Early calcification of the aortic Mitroflow pericardial bioprosthesis in the elderly

Abstract

The Mitroflow A12 pericardial bioprosthesis provides less than optimal performance in elderly patients.

Accelerated Degeneration of a Bovine Pericardial Bioprosthetic Aortic Valve in Children and Young Adults

“…The median time from valve placement to explantation was ≈3 years in that study. A recent report by Alvarez and colleagues 28 in elderly patients found that 98% of Mitroflow valve failures involved extensive intrinsic calcification leading to leaflet stiffness and valve stenosis. Approximately one-third of valves continued to function normally at 8 years after implantation.…”

Clinical and Hemodynamic Performance of the Sorin Mitroflow Pericardial Bioprosthesis

“…The clinical performance of the Mitroflow pericardial bioprosthesis has been reported by several investigative groups (Table 1) ( Benhameid et al, 2008;Minami et al, 2005;Yankah et al, 2008;Yankah et al, 2010;Alvarez et al, 2009;ISTHMUS investigators, 2011;Conte et al, 2010;). Actuarial freedom from structural valve deterioration provides an assessment of durability while actual cumulative incidence analysis documents structural valve deterioration in patient groups, such as elderly patients, who are subject to competing risks of death.…”

Bioprosthetic Aortic Valve Replacement in the Young

“…[11][12][13] Nonetheless, even with these caveats in mind, there are suggestions that the Mitroflow valve is particularly prone to relatively early calcification, even in the elderly. [14][15][16] Indeed, in a recent state-of-the-art review, Rahimtoola 11 suggested that the Mitroflow is prone to "very early" structural valve deterioration, comparing it unfavorably with the Edwards pericardial valve.…”