Ear Involvement in Patients with Rheumatoid Arthritis

Takatsu, Mitsuharu; Higaki, Megumu; Kinoshita, Hirotsugu; Mizushima, Yutaka; Koizuka, Izumi

doi:10.1097/01.mao.0000178138.19848.bd

Cited by 81 publications

(120 citation statements)

References 22 publications

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“…Those results are consistent with some literature data [4,9,16,17,21]. Takatsu et al detected statistical significant correlations between the degree of hearing loss and the plasma concentrations of interleukin 6 and metalloproteinase [10]. Recently, Pascual-Ramos and al showed in a prospective study, on basis of an adjusted Cox proportional model, that cumulative disease activity predicted incidental hearing impairment [18,20].…”

Section: Disscussionsupporting

confidence: 80%

“…In the same way, absence of the acoustic reflex was significantly more prevalent in RA patients compared to healthy subjects, Those results are in concordance with literature. Low frequency air conduction threshold deteriorations and air bone gap increase were also observed by different investigators [5,10,11]. Presence of worse air conduction thresholds and larger air bone gaps at lower frequencies suggest subclinical middle ear involvement [4,12].…”

Section: Disscussionmentioning

confidence: 88%

“…However, because of the small number of SNL cases, we haven't looked for relationship between methotrexate and hearing impairment in our study. The presence of a mixed type of hearing loss (10%) suggested a multifocal involvement of the audiologic system in RA [5,10,15]. The DAS disease activity score was higher in cases of RA with hypoacusia.…”

Section: Disscussionmentioning

confidence: 89%

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Relationship Between Disease Activity and Hearing Loss in Rheumatoid Arthritis Patients A Case Control Study

Rkain

Bouaddi

et al. 2016

IJMS

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Objectives: Rheumatoid arthritis (RA) is well known to affect many different organ systems. Previous work suggests that this includes the auditory system. The objectives of this work are to evaluate the pattern of hearing impairment in patients with rheumatoid arthritis and to examine the possible associations between hearing impairment and related RA features especially disease activity. Materials and methods: Thirty RA patients (mean age of 44.5 ± 9.9 years; female sex (90%)) and 17 healthy controls (mean age of 41.5±9.1 years; female sex (76.4%)) were included in our study. The 2 groups were matched for age and sex (p>0.05). Otoscopic examination was normal in all participants. No subject of the 2 groups has had any abnormalities at otoscopic examination. Hearing impairment was evaluated by pure tone audiometry and tympanometry including the static compliance, middle ear pressure, stapedial reflex threshold test. In all patients the clinical features, laboratory data, X-rays, disease activity index-DAS 28 were performed.

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Section: Disscussionsupporting

confidence: 80%

Section: Disscussionmentioning

confidence: 88%

Section: Disscussionmentioning

confidence: 89%

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Relationship Between Disease Activity and Hearing Loss in Rheumatoid Arthritis Patients A Case Control Study

Rkain

Bouaddi

et al. 2016

IJMS

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“…12 Takatsu ve ark. 13 Dış saçlı hücrelerdeki oluşabilecek değişiklikler, otoakustik emisyon test sonuçlarını etkilemektedir. Ça-lışmamızda da ilaç öncesi ve sonrası bu test yapılarak değişiklikler incelendi.…”

Section: şEkilunclassified

Effects of nonsteroidal anti-inflammatory drugs on hearing

Güçlü¹,

Ayçiçek²,

Dereköy³

et al. 2013

Turk Arch Otolaryngol

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“…Rheumatoid arthritis (RA) patients have higher frequency of HI than healthy controls (42% vs. 15.9%). 7 RA is a disease characterized by inflammation of the synovial membrane of the diarthrodial joints, which include arthrodesis of the middle ear, (incudomalleolar and incudostapedial joints) causing CHI in up to 1.9% of the cases. 4 Extra-articular involvement may also affect the auditory system targeting the inner ear, causing SNHI in 22% to 43% of the patients.…”

mentioning

confidence: 99%

Sensorineural Hearing Impairment and Subclinical Atherosclerosis in Rheumatoid Arthritis Patients Without Traditional Cardiovascular Risk Factors

et al. 2016

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Objectives: This study aims to evaluate the association of hearing impairment with carotid intima-media thickness and subclinical atherosclerosis in rheumatoid arthritis (RA) patients. Patients and methods: A total of 41 RA patients (2 males, 39 females; mean age 46.5±10.2 years; range 20 to 63 years) with no known traditional cardiovascular risk factors were included. Routine clinical and laboratory assessments for RA patients were performed. Pure tone air (250-8000 Hz) and bone conduction (250-6000 Hz) thresholds were obtained, tympanograms and impedance audiometry were conducted. Sensorineural hearing impairment was defined if the average thresholds were ≥25 decibels. Carotid intima-media thickness was assessed and classified with a cut-off point of 0.6 mm. Results: Thirteen patients (31.7%) had normal audition, while 28 (68.3%) had hearing impairment. Of these, 22 had bilateral sensorineural hearing impairment. Four patients had conductive hearing impairment (right in three patients and left in one patient). Patients with sensorineural hearing impairment had increased carotid intima-media thickness in the media segment of carotid common artery compared to patients with normal hearing (right ear p=0.007; left ear p=0.075). Thickening of the carotid intima-media thickness was associated with sensorineural hearing impairment in RA patients. Conclusion: Rheumatoid arthritis patients should be evaluated by carotid intima-media thickness as a possible contributing factor of hearing impairment in patients without cardiovascular risk factors.

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Ear Involvement in Patients with Rheumatoid Arthritis

Abstract: We demonstrated that there is increased SNHL in patients with RA, which may result from systemic inflammation and tissue injury, and increased latent-type CHL caused by stiffness of the middle ear system whose mechanisms are not yet clear.

Cited by 81 publications

References 22 publications

Relationship Between Disease Activity and Hearing Loss in Rheumatoid Arthritis Patients A Case Control Study

Relationship Between Disease Activity and Hearing Loss in Rheumatoid Arthritis Patients A Case Control Study

Effects of nonsteroidal anti-inflammatory drugs on hearing

Sensorineural Hearing Impairment and Subclinical Atherosclerosis in Rheumatoid Arthritis Patients Without Traditional Cardiovascular Risk Factors

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