Renal insufficiency is an independent predictor of in-hospital mortality for patients with acute myocardial infarction receiving primary percutaneous coronary intervention

Li, Jianping; Momin, Mohetaboer; Huo, Yong; Wang, Chunyan; Zhang, Yan; Gong, Yanjun; Liu, Zhaoping; Wang, Xingang; Zheng, Bo

doi:10.1631/jzus.b1201005

Cited by 11 publications

(11 citation statements)

References 15 publications

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“…For patients with STEMI treated with primary PCI, it is known that renal insuffi ciency is an independent predictor of in-hospital mortality [37,38]. The results of the present study did not confi rm it.…”

Section: Discussioncontrasting

confidence: 89%

Impact of patient-related and treatment-related factors on in-hospital mortality of patients with ST-elevation myocardial infarction: Data of Russian Acute Coronary Syndrome Registry

et al. 2014

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Please cite this article as: O.M. Posnenkova, et al., Impact of patient-related and treatment-related factors on in-hospital mortality of patients with ST-elevation myocardial infarction: Data of Russian Acute Coronary Syndrome Registry, Cor et Vasa 56 (2014) e217-e227 as published in the online version of Cor et Vasa available at SOUHRN Cíl: Hodnotili jsme vztah mezi farmakoterapií hospitalizovaných pacientů, reperfuzní léčbou a mortalitou pacientů s infarktem myokardu s elevací úseku ST (STEMI) v Ruské federaci. Metody: Ve studii byly retrospektivně analyzovány klinické údaje 25 682 pacientů se STEMI, zařazených do registru v období 2010-2011. Hodnotilo se provádění základních léčebných intervencí v rámci doporučených postupů. Včasnost provedení reperfuzní léčby se hodnotila pomocí následujících klinických parametrů amerických odborných společností ACC/AHA (2008): doba do provedení fi brinolytické léčby, doba do provedení perkutánní koronární intervence (PCI) a doba do zahájení reperfuzní léčby. Vztahy mezi různými léčebnými intervencemi během hospitalizace a rizikem nemocniční mortality pacientů se STEMI byly hodnoceny pomocí multivariantního logistického modelu a Coxova regresního modelu s použitím charakteristik a komorbidit pacientů. Výsledky: Průměrný věk pacientů byl 63 (55-74) let; ve 34 % šlo o ženy. Byl zjištěn statisticky významný rozdíl mezi přeživšími a zemřelými pacienty ve většině demografi ckých, anamnestických parametrů i v jejich klinických projevech a léčbě. Léčba inhibitory ACE, blokátory receptorů AT 1 pro angiotensin II, beta-blokátory a statiny v nemocnici byla významně spojena ( 2 = 482,1; p < 0,0001) s nižší nemocniční mortalitou. Prognostická hodnota reperfuzní léčby a parametry jejího včasného provedení statistické významnosti nedosáhly (p ≥ 0,05 pro Waldův test pro každý faktor). Závěr: Léčba STEMI inhibitory ACE, blokátory receptorů AT 1 pro angiotensin II, beta-blokátory a statiny během hospitalizace (ne nutně při příjmu) ovlivňuje nemocniční mortalitu stejnou měrou jako klinický stav pacienta při příjmu. Reperfuze a její provádění jsou dodatečnými faktory nepřímo přispívajícími k riziku nemocniční mortality pacientů se STEMI. ABSTRACT Objective: We examined relationships between inpatient medical treatment, reperfusion therapy and in-hospital mortality among patients with ST-elevation myocardial infarction (STEMI) in Russia. Methods: Clinical information about 25,682 patients with STEMI enrolled in the 2010-2011 registry was included retrospectively in the study. Performance of the key guideline-recommended treatment interventions was assessed. Timeliness of reperfusion therapy was evaluated with the help of the following ACC/AHA clinical measures (2008): Time to fi brinolytic therapy, Time to primary percutaneous coronary intervention (PCI) and Reperfusion therapy. Multivariate logistic and Cox's regression models were used to assess the relationship between different in-hospital treatment interventions and the risk of in-hospital death among patients with STEMI under the control ...

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Section: Discussioncontrasting

confidence: 89%

Impact of patient-related and treatment-related factors on in-hospital mortality of patients with ST-elevation myocardial infarction: Data of Russian Acute Coronary Syndrome Registry

et al. 2014

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“…[12] However, the in-hospital mortality rate in the CKD group was higher than that previously reported (21.32% vs 8.7%). [11] This might be because our study population was enrolled from real-world setting without preselection. In contrast, patients with severe renal dysfunction were excluded from the study conducted by Li et al [11] In addition, all patients in the previous study had received primary PCI treatment, compared with 6.09% in our study.…”

Section: Discussionmentioning

confidence: 99%

The dose-response association between estimated glomerular filtration rate and prognosis of patients with ST-segment elevation myocardial infarction from rural areas of China's Liaoning province

Qi²,

Zhang

et al. 2017

Medicine

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We aimed to investigate the dose-response associations between chronic kidney disease (CKD), and short and long-term cardiovascular outcomes, to characterize these associations by drawing dose-response curves based on a Chinese rural ST-segment elevation myocardial infarction (STEMI) population.In all, 1067 patients with STEMI were consecutively enrolled from 12 secondary hospitals of China's Liaoning province (from June 2009 to June 2010 and January 2015 to December 2015). The follow-up was regularly performed by telephone. Patients were grouped by estimated glomerular filter rate (eGFR): normal, eGFR ≥90 mL/min/1.73 m; mild CKD, 60 to 90 mL/min/1.73 m; CKD, <60 mL/min/1.73 m. Adjusted logistic or Cox regression models were employed to compare short and long-term cardiovascular outcomes across different eGFR groups. Dose-response curves were plotted using restricted cubic spline functions.About 18.46% of the STEMI patients had CKD. Patients with CKD were more likely to suffer from other comorbidities, but less likely to receive evidence-based therapies. CKD was independently associated with in-hospital mortality and major adverse cardiac events (MACE) as compared with patients with normal renal function (for in-hospital mortality, adjusted odds ratio [OR] 2.39, 95% confidence interval [CI] 1.18-4.85, P = .02; for in-hospital MACE, adjusted OR 2.01, 95% CI 1.09-3.70, P < .01). Likewise, CKD was significantly associated with long-term mortality as well (CKD vs normal, adjusted hazard ratio 2.55, 95% CI 1.17-5.57, P = .02). The dose-response associations between eGFR, and short and long-term cardiovascular outcomes were found to be linear (all with P values for nonlinear associations >.05).CKD is an independent predictor of worse in-hospital and long-term clinical outcomes. The assessment of eGFR is essential to enable risk stratification, tailored therapy, and early and aggressive management.

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“…Another similar study done by Jian-Ping et al, 14 included 420 patients of ACS found that death was 1.67% in group A, 8.20% in group B and 20% in group C (p-value 0.001). In comparison to above study, in our study there is more mortality in group A and C, and almost same mortality in group B.…”

Section: Discussionmentioning

confidence: 63%

Renal Dysfunction as an Independent Predictor in Hospital Mortality After Acute Coronary Syndrome

Sharma¹,

Singh²,

Kumar³

et al. 2017

jemds

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BACKGROUNDAcute coronary syndrome (ACS) included the spectrum of conditions from unstable angina, non-ST segment elevation myocardial infarction (NSTEMI), ST segment elevation myocardial infarction (STEMI) and these serious cardiovascular conditions causes major morbidity and mortality throughout the world. In various studies, it has been found that renal dysfunction in patient with ac ute coronary syndrome act as independent risk factor and cases increased mortality and morbidity. It is found that patient with moderate and severe renal dysfunction were almost two to four time more likely to die compared to patients with normal or minimal rena l dysfunction. Renal function has been shown in epidemiological studies and clinical trials to be independent predictor of survival.

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Renal insufficiency is an independent predictor of in-hospital mortality for patients with acute myocardial infarction receiving primary percutaneous coronary intervention

Abstract: Renal insufficiency is an independent predictor of in-hospital mortality for patients hospitalized with ASTEMI treated with primary PCI.

Cited by 11 publications

References 15 publications

Impact of patient-related and treatment-related factors on in-hospital mortality of patients with ST-elevation myocardial infarction: Data of Russian Acute Coronary Syndrome Registry

Impact of patient-related and treatment-related factors on in-hospital mortality of patients with ST-elevation myocardial infarction: Data of Russian Acute Coronary Syndrome Registry

The dose-response association between estimated glomerular filtration rate and prognosis of patients with ST-segment elevation myocardial infarction from rural areas of China's Liaoning province

Renal Dysfunction as an Independent Predictor in Hospital Mortality After Acute Coronary Syndrome

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