Cellular blue nevus (CBN) lymph node metastases of the neck with no primary skin lesion: A case report and review of literature

Calvarial malignant melanotic neuroectodermal tumour of infancy presenting with widespread intracranial metastasis

“…Our patient had neither lymph node or liver metastasis, nor did she have unusually high serum levels of catecholamines, routinely assayed in patients with malignant MNTI (Butt et al, 2009;Omodaka et al, 2010;Scheller et al, 2010). The histological appearance of the lesion did not necessitate the performance of immunological tests such as S-100, HMB 45 and Ki-67 as an index for proliferation (Butt et al, 2009;Scheller et al, 2010).…”

“…Microscopically MNTIs are characterized by larger polygonal epithelioid cells which are described as melanocytes producing variable deposits of melanin, smaller neuroblast-like round cells and stromal fibroblasts (Atkinson et al, 1989;George et al, 1995;Neven et al, 2008). The MNTI cells are cytokeratin and HMB 45 (human melanoma block) positive and S-100 negative (Butt et al, 2009;Scheller et al, 2010).…”

Cellular blue nevus of the vulva mimicking Bartholin’s gland abscess in a 15-year-old girl: a case report

“…During 18 months' clinical follow-up, recurrence was not observed. Complete surgical excision of CBN should be the choice of treatment and follow-up should be done carefully because malign transformation of an intracranial CBN and cervical lymph node metastases of the neck with no primary skin lesion by a CBN have been reported [9,10]. In summary, detailed and careful evaluation of cytologic atypia is mandatory before ruling out malignancy in CBN cases (Fig.…”

“…Although it usually occurs in skin, it has been reported in other locations such as oral mucosa, sclera, vagina, cervix, endometrium, myometrium, ovary, prostate, spermatic cord, pulmonary hilus, orbit, conjunctiva, maxillary sinus, breast, scalp, neck, meninges, and lymph nodes [3][4][5][6][7][8][9][10]. In gynecologic tract, the majority of these challenging lesions are common type and arise mainly in the endocervix followed by the vagina.…”

Amelanotic Cellular Blue Nevus: An Unusual Iris Localization

“…Rare cases of common blue nevi have been reported in the vagina [2], the uterine cervix [3], the Mullerian tract [4], the spermatic cord [5], the oral mucosa [6, 7], the prostate [8], and the bronchus [9] in the brain [10] and in the lymph node [11]. No eye localizations are described in literature.…”