Early reperfusion and late clinical outcomes in patients presenting with acute myocardial infarction randomly assigned to primary percutaneous coronary intervention or streptokinase

Berrocal, Daniel; Cohen, Mauricio G.; Spinetta, Alejandro D; Ben, Marta García; Matas, Carlos A Rojas; Gabay, Jose M.; Magni, Jose; Nogareda, Gustavo; Oberti, Pablo; Schulz, Cristian Von; Doval, Hernán C.; Bazzino, Oscar; Cagide, Arturo; Oliveri, Raul; Grinfeld, Liliana

doi:10.1016/s0002-8703(03)00424-1

Cited by 18 publications

(9 citation statements)

References 35 publications

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“…This association has also been consistently shown in patients with moderate kidney disease (Anavekar et al, 2004;Schiele et al, 2006;Pitsavos et al, 2007). In addition, patients with renal dysfunction have an elevated risk of thrombosis and bleeding (Rabelink et al, 1994;Zachee et al, 1994;Berrocal et al, 2003), and are less likely to receive reperfusion therapy, antithrombotic drugs, and other conventional cardio protective therapy, which aggravate the outcomes of AMI patients.…”

Section: Introductionmentioning

confidence: 74%

Renal insufficiency is an independent predictor of in-hospital mortality for patients with acute myocardial infarction receiving primary percutaneous coronary intervention

Momin

Huo

et al. 2012

J. Zhejiang Univ. Sci. B

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Section: Introductionmentioning

confidence: 74%

Renal insufficiency is an independent predictor of in-hospital mortality for patients with acute myocardial infarction receiving primary percutaneous coronary intervention

Momin

Huo

et al. 2012

J. Zhejiang Univ. Sci. B

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“…In comparison with the earlier review,2 one additional trial19 was identified which had not been published at the time. In addition, full trial results were available for three studies that had previously been reported in abstract form only 20 – 22. …”

Section: Resultsmentioning

confidence: 99%

Assessing the effectiveness of primary angioplasty compared with thrombolysis and its relationship to time delay: a Bayesian evidence synthesis

Asseburg

Vergel

Palmer

et al. 2007

Heart

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Background: Meta-analyses of trials have shown greater benefits from angioplasty than thrombolysis after an acute myocardial infarction, but the time delay in initiating angioplasty needs to be considered. Objective: To extend earlier meta-analyses by considering 1-and 6-month outcome data for both forms of reperfusion. To use Bayesian statistical methods to quantify the uncertainty associated with the estimated relationships. Methods: A systematic review and meta-analysis published in 2003 was updated. Data on key clinical outcomes and the difference between time-to-balloon and time-to-needle were independently extracted by two researchers. Bayesian statistical methods were used to synthesise evidence despite differences between reported follow-up times and outcomes. Outcomes are presented as absolute probabilities of specific events and odds ratios (ORs; with 95% credible intervals (CrI)) as a function of the additional time delay associated with angioplasty. Results: 22 studies were included in the meta-analysis, with 3760 and 3758 patients randomised to primary angioplasty and thrombolysis, respectively. The mean (SE) angioplasty-related time delay (over and above time to thrombolysis) was 54.3 (2.2) minutes. For this delay, mean event probabilities were lower for primary angioplasty for all outcomes. Mortality within 1 month was 4.5% after angioplasty and 6.4% after thrombolysis (OR = 0.68 (95% CrI 0.46 to 1.01)). For non-fatal reinfarction, OR = 0.32 (95% CrI 0.20 to 0.51); for non-fatal stroke OR = 0.24 (95% CrI 0.11 to 0.50). For all outcomes, the benefit of angioplasty decreased with longer delay from initiation. Conclusions: The benefit of primary angioplasty, over thrombolysis, depends on the former's additional time delay. For delays of 30-90 minutes, angioplasty is superior for 1-month fatal and non-fatal outcomes. For delays of around 90 minutes thrombolysis may be the preferred option as assessed by 6-month mortality; there is considerable uncertainty for longer time delays.

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“…Furthermore, in comparison to thrombolytics, primary PCI, results in more effective ST resolution, better IRA patency and reduced infarct size [22]. Logically, patients with STEMI who are treated with primary PCI should have a lower incidence of CS compared to those treated with thrombolytics.…”

Section: Discussionmentioning

confidence: 99%

Age adjusted nationwide trends in the incidence of all cause and ST elevation myocardial infarction associated cardiogenic shock based on gender and race in the United States

Movahed

Khan

Hashemzadeh

2015

Cardiovascular Revascularization Medicine

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Early reperfusion and late clinical outcomes in patients presenting with acute myocardial infarction randomly assigned to primary percutaneous coronary intervention or streptokinase

Cited by 18 publications

References 35 publications

Renal insufficiency is an independent predictor of in-hospital mortality for patients with acute myocardial infarction receiving primary percutaneous coronary intervention

Renal insufficiency is an independent predictor of in-hospital mortality for patients with acute myocardial infarction receiving primary percutaneous coronary intervention

Assessing the effectiveness of primary angioplasty compared with thrombolysis and its relationship to time delay: a Bayesian evidence synthesis

Age adjusted nationwide trends in the incidence of all cause and ST elevation myocardial infarction associated cardiogenic shock based on gender and race in the United States

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