The electroretinogram (ERG) was recorded in 15 ICR albino mice before and 2, 4 and 24 h after injection of 40 mg/kg of NaIO3 and the results were compared with the corresponding ultrastructural findings. Both a- and b-wave amplitudes decreased at 2 h after injection and increased at 4 h to the levels before injection and further increased at 24 h after injection. The b-wave threshold intensity increased by 2.1 log units at 2 h after injection. Thereafter, it decreased once at 4 h and significantly increased at 24 h by 3.4 log units. Electron microscopic examination showed swollen cytoplasmic organelles of the retinal pigment epithelial cells at 4 h after injection. It was thus demonstrated that an early effect of NaIO3 on the electrical response of the mouse retina was more conspicuous than histopathological changes.
Pattern reversal visually evoked cortical potentials were recorded from 70 normal volunteers, aged from 4 to 70 years. Eleven reversal frequencies between 1 and 20 rev/sec were presented. The progressive reduction in the amplitude of the P100 component with age for lower frequency ranges was shown up to the age decade of 30-39 years and the temporal tuning curve became a constant pattern after 40 years. However, there was a trend that the maxima of the tuning curve shifted toward lower frequencies with age after 30 years.
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