E2F7 Transcriptionally Inhibits MicroRNA-199b Expression to Promote USP47, Thereby Enhancing Colon Cancer Tumor Stem Cell Activity and Promoting the Occurrence of Colon Cancer

Guo, Xiong; Liu, Ling; Zhang, Qi; Yang, Weiming; Zhang, Yang

doi:10.3389/fonc.2020.565449

Cited by 17 publications

(16 citation statements)

References 30 publications

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“… 106 , 107 One promising miRNA, miR-4711-5p, can inhibit CSC properties by downregulating Kruppel-like factor 5 expression and MDM2. 24 Similarly, the E2F7-regulated miR-199b/USP47/MAPK axis promotes the stemness of colon CSCs 49 (see Figure 1 ).…”

Section: Immune Microenvironment and E2fs In Crcmentioning

confidence: 94%

“… 48 Similarly, E2F7 suppresses miR-199b expression in SW403 cells, and miR-199b targets ubiquitin-specific protease 47 (USP47) that stabilizes MAPK, promoting colon cancer stem cell activity and subsequently accelerating colon cancer progression. 49 Furthermore, Gao et al summarized the bidirectional cross-link between E2F3 and 29 miRNAs in human cancers and elucidated how this regulation occurs. 27 This review unfolds a series of RNA interaction profiles (see Figure 1 ).…”

Section: E2f-related Rnas In Crcmentioning

confidence: 99%

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An Update on the Potential Roles of E2F Family Members in Colorectal Cancer

Xu¹,

Qu²,

Ren³

et al. 2021

CMAR

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Colorectal cancer (CRC) is a major health burden worldwide, and thus, optimised diagnosis and treatments are imperative. E2F transcription factors (E2Fs) are a family of transcription factors consisting of eight genes, contributing to the oncogenesis and development of CRC. Importantly, E2Fs control not only the cell cycle but also apoptosis, senescence, DNA damage response, and drug resistance by interacting with multiple signaling pathways. However, the specific functions and intricate machinery of these eight E2Fs in human CRC remain unclear in many respects. Evidence on E2Fs and CRC has been scattered on the related regulatory genes, microRNAs (miRNAs), and competing endogenous RNAs (ceRNAs). Accordingly, some drugs targeting E2Fs have been transferred from preclinical to clinical application. Herein, we have systemically reviewed the current literature on the roles of various E2Fs in CRC with the purpose of providing possible clinical implications for patient diagnosis and prognosis and future treatment strategy design, thereby furthering the understanding of the E2Fs.

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Section: Immune Microenvironment and E2fs In Crcmentioning

confidence: 94%

Section: E2f-related Rnas In Crcmentioning

confidence: 99%

An Update on the Potential Roles of E2F Family Members in Colorectal Cancer

Xu¹,

Qu²,

Ren³

et al. 2021

CMAR

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“…Upregulation of E2F6 mRNA expression, in turn, was found to upregulate the stemness marker c-Kit through E2F6-mediated silencing of miR‐193a and to promote ovarian cancer stemness and tumorigenesis ( 22 , 128 ). In colon CSCs, E2F7 was found to transcriptionally inhibit miR-199b expression to promote USP47 expression, thereby increasing colon CSC stemness and accelerating the occurrence of colon cancer ( 23 ). In addition, E2F7 silencing was shown to decrease the production of ALDH1 + cells and repress antagonistic effects of ALDH1 + cells on 5-fluorouracil (5-FU) treatment.…”

Section: Role Of E2fs In the Biological Behaviors Of Cancer Stem Cellsmentioning

confidence: 99%

“…E2F3 is epigenetically regulated and might be a potential therapeutic target ( 139 , 140 ). In addition, E2F7 is highly expressed in HCC and colon cancer and can promote stemness in these cancers, suggesting that E2F7 may be a novel therapeutic target for HCC and colon cancer ( 23 , 26 ). There are few studies on other E2F family members (E2F4, E2F5, E2F6, E2F8) in CSCs, but these E2Fs also have diagnostic and prognostic value and are therapeutic targets in different cancers.…”

Section: E2fs Are Novel Biomarkers and Therapeutic Targets Associated With Cscsmentioning

confidence: 99%

“…In cancer literature, the role of E2Fs in CSCs is widely regarded as an activator gene. Up-regulation of E2Fs is reported to be involved in proliferation promotion ( 21 ), maintenance and acquisition of self-renewal ( 22 , 23 ), invasion and metastatic progression ( 24 ) and resistance to chemotherapy and radiotherapy ( 25 ) in many CSCs. However, the unexpected positive effect of repressive E2Fs on stem cell attributes of CSCs could potentially be a consequence of repression of negative regulators such as miRNAs ( 26 ).…”

Section: Introductionmentioning

confidence: 99%

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Emerging Role of E2F Family in Cancer Stem Cells

Xie

Qin

et al. 2021

Front. Oncol.

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The E2F family of transcription factors (E2Fs) consist of eight genes in mammals. These genes encode ten proteins that are usually classified as transcriptional activators or transcriptional repressors. E2Fs are important for many cellular processes, from their canonical role in cell cycle regulation to other roles in angiogenesis, the DNA damage response and apoptosis. A growing body of evidence demonstrates that cancer stem cells (CSCs) are key players in tumor development, metastasis, drug resistance and recurrence. This review focuses on the role of E2Fs in CSCs and notes that many signals can regulate the activities of E2Fs, which in turn can transcriptionally regulate many different targets to contribute to various biological characteristics of CSCs, such as proliferation, self-renewal, metastasis, and drug resistance. Therefore, E2Fs may be promising biomarkers and therapeutic targets associated with CSCs pathologies. Finally, exploring therapeutic strategies for E2Fs may result in disruption of CSCs, which may prevent tumor growth, metastasis, and drug resistance.

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