Early aggressive nutrition enhances language development in very low‐birthweight infants

Shim, So-Yeon; Ahn, Hye Mi; Cho, Su Jin; Park, Eun Ae

doi:10.1111/ped.12361

Cited by 19 publications

(14 citation statements)

References 29 publications

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“…Delayed enteral feeding and intolerance due to intestinal dysmotility increase the time to full enteral feeds and prolong the duration of intravenous nutrition, increasing the risk of infection and metabolic complications that adversely affect growth and development [72]. Enhanced energy and macronutrient intake in the first weeks after birth have also been associated with improved neurodevelopmental outcomes, including improved language scores in very low birthweight (VLBW) babies [73], increased developmental quotient in those born at <28 weeks’ gestation [74] and decreased incidence of brain lesions on MRI [75] in babies born at <30 weeks’ corrected gestational age (CGA). Emerging evidence confirms that optimising nutrition in the first few days after birth is both important [76] and safe [77] and significant efforts have been made to promote optimal long-term development by improving neonatal nutrition and reducing suboptimal growth.…”

Section: Early Nutrition Affects Morbidity and Neurodevelopmentmentioning

confidence: 99%

The Influence of Early Nutrition on Brain Growth and Neurodevelopment in Extremely Preterm Babies: A Narrative Review

et al. 2019

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Extremely preterm babies are at increased risk of less than optimal neurodevelopment compared with their term-born counterparts. Optimising nutrition is a promising avenue to mitigate the adverse neurodevelopmental consequences of preterm birth. In this narrative review, we summarize current knowledge on how nutrition, and in particular, protein intake, affects neurodevelopment in extremely preterm babies. Observational studies consistently report that higher intravenous and enteral protein intakes are associated with improved growth and possibly neurodevelopment, but differences in methodologies and combinations of intravenous and enteral nutrition strategies make it difficult to determine the effects of each intervention. Unfortunately, there are few randomized controlled trials of nutrition in this population conducted to determine neurodevelopmental outcomes. Substantial variation in reporting of trials, both of nutritional intakes and of outcomes, limits conclusions from meta-analyses. Future studies to determine the effects of nutritional intakes in extremely preterm babies need to be adequately powered to assess neurodevelopmental outcomes separately in boys and girls, and designed to address the many potential confounders which may have clouded research findings to date. The development of minimal reporting sets and core outcome sets for nutrition research will aid future meta-analyses.

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Section: Early Nutrition Affects Morbidity and Neurodevelopmentmentioning

confidence: 99%

The Influence of Early Nutrition on Brain Growth and Neurodevelopment in Extremely Preterm Babies: A Narrative Review

et al. 2019

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“…Both observational studies of early weight gain 7-10 and nutritional interventions designed to increase weight gain 11-13 document that the first weeks to months after preterm birth are particularly critical to infant brain development and function. What is less clear is the extent to which growth and nutrition later in infancy, for example after term equivalent age, influence later neurodevelopment in preterm infants.…”

mentioning

confidence: 99%

Weight Status in the First 2 Years of Life and Neurodevelopmental Impairment in Extremely Low Gestational Age Newborns

Belfort¹,

Kuban²,

O’Shea³

et al. 2016

The Journal of Pediatrics

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Objective To examine the extent to which weight gain and weight status in the first 2 years of life relate to the risk of neurodevelopmental impairment in extremely preterm infants. Study Design In a cohort of 1070 infants born between 23 and 27 weeks’ gestation, we examined weight gain from 7-28 days of life (in quartiles) and weight z-score at 12 and 24 months corrected age (in categories: <−2; ≥−2, <−1; ≥1, <1; ≥1) in relation to these adverse neurodevelopmental outcomes: Bayley-II mental development index <55, Bayley-II psychomotor development index <55, cerebral palsy, Gross Motor Function Classification System (GMFCS) ≥1 (cannot walk without assistance), microcephaly. We adjusted for confounders in logistic regression, stratified by sex, and performed separate analyses including the entire sample, and excluding children unable to walk without assistance (motor impairment). Results Weight gain in the lowest quartile from 7-28 days was not associated with higher risk of adverse outcomes. Children with a 12-month weight z-score <−2 were at increased risk for all adverse outcomes in girls, and for microcephaly and GMFCS ≥1 in boys. However, excluding children with motor impairment attenuated all associations except that of weight z-score <−2 with microcephaly in girls. Similarly, most associations of low weight z-score at 24 months with adverse outcomes were attenuated with exclusion of children with motor impairment. Conclusion Excluding children who have gross motor impairment appears to eliminate the association of low weight status with neurodevelopmental impairments at 2 years in extremely preterm infants.

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“…Early aggressive nutrition has recently been postulated as important for physical and mental development in preterm infants. 23,24 In a single-center study at a facility that used DBM, early enteral feeding that was started within 24 h after birth was associated with a decreased incidence of NEC and death. 25 In addition, in their population-based study, Kantorowska and colleagues reported that the availability of DBM was associated with positive changes, including increased breast milk feeding at NICU discharge and decreased NEC rates.…”

Section: Discussionmentioning

confidence: 99%

Feeding interval and use of donor breast milk for very low birthweight infants: A nationwide survey in Japan

Ashina

Fujioka

Totsu

et al. 2019

Pediatrics & Neonatology

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Early aggressive nutrition enhances language development in very low‐birthweight infants

Abstract: This study demonstrates the importance of the protein and energy intakes in VLBW infants in the first week of life not only for growth but also for better language development.

Cited by 19 publications

References 29 publications

The Influence of Early Nutrition on Brain Growth and Neurodevelopment in Extremely Preterm Babies: A Narrative Review

The Influence of Early Nutrition on Brain Growth and Neurodevelopment in Extremely Preterm Babies: A Narrative Review

Weight Status in the First 2 Years of Life and Neurodevelopmental Impairment in Extremely Low Gestational Age Newborns

Feeding interval and use of donor breast milk for very low birthweight infants: A nationwide survey in Japan

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