Early outcome of three cases of melanotic neuroectodermal tumour of infancy

Cytologic Interpretation of Melanotic Neuroectodermal Tumour of Infancy Involving Cranial Bones: Clue to Diagnosis

“…It is well known to be benign in nature but the rapid expansion can be destructive and is harmful for the patient. Approximately 1% of tumours are malignant, only rarely producing metastasis [12]. Yoo et al, recently described a case of malignant MNTI in a 28-month-old female child where metastatic deposits were found in inguinal sac [13].…”

Urgent maxillectomy in infants for rare infantile maxillary tumors

“…Clinical examination of any infant below 1 year with a pigmented mass in the maxilla should direct the attention for the diagnosis of MNTI. In addition, incisional biopsy followed by histopathological examination by a competent pathologist with head and neck pathology experience is advised [5]. The histological features include 2 cell populations; Large polygonal epithelioid cells resembling melanocytes, with scattered intracellular brown granular pigmentation (melanin) and smaller neuroblast-like round cells in a stroma of fibrous tissue containing fibroblasts.…”

Cellular blue nevus (CBN) lymph node metastases of the neck with no primary skin lesion: A case report and review of literature

“…To make the diagnosis clinical features such as the congenital or acquired nature of the lesion, it's duration and the patient's age (e.g. melanotic neuroectodermal tumour of infancy: Melissari et al, 1988;Butt et al, 2009) …”

“…The immunohistochemical expression of S-100, MART-1 and gp100 (HMB-45) is a characteristic feature of the CBN (Zembowicz and Mihm, 2004) and essentially excludes a desmoplastic melanoma (HMB-45 negative) or a melanotic neuroectodermal tumour (S-100 negative, Butt et al, 2009). In our case the tumour cells showed no significant mitotic activity with only 1e2 mitoses per 20 high-power fields.…”