Relationship Between Disease Activity and Hearing Loss in Rheumatoid Arthritis Patients A Case Control Study

Rkain, I; Rkain, Hanan; Bouaddi, I.; Dakka, Taoufik; Hajjaj–Hassouni, N.; Essakalli, Leila

doi:10.15342/ijms.v3i1.86

Cited by 4 publications

(6 citation statements)

References 18 publications

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“…The study showed that RA patients had nearly doubled probability of developing a hearing impairment than those without RA. Furthermore, they confirmed that hearing loss risk is related to RA rising with age [11], while Rkain et al [16] found that HL was more prevalent in patients with RA compared to healthy groups. Among RA patients 43.4% had conductive hearing loss, 3.3% sensorineural, and 10% mixed hearing loss.…”

Section: Introductionmentioning

confidence: 83%

A study on the association of cervical spondylosis severity, as indicated by cervical motions, with hearing impairment

Karam

Hasan

Saeed

2021

Biomedical Human Kinetics

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Study aim: The present study investigates the possible relation between the limitation of cervical motion in a patient with cervical spondylosis and hearing impairment. Material and methods: Cross-sectional research was performed based on 60 participants suffering from cervical spondylosis (CS) selected from an orthopaedic and physiotherapy department. The data collection techniques included questionnaire, electronic tools, measurements with a mechanical device including measuring the cervical range of motion (ROM) by goniometer, and physical examination including pure tone audiometry (PTA) and tympanogram. Results: Right rotation was the most common limitation, which affected 43 patients, followed by left rotation limitation, which was recorded in 40 patients. The extension, left lateral flexion, flexion, and right lateral flexion limitation showed less effect. Conclusions: Left rotation limitation was found to be an independent predictor of hearing impairment especially in men. Age was also a risk factor for sensory neural hearing loss (SNHL). These findings are important in the facilitation of investigating SNHL in cervical spondylosis patients.

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Section: Introductionmentioning

confidence: 83%

A study on the association of cervical spondylosis severity, as indicated by cervical motions, with hearing impairment

Karam

Hasan

Saeed

2021

Biomedical Human Kinetics

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“…Ototoxic drugs which were taken by the child may have caused inner ear damage that lead to sensory neural component of hearing loss. The presence of a mixed type of hearing loss suggested a multifocal involvement of the audiological system in RA [5].…”

Section: /4mentioning

confidence: 96%

“…Conductive hearing loss in RA may be related either to stiffness or to discontinuity of the ossicles in the middle ear [5]. Since the child was under immunosuppressants, she is vulnerable for infections leading to recurrent ear infection.…”

Section: /4mentioning

confidence: 99%

“…Evaluation of audiometric test should be integrated in RA assessment to detect and manage possible hearing impairment caused by the disease itself and/or by therapeutic intervention. Furthermore, patients must be informed by their physician of the risk of having auditory damage as a complication of the disease [5].…”

Section: /4mentioning

confidence: 99%

“…Rheumatoid Arthritis (RA) is an inflammatory disease of multi factorial origin, including genetic predisposition and characterized by immune -driven, chronic inflammation [1,2]. Juvenile Idiopathic Arthritis (JIA) has some definite differences from RA in terms of genetic heterogeneity, phenotypically diverse presentations such as systemic type, polyarthritis, or oligoarthritis, however, both of them share the common pathogenic mechanisms [3][4][5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

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Hearing Loss in Systemic Onset Juvenile Idiopathic Arthritis (Sojia) -A Single Case Study

2024

JSM Pediatr Surg

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Juvenile Rheumatoid Arthritis is a common type of arthritis in children under the age of sixteen. Females are more affected than males with ratio of 2:1. Systemic onset Juvenile Idiopathic Arthritis (SoJIA) is an immune driven inflammatory condition that develops in children. Although SoJIA can occur any time during childhood it usually starts before age five. Inflammation of internal organs and MAS (macrophage activation syndrome) is closely associated with SoJIA. Children with SoJIA have high levels of two powerful inflammatory protein (cytokines) called Interleukin -1 and Interleukin-6. The management of SoJIA follows up with NSAIDs, Corticosteroids, DMARDs and inflammatory cytokine blockade. The incudomalleolar and incudostapedial joint are synovial in nature and hence could be involved in inflammatory process. Immune complex mediated vasculitis and ototoxic side effects may cause a pathological inner ear. Thus individuals with SoJIA are at higher risk of hearing impairment.

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Review: Failure of current digoxin monitoring for toxicity: new monitoring recommendations to maintain therapeutic levels for efficacy

Gona,

Rosenberg,

Fyffe-Freil

et al. 2023

Front. Cardiovasc. Med.

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The current recommendations for monitoring digoxin, a narrow therapeutic index drug, are limited to confirming medication use or investigating suspicion of toxicity and fail our oath to do no harm. Numerous meta-analyses evaluating digoxin use consistently recommend frequent monitoring to maintain the level of 0.5 to ≤1.0 ng/ml because higher levels lead to increased morbidity and mortality without benefit. Data from the United States National Poison Control Center (2012–2020) show annual deaths due to digoxin of 18–36 compared to lithium's 1–7, and warfarin's 0–2 respectively. The latter drugs also have narrow therapeutic indexes like digoxin yet are more carefully monitored. Recognition of digoxin toxicity is impaired as levels are not being routinely checked after medications are added to a patient's regimen. In addition, providers may be using ranges to guide treatment that are no longer appropriate. It is imperative that monitoring guidelines and laboratory therapeutic levels are revised to reduce morbidity and mortality due to digoxin. In this review, we provide a comprehensive literature review of digoxin monitoring guidelines, digoxin toxicity, and evidence to support revising the ranges for serum digoxin monitoring.

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Relationship Between Disease Activity and Hearing Loss in Rheumatoid Arthritis Patients A Case Control Study

Cited by 4 publications

References 18 publications

A study on the association of cervical spondylosis severity, as indicated by cervical motions, with hearing impairment

A study on the association of cervical spondylosis severity, as indicated by cervical motions, with hearing impairment

Hearing Loss in Systemic Onset Juvenile Idiopathic Arthritis (Sojia) -A Single Case Study

Review: Failure of current digoxin monitoring for toxicity: new monitoring recommendations to maintain therapeutic levels for efficacy

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