E2F7 enhances hepatocellular carcinoma growth by preserving the SP1/SOX4/Anillin axis via repressing miRNA‐383‐5p transcription

Hao, Fang; Wang, Nan; Zhang, Yifan; Xu, Wen; Chen, Yongjun; Fei, Xiaochun; Wang, Junqing

doi:10.1002/mc.23454

Cited by 5 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Its activation maintains genome ploidy in hepatocytes and has also been seen in a variety of human cancers 18,19 . Recently, we verified that E2F7 was extremely over‐expressed in HCC, associating with unsatisfactory parameters of HCC including larger tumor dimensions, advanced tumor stages, and shortened survival period 20 . Besides, Anillin, a key actin‐binding protein, is also highly up‐regulated by E2F7 via SP1/SOX4/Anillin pathway in HCC 21 .…”

Section: Introductionmentioning

confidence: 64%

“…E2F7 is involved in the cell cycle, mainly serving a repressive transcriptional function 17,18 . Recently, we verified that E2F7 was extremely over‐expressed in HCC, and positively associated with unsatisfactory parameters of HCC, like larger tumor dimensions, advanced tumor stages, and shortened survival period 20 . Anillin is a key actin‐binding protein regulating cell cycles, promoting cytokinesis and tumor growth 22 .…”

Section: Discussionmentioning

confidence: 93%

“…17,18 Recently, we verified that E2F7 was extremely over-expressed in HCC, and positively associated with unsatisfactory parameters of HCC, like larger tumor dimensions, advanced tumor stages, and shortened survival period. 20 Anillin is a key actin-binding protein regulating cell cycles, promoting cytokinesis and tumor growth. 22 As we illustrated recently, Anillin is highly expressed in HCC as a promotor of tumorigenesis and significantly positively correlated with the anomalous up-regulation of E2F7 as a terminal downstream regulator of E2F7 in the HCC process.…”

Section: Discussionmentioning

confidence: 99%

“…18,19 Recently, we verified that E2F7 was extremely over-expressed in HCC, associating with unsatisfactory parameters of HCC including larger tumor dimensions, advanced tumor stages, and shortened survival period. 20 Besides, Anillin, a key actin-binding protein, is also highly up-regulated by E2F7 via SP1/SOX4/Anillin pathway in HCC. 21 Anillin is reported to promote cytokinesis and tumor growth in HCC.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Attenuation of binuclear hepatocytes in the paracancerous liver tissue is associated with short‐term recurrence of hepatocellular carcinoma post‐radical surgery

Zhang,

Wang,

Hao

et al. 2023

The FASEB Journal

Self Cite

View full text Add to dashboard Cite

Short‐term recurrence of hepatocellular carcinoma (HCC) after radical resection leads to dismal outcomes. To screen high‐recurrence risk patients to provide adjuvant treatment is necessary. Herein, based on our previous research, we further focused on the changes in the abundance of binuclear hepatocytes (ABH) in the paracancerous liver tissue to discuss the relationship between the attenuation of binuclear hepatocytes and postoperative short‐term recurrence, by combining with the assessment of the value of a reported independent early recurrence risk factor in HCC, protein induced by vitamin K absence or antagonist‐II (PIVKA‐II). A cohort of 142 paracancerous liver tissues from HCC patients who received radical resection was collected. Binuclear hepatocytes were reduced in the paracancerous liver tissues, compared with the liver tissues from normal donors. ABH was negatively correlated with clinical features such as tumor size, TNM stages, tumor microsatellite formation, venous invasion, and Alpha‐fetoprotein (AFP) level, as well as the expression of E2F7 and Anillin, which are two critical regulators concerning the hepatocyte polyploidization. According to the short‐term recurrence information, ABH value was laminated, and univariate and multivariate logistic regression was performed to analyze the relationship between paracancerous ABH and short‐term tumor relapse. Simultaneously, the predictive effectiveness of the ABH value was compared with the preoperative PIVKA‐II value. As observed, the paracancerous ABH value below 1.5% was found to be an independent risk factor for recurrence. In conclusion, the paracancerous ABH is a credible indicator of short‐term recurrence of HCC patients after radical resection, and regular assessment of ABH might help to prevent short‐term HCC recurrence.

show abstract

Section: Introductionmentioning

confidence: 64%