications

Immunohistochemical expression of DNA repair proteins in oral tongue and lower lip squamous cell carcinoma

Immunohistochemical expression of DNA repair proteins in oral tongue and lower lip squamous cell carcinoma

Management of and risk factors for regional recurrence in upper lip squamous cell carcinoma

Diagnostics and Treatment Strategies of Early (T1) Lower Lip Cancer

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