Early bone formation in mini‐lateral window sinus floor elevation with simultaneous implant placement: An in vivo experimental study

Abstract

Objective To investigate the early bone formation in beagles with mini‐lateral window sinus floor elevation and simultaneous implant placement. Material and methods Six beagles were selected for the split‐mouth design procedures. In each animal, one maxillary recess received a 5 mm‐diameter mini‐round lateral osteotomy (test group), and the contralateral maxillary recess received a large rectangular osteotomy (10 mm long and 8 mm wide), (control group). Simultaneous implant installation was executed on bilateral maxillary recesses. Tetracycline and calcein dyes were administered on the 14th, 13th days and the 4th, 3rd days prior to sacrifice, respectively. After 8 weeks of healing, the beagles were euthanized for fluorescent labeling and histomorphometric analyses. Results In both groups, new bone formation initiated from the circumferential native bone of the maxillary recesses and extended toward the central sub‐recess cavities. The maxillary recesses with the mini‐window procedures exhibited superior mineral apposition rate, bone formation rate, and the percentage of new bone area to those of the group exposed to large osteotomy procedure (p < .05). While there was no significant difference in the value of bone‐to‐implant contact, the mini‐window group displayed a tendency for an increase in this aspect (p > .05). Bone formation rate and new bone amount were not statistically correlated with bone‐to‐implant contact (p > .05). Conclusion The hypothesis that mini‐lateral window sinus floor elevation with simultaneous implant placement would improve early new bone formation in augmented sinus compared with large lateral window procedure is accepted.

Repositioning of the bone window in lateral sinus floor elevation with simultaneous implant placement: A retrospective radiographic study

“…In the current application of LSFE, a common procedure for preparing the accessing window is to directly grind the lateral wall bone using the rotary diamond round bur, but the remaining lateral defect is reported to have an adverse effect on endo‐sinus bone healing (Yu & Qiu, 2017). In addition, current studies have shown that a smaller lateral window contributes to the early bone formation compared with a larger window whether undergoing grafting or not (Aldahouk et al, 2021; Zhu et al, 2021), which confirms the role of the lateral bone wall in endo‐sinus bone augmentation. Besides, the residual lateral defect caused by the round bur would lead to the compensation of graft material to fill the lateral antrostomy hole, which might affect the endo‐sinus augmentation effect of LSFE (Zhou et al, 2021; Figure 1a).…”

“…A recent histomorphometric study in rabbits found that repositioning of the bone window could accelerate endo‐sinus bone generation and generate more new bone (31.28 ± 3.51% vs. 21.74 ± 2.40%; p < .05) and mature bone (27.37 ± 5.45% vs. 13.02 ± 3.69%; p < .05) at 8 weeks compared with the collagen membrane‐covered group (Moon et al, 2014), proving the osteoinductive efficacy of the lateral wall bone. Other studies assessing the effect of the size of lateral wall antrostomy on endo‐sinus bone formation also confirmed the above conclusion that lateral wall bone had a role of osteoinduction and acted as the source of osteogenesis, providing growth factors and a blood supply for bone regeneration (Aldahouk et al, 2021; Avila‐Ortiz et al, 2012; Yu & Qiu, 2017; Zhu et al, 2021). The above studies were in agreement with the results in this study, demonstrating that the repositioned bone wall would be beneficial to the graft stability, especially to the region near the bone window.…”

The impact of polydeoxyribonucleotide on early bone formation in lateral-window sinus floor elevation with simultaneous implant placement

“…Incomplete corticalisation was shown despite bone bridging, as bony wall regeneration occurred surrounding the lateral window in both groups ( Figure 3D ). This may have been affected by the size of the lateral window [ 40 ] and insufficient healing time during the investigation of the osteogenic potential of PDRN in the early stage. Third, new bone formation and bone remodelling were observed in the augmented area in both groups without any specific side effects.…”

Simvastatin-hydroxyapatite coatings prevent biofilm formation and improve bone formation in implant-associated infections

“…The rats were injected with 20 mg/kg calcein green (Sigma, USA) via the tail vein 14 and 4 days before euthanasia [ 37 ]. The undecalcified sections of right distal femur around the implants were obtained (EXAKT Cutting & Grinding System, Germany) [ 9 , 38 ].…”