Abstract:For early detection of hepatocellular carcinoma (HCC), real-time ultrasonography (US) was performed prospectively in 528 patients, including 236 with cirrhosis, 81 with chronic hepatitis, 168 asymptomatic hepatitis B surface antigen carriers, and 43 with a family history of HCC. Simultaneous measurement of serum alpha-fetoprotein (AFP) level was also done. In addition, 233 patients had regular controls at 3- to 6-month intervals, with an average follow-up period of 1.4 years. On initial screening, a total of 1… Show more
“…23,28,35,36,40,42 This did not translate into a comparable resection rate. In the majority of studies, the overall surgical resection rate varied from 29 to 54%.…”
Section: Surveillance Should Reduce Mortality From the Diseasementioning
confidence: 98%
“…To overcome this problem, surveillance has been extended to include patients with noncirrhotic chronic viral hepatitis as well as those with overt cirrhosis. The overall reported annual detection rate of HCC in surveillance studies, which included individuals with chronic hepatitis in addition to cirrhosis, is 0.8% to 4.1% [34][35][36][37][38][39][40] (Table 1).…”
Section: The Target Population Must Be Easily Identifiablementioning
confidence: 99%
“…In the majority of studies, the overall surgical resection rate varied from 29 to 54%. 22,[25][26][27][35][36][37]40,42 Failure to undertake hepatic resection was due mainly to age, patient wishes, cirrhosis, and impaired synthetic function or a poor general medical condition. 34,42 The preference for hepatic resection rather than liver transplantation in all the studies was not discussed.…”
Section: Surveillance Should Reduce Mortality From the Diseasementioning
“…23,28,35,36,40,42 This did not translate into a comparable resection rate. In the majority of studies, the overall surgical resection rate varied from 29 to 54%.…”
Section: Surveillance Should Reduce Mortality From the Diseasementioning
confidence: 98%
“…To overcome this problem, surveillance has been extended to include patients with noncirrhotic chronic viral hepatitis as well as those with overt cirrhosis. The overall reported annual detection rate of HCC in surveillance studies, which included individuals with chronic hepatitis in addition to cirrhosis, is 0.8% to 4.1% [34][35][36][37][38][39][40] (Table 1).…”
Section: The Target Population Must Be Easily Identifiablementioning
confidence: 99%
“…In the majority of studies, the overall surgical resection rate varied from 29 to 54%. 22,[25][26][27][35][36][37]40,42 Failure to undertake hepatic resection was due mainly to age, patient wishes, cirrhosis, and impaired synthetic function or a poor general medical condition. 34,42 The preference for hepatic resection rather than liver transplantation in all the studies was not discussed.…”
Section: Surveillance Should Reduce Mortality From the Diseasementioning
“…34 Accordingly, we proposed screening asymptomatic HBsAg carriers, patients with chronic hepatitis, and those with cirrhosis at defined intervals with serum a-fetoprotein and abdominal ultrasonography. 34,35 The screening yielded many patients with small HCC. Because of the smaller tumor size and a better liver function, the resectable cases increased remarkably.…”
Section: Early Detection Of Hepatocellular Carcinomamentioning
confidence: 99%
“…Because cirrhosis is the most dominant risk factor of HCC, 35,55 HBsAg-positive cirrhosis is an ideal target to explore. Dr. Yun-Fan Liaw led a randomized study showing that lamivudine could reduce the occurrence of HCC in HBsAg-positive patients with cirrhosis.…”
Section: Prevention Of Hcc By Antiviral Therapiesmentioning
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