Early Bacteremia After Solid Organ Transplantation

Linares, Laura; García-Goez, José Fernando; Cervera, Carlos; Almela, Manuel; Sanclemente, G.; Cofan, Frederic; Ricart, M. J.; Navasa, Miquel; Moreno, Asunción

doi:10.1016/j.transproceed.2009.06.079

Cited by 119 publications

(90 citation statements)

References 11 publications

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“…BSI caused by Acinetobacter strains only susceptible to colistin, vancomycin-resistant enterococci and carbapenemresistant Enterobacteriaceae are emerging problems in our centre in the last five years in accordance with previous studies (3,15,16). Carbapenem resistance in Enterobacteriaceae are due to OXA-48 type carbapenemases in Turkey.…”

Section: Discussionsupporting

confidence: 81%

“…ESBL production among E. coli and Klebsiella spp. isolates is also a large problem in Spain; nearly half of the isolates were reported to be ESBL positive (3). The percentage of ESBL production among E. coli isolates was 44.6% and 47.6% among K. pneumoniae isolates in Turkish intensive care units (ICU) (13).…”

Section: Discussionmentioning

confidence: 99%

“…The recipients of liver transplantation had a higher incidence of BSI compared to the recipients of either kidney or heart transplantation (2,3). The aetiology of bacteraemia in SOT recipients has changed decade by decade.…”

Section: Introductionmentioning

confidence: 99%

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Bloodstream Infections among Solid Organ Transplant Recipients: Eight Years’ Experience from a Turkish University Hospital

Yeşilkaya¹,

Azap²,

Demirkaya³

et al. 2013

Balkan Med J

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Background: Bloodstream infections (BSI) are frequently seen after solid organ transplantation. The incidence of bloodstream infections differs among the types of transplantation. The microbiological features and antimicrobial resistance patterns change from centre to centre. Aims: To evaluate the incidence and spectrum of aetiological agents of bloodstream infections among solid organ transplantation recipients.Study Design: Retrospective descriptive study.Methods: Medical records of solid organ transplant recipients in the period between January 1 st 2004 and August 15 th 2012 were assessed retrospectively. The study population comprised 927 (64 heart, 556 kidney, 307 liver) consecutive recipients. Bloodstream infections were divided into three groups according to the onset time of bloodstream infections after transplantation: early, mid-term and late. The incidence and microbiological features of bloodstream infections were evaluated.Results: The number of bloodstream infection episodes was 317 in 191 recipients which was distributed as 228 (72%) in liver, 70 (22%) in kidney and 19 (6%) in heart transplantation. Ninety-eight 98 (30.9%) of the episodes were diagnosed within the early period, 134 (42.3%) within the mid-term and 85 (26.8%) in the late period. Early and mid-term bloodstream infections were seen statistically more often in liver than in kidney or heart transplantation (p=0.01 and p=0.031, respectively). Late bloodstream infections were also common in liver transplant recipients which was not statistically significant (p=0.229).Conclusion: Liver transplant recipients are at the highest risk for developing BSI after transplantation in early, mid-term and late periods.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

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Bloodstream Infections among Solid Organ Transplant Recipients: Eight Years’ Experience from a Turkish University Hospital

Yeşilkaya¹,

Azap²,

Demirkaya³

et al. 2013

Balkan Med J

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“…These were described by Howard et al as preservation injury [20]. We observed that aminotransferase were higher in the group that did not develop any infection, and only the need for vasopressors was higher in Group 1.…”

Section: Discussionsupporting

confidence: 61%

Infections After Liver Transplantation: A Retrospective, Single-center Study

Antunes

Teixeira

Fortuna

et al. 2015

Transplantation Proceedings

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Objective. To access the incidence of infectious problems after liver transplantation (LT).Design. A retrospective, single-center study. Materials and Methods. Patients undergoing LT from January 2008 to December 2011 were considered. Exclusion criterion was death occurring in the first 48 hours after LT. We determined the site of infection and the bacterial isolates and collected and compared recipient's variables, graft variables, surgical data, post-LT clinical data. Results. Of the 492 patients who underwent LT and the 463 considered for this study, 190 (Group 1, 41%) developed at least 1 infection, with 298 infections detected. Of these, 189 microorganisms were isolated, 81 (51%) gram-positive bacteria (most frequently Staphylococcus spp). Biliary infections were more frequent (mean time of 160.4 AE 167.7 days after LT); from 3 months after LT, gram-negative bacteria were observed (57%). Patients with infections after LT presented lower aminotransferase levels, but higher requirements in blood transfusions, intraoperative vasopressors, hemodialysis, and hospital stay. Operative and cold ischemia times were similar. Conclusion. We found a 41% incidence of all infections in a 2-year follow-up after LT. Gram-positive bacteria were more frequent isolated; however, negative bacteria were commonly isolated later. Clinical data after LT were more relevant for the development of infections. Donors' variables should be considered in future analyses.

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“…2,7,[11][12][13][14][16][17]19 We also observed that Escherichia coli (22.7%) and Klebsiella pneumoniae (9.2%) were the most common microbial agents. We found a rate of 5.8% for Acinetobacter baumannii, which reportedly shows antibiotic resistance and causes hospital infection outbreaks.…”

Section: Discussionmentioning

confidence: 59%

Untitled

Yabanoğlu

Alışkan²,

Çalışkan³

et al. 2015

Exp Clin Transplant

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Objectives: This study aimed to compare renal transplant recipients with and without infection with respect to demographic and clinical characteristics as well as risk factors; to determine the incidence of posttransplant infections; and to study the antibiotic resistance patterns of bacterial species identified as the causative organisms in posttransplant infections. Materials and Methods: This study included a total of 136 patients undergoing renal transplant in a 4-year period. The patients were categorized into 2 groups. The 2 groups were compared with each other with respect to general clinical and demographic variables and the number and frequency of infectious attacks within a 1-year follow-up, infection type, and antibiotic resistance patterns. Results: Ninety-two (67.6%) of the subjects were male and 44 (32.4%) were female. A total of 57 (41.9%) patients developed 128 infectious attacks. Urinary tract infections were the most common infections (42.1%). There was a significant correlation between a clinically relevant urinary culture proliferation and postoperative infection rate (P = .002). There was a significant correlation between antimicrobial resistance and the number of infectious attacks (P = .023). There was a significant correlation between the proliferation of Extended Spectrum Beta Lactamase-positive Enterobactericeae species and the number of infectious attacks (P = .000). Conclusions: Presence of a clinically relevant proliferation in the preoperative urinary culture, which was identified as a risk factor for infection, increased the number of infectious attacks. Moreover, Extended Spectrum Beta Lactamasepositive Enterobactericeae species increased the number of infections. These 2 principle results should be taken into account in patient management.

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Early Bacteremia After Solid Organ Transplantation

Cited by 119 publications

References 11 publications

Bloodstream Infections among Solid Organ Transplant Recipients: Eight Years’ Experience from a Turkish University Hospital

Bloodstream Infections among Solid Organ Transplant Recipients: Eight Years’ Experience from a Turkish University Hospital

Infections After Liver Transplantation: A Retrospective, Single-center Study

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