Management of and risk factors for regional recurrence in upper lip squamous cell carcinoma

Liu, Fei; Wang, Lei; Pang, Shuang; Kan, Quancheng

doi:10.1097/md.0000000000008270

Cited by 6 publications

(6 citation statements)

References 22 publications

(32 reference statements)

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“…Another study reported no significant difference in the local control and OS rates of patients with and without perineural invasion (23) . In a study involving 109 upper lip-cancer patients, regional recurrence was seen in 13.8% of the sample, while in a multivariate analysis, the invasion depth (p=0.003) and degree of differentiation (p=0.023) were associated with regional recurrence (24) . In another study, involving 144 lip-cancer patients, 84% were stage I-II, and clinical staging was related to a specific higher survival rate (p= 0.0049).…”

Section: Discussionmentioning

confidence: 95%

“…Previous studies have addressed the role of perineural invasion in the development of lymph node metastases (16) . A univariate analysis showed perineural invasion to be significantly associated with lymphatic node recurrence (24) . Another study reported no significant difference in the local control and OS rates of patients with and without perineural invasion (23) .…”

Section: Discussionmentioning

confidence: 99%

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Factors affecting the recurrence of early-stage lip cancer

Tuğrul

Isık²,

Yaprak³

2022

Int J Radiat Res

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Background: To determine the patterns of recurrence, prognostic factors and treatment outcomes in stage I-II lip cancer. Materials and Methods: A retrospective review was made of the data of 74 patients diagnosed with squamous cell carcinoma (SCC) of the lip between 2000 and 2009. Results: In all, 44 of the patients had stage I disease and 30 had stage II disease. Surgery was performed on the primary tumor in all patients, 15 received adjuvant radiotherapy and 23 underwent elective neck therapy. Recurrence occurred in 23 (31%) of the patients, with a mean time from surgery to relapse of 23 months. The frequency of nodal recurrence increased as tumor stage and depth increased. Adjuvant radiotherapy and neck dissection or elective radiotherapy decreased the risk of recurrence in tumors with depths of over 0.5 cm, with positive or close margins, and with perineural invasion. The median overall survival (OS) was 120 months and the median disease-free survival (DFS) was 83 months. A univariate analysis revealed tumor stage and depth, adjuvant radiotherapy, and neck treatment (lymphatic dissection + nodal irradiation) to affect DFS, while a multivariate analysis showed that elective neck radiotherapy improved DFS. Conclusion: Greater tumor stage and depth increase the risk of nodal recurrence in early-stage lip cancer, although the frequency of recurrence is decreased in such patients if treated with elective neck dissection and/or postoperative radiotherapy.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Factors affecting the recurrence of early-stage lip cancer

Tuğrul

Isık²,

Yaprak³

2022

Int J Radiat Res

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“…On the other hand, the incidence of squamous cell carcinoma of the lip is high. It constitutes 25% to 30% of all oral cancers which is much more common in the lower lip than the upper lip (16)(17)(18)(19). The role of cumulative ultraviolet radiation in squamous cell carcinoma of the lip is well established (19).…”

Section: Dear Editormentioning

confidence: 99%

Risks of Ghaderi’s Phenomenon

Ghaderi

2019

jsurgery

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“…In the present context, oral squamous cell carcinoma is responsible for more than 90% of oral cancers [2]. The lip squamous cell carcinoma (LSCC) comprises 10% of all cancers of the head and neck region and can be preceded by actinic cheilitis, a potentially malignant disorder [2,3].…”

Section: Introductionmentioning

confidence: 99%

Lip carcinoma mimicking keratoacanthoma: case reports

Lima

Viana

Souto

et al. 2022

RGO, Rev. Gaúch. Odontol.

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Oral amyloidosis is a disease characterized by extracellular and irreversible deposition of amorphous and fibrillar proteins in the oral cavity, being strongly associated with Multiple Myeloma. The objective of this study is to report a case of a 62-year-old woman diagnosed with Multiple Myeloma who, approximately 2 years after starting treatment for the underlying disease, presented a lesion on the lateral border of the tongue with exophytic growth, pinkish color, vascularized, painless, measuring 3cm in its largest diameter. After histopathological analysis through incisional biopsy, a final diagnosis of amyloidosis was obtained. As a local treatment, we opted for complete excision of the lesion. The patient evolved to death due to Multiple Myeloma influenced by the diagnosis of systemic amyloidosis. Oral amyloidosis is usually associated with the systemic presentation of the disease, making it necessary to conduct a thorough investigation of other organs. Its diagnosis is important since the prognosis is directly related and can negatively influence survival rates and treatment of the underlying disease.

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Management of and risk factors for regional recurrence in upper lip squamous cell carcinoma

Cited by 6 publications

References 22 publications

Factors affecting the recurrence of early-stage lip cancer

Factors affecting the recurrence of early-stage lip cancer

Risks of Ghaderi’s Phenomenon

Lip carcinoma mimicking keratoacanthoma: case reports

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