Cytologic Interpretation of Melanotic Neuroectodermal Tumour of Infancy Involving Cranial Bones: Clue to Diagnosis

Kar, Asaranti; Biswal, Priyadarshini; Behera, Suresh Kumar; Dhal, Ipsita; Surabhi, .

doi:10.7860/jcdr/2015/13691.6494

Cited by 3 publications

(5 citation statements)

References 11 publications

(9 reference statements)

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“…The differential diagnosis is quite broad but must be separated from other pediatric “small round cell” neoplasms such as neuroblastoma, Ewing's sarcoma, rhabdomyosarcoma, desmoplastic small round cell tumor, malignant melanoma, and lymphoma. 14 Recognition of its biphasic morphology features is essential to avoid misdiagnosis. Negative immunohistochemical staining for PGP 9.5, PHOX2B, NKX2.2, FLI1, CD99, desmin, myogenin, SOX10, CD45, and TDT (DNTT) can rule out those possibilities.…”

Section: Discussionmentioning

confidence: 99%

Melanotic Neuroectodermal Tumor of Infancy in the Epididymis: A Case Report

et al. 2023

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Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, benign neoplasm of neural crest origin that predominantly involves the craniofacial region, involvement of the epididymis being extremely rare, with about 30 cases reported. We report an unusual case of a 5-month-old male with MNTI in the epididymis. The patient underwent orchiectomy. Half a year later, there was no sign of recurrence. Whether preoperative examination or intraoperative frozen examination, the tumor may easily be misdiagnosed as malignancy. Melanotic neuroectodermal tumor of infancy should be included in differential diagnosis in infants presenting with fast-growing scrotal swelling.

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Section: Discussionmentioning

confidence: 99%

Melanotic Neuroectodermal Tumor of Infancy in the Epididymis: A Case Report

et al. 2023

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“…This malignant variant spreads by direct invasion into adjacent tissue but can also metastasize to regional and distant sites such as lymph nodes, liver and bone [4]. Histologically, malignant MNTI demonstrates increased mitosis > 2 per 10 high power field, hypercellularity and focal necrosis [24][25][26][27]. The predominant cell type in metastatic deposits are the neuroblast-like cells [23,24].…”

Section: Discussionmentioning

confidence: 99%

“…Hematological tests for catecholamines and urinary testing for vanillymandelic acid can sometimes be elevated as a result of the neural crest origin of the tumor [25]. Levels should be obtained in order to assist with treatment planning but it has no influence on the biologic activity of the tumor.…”

Section: Discussionmentioning

confidence: 99%

A Case Report on Melanotic Neuroectodermal Tumor of Infancy and Review of the Literature

Jugmohansingh¹,

Medford²,

Sharma³

et al. 2020

AJSCR

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Melanotic neuroectodermal tumor of infancy (MNTI) is a rare, benign neoplasm of neural crest origin that most commonly occurs in the first year of life. The craniofacial area is affected 90% of the time with the maxilla being the affected site in the majority of cases. It has a recurrence rate of up to 27% and is associated with malignant transformation in up to 6.5% of patients. The current case describes the clinical presentation and management of a 3-month old male infant with MNTI of the maxilla. Following initial presentation, the tumor grew rapidly to compromise the aerodigestive tract. Surgical resection was performed and the adjacent bone was burred. There has been no clinical recurrence over a 4-year period of follow up.

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“…Other sites known to be involved are the mandible, mediastinum, long bones, uterus, skull, brain, and epididymis [1, 2]. It occurs in infancy and has no sex predilection [2].…”

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confidence: 99%

“…Retinal anlage tumor is a rare tumor most commonly affecting the maxilla [1]. Other sites known to be involved are the mandible, mediastinum, long bones, uterus, skull, brain, and epididymis [1, 2].…”

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confidence: 99%