Simvastatin-hydroxyapatite coatings prevent biofilm formation and improve bone formation in implant-associated infections

Dynamic covalent nano-networks comprising antibiotics and polyphenols orchestrate bacterial drug resistance reversal and inflammation alleviation

“…A biofilm is a cluster of bacteria and their self-produced extracellular polymeric matrixes [ [54] , [55] , [56] ]. Biofilm matrixes protect the embedded inhabitants from microenvironmental variations and antibiotic exposure [ [57] , [58] , [59] ]. In this regard, biofilms account for over 80% of bacterial infections and contribute significantly to the drug resistance of bacteria [ 5 , 41 ].…”

Controlling the size of GO in GO/nAg nanocomposite coatings on orthodontic nickel–titanium alloy toward excellent anti-corrosion, antibacterial, and tribological properties

“…These findings were in line with previous research, which indicated that electrodeposition technology could generate coatings with high repeatability and stability. 46 Under the 3 mm dislocation for 4 weeks, the surfaces of all coated samples were intact, with no significant peeling or cracking (Fig. 5G).…”

Phytic Acid-Promoted Deposition of Gold Nanoparticles with Grafted Cationic Polymer Brushes for the Construction of Synergistic Contact-Killing and Photothermal Bactericidal Coatings

“…Owing to the rapid advancements in modern medicine, a myriad of biomedical materials have been developed and used at the clinical level to meet the various medical needs. Most of these functional biomaterials have the desirable internal strength, durability, and biocompatibility, but lack inherent antimicrobial properties, and often suffer from the risk of fatal bacterial infections. − Bacteria and other microorganisms could easily adhere and multiply on biomaterials surfaces, even form highly organized multicellular clustered biofilms. − Compared to planktonic bacteria, the pathogenic biofilms are difficult to treat because of their immune escape ability and prevalence of multidrug resistance (MDR). − Therefore, the lack of an antibacterial effect in biomedical materials has hindered their practical applications and seriously threatened public health. It is of great importance to develop a simple and practical surface modification strategy that could endow the biomedical materials with good antibacterial property and biocompatibility …”