Dyssynchronous ventricular contraction in Wolff–Parkinson–White syndrome: a risk factor for the development of dilated cardiomyopathy

Abstract

A causal relationship between overt ventricular preexcitation and the development of DCM is supported by the complete recovery of LV function and reversed LV remodeling after the loss of ventricular preexcitation. Preexcitation-related dyssynchrony was probably the crucial mechanism. Not only right-sided septal or paraseptal but also free wall overt APs may induce LV dysfunction and even DCM. AP-induced DCM is an indication for ablation with a good prognosis.

The impact of left ventricular deformation and dyssynchrony on improvement of left ventricular ejection fraction following radiofrequency catheter ablation in Wolff‐Parkinson‐White syndrome: A comprehensive study by speckle tracking echocardiography

“…In our study, of 30 patients with WPW syndrome, 11 (37%) had regional wall‐motion abnormalities observed as DWM. APs of these patients with DWM were frequently located at the septum (7/11, 64%), which was consistent with the findings of previous studies . However, DWM did not have significant predictive value for a favorable RFCA outcome in our patients, while the baseline dyssynchrony index did.…”

“…demonstrated regional wall‐motion impairment, which was possibly indicative of “DWM” in the left posterior wall corresponding to a left posteroseptal AP location, along with recovery following RFCA using 2‐dimensional echocardiography. Other investigators later reported similar observation in WPW syndrome patients with septal AP . In our study, of 30 patients with WPW syndrome, 11 (37%) had regional wall‐motion abnormalities observed as DWM.…”

“…Currently, only a limited number of studies have investigated LV function relating to RFCA using both conventional echocardiography and STE in patients with WPW syndrome . A summary of these published clinical studies is represented in Table .…”

“…The beneficial effects of RFCA on LV function in WPW syndrome have been reported by several investigators . However, only a few studies have performed systematic STE analysis in WPW syndrome cases or investigated the effect of the presence of DWM .…”

Risk Factors for Death or Heart Transplant for Patients with Right Ventricular Dysfunction After the Norwood Procedure: A Secondary Analysis of the Single Ventricle Reconstruction Trial

“…As the intraventricular pressure rises in systole, the thinned scar myocardium will dilate outward, called dyskinesia. These are all the forms of mechanical dyssynchrony, defined as an abnormal myocardial contractile motion, which has been shown to cause progressive ventricular dysfunction overtime (Dai et al 2013;Lancellotti & Moonen 2012). Therefore, the late worsening of function in the RVPA cohort might represents a progressive influence of the myocardial scar on ventricular function due to the associated mechanical dyssynchrony.…”