Early effects of sodium iodate injection on ERG in mice

Abstract

The electroretinogram (ERG) was recorded in 15 ICR albino mice before and 2, 4 and 24 h after injection of 40 mg/kg of NaIO3 and the results were compared with the corresponding ultrastructural findings. Both a- and b-wave amplitudes decreased at 2 h after injection and increased at 4 h to the levels before injection and further increased at 24 h after injection. The b-wave threshold intensity increased by 2.1 log units at 2 h after injection. Thereafter, it decreased once at 4 h and significantly increased at 24 h by 3.4 log units. Electron microscopic examination showed swollen cytoplasmic organelles of the retinal pigment epithelial cells at 4 h after injection. It was thus demonstrated that an early effect of NaIO3 on the electrical response of the mouse retina was more conspicuous than histopathological changes.

Deficiency of thyroid hormone receptor protects retinal pigment epithelium and photoreceptors from cell death in a mouse model of age-related macular degeneration

“…Using a sodium iodate (NaIO 3 )-induced mouse model of AMD [24][25][26], we recently showed that treatment with antithyroid drug protected RPE and photoreceptors from oxidative damage and cell death/necroptosis and preserved retinal function [27]. The present work expanded this research by investigating the involvement of TH receptors (THRs) and the contribution of the receptor subtypes.…”

Electrophysiologic and Morphologic Strain Differences in a Low-Dose NaIO3-Induced Retinal Pigment Epithelium Damage Model

“…This effect is not noted in the literature, except by Sato's group, which identified supernormal transient b-waves in NaIO 3 -treated mice. [44][45][46] We extended the observations from Sato et al to include earlier times after injection, lower doses of NaIO 3 , and additional mouse strains. We further found that scotopic a-, b-, and c-waves all transiently increase, and outcomes vary with strain and with the time of assessment, after injection.…”

Morphologic and Clinical Effects of Subretinal Injection of Indocyanine Green and Infracyanine Green in Rabbits

“…27 Intravitreal and systemic injection of sodium iodate in mice, cats, and rabbits has induced a decrease in c-wave amplitude on ERG as well as damage to RPE/photoreceptor organelles and cells. [28][29][30][31][32][33][34] The retinotoxic effects of iodine and derivates are likely due to their strong oxidizing and reducing activity in biochemical reactions, which generate numerous free radicals and secondary DNA-base fragmentation. 27,35 In the second instance, lesser retinal damage after IfCG application may be due to the osmolarity profile.…”