Dysregulation of subcutaneous adipose tissue blood flow in overweight postmenopausal women

Andersson, Jonas; Sjöström, L; Karlsson, Marcus; Wiklund, Urban; Hultin, Magnus; Karpe, Fredrik; Olsson, Tommy

doi:10.1097/gme.0b013e3181c12b26

Cited by 17 publications

(13 citation statements)

References 33 publications

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“…Anthropometric data were reported previously for this cohort. 10 Notably, both post-menopausal normal-weight and post-menopausal obese women had an approximately twofold larger intra-abdominal AT area compared with their pre-menopausal counterparts, despite similar BMI. The postmenopausal obese group had higher levels of glucose (AUC) and free fatty acids (AUC) compared with the pre-menopausal groups.…”

Section: Basal Characteristicsmentioning

confidence: 99%

“…10 Briefly, we recruited 43 healthy women and divided them into four groups: normal-weight (n ¼ 11) and obese (n ¼ 11) pre-menopausal women, and normal-weight (n ¼ 10) and obese (n ¼ 11) post-menopausal women. Postmenopausal status was defined as the lack of menstrual periods for at least 12 continuous months.…”

Section: Subjectsmentioning

confidence: 99%

“…Baseline anthropometry (weight, waist, hip and blood pressure) was measured and an oral glucose tolerance test was performed as previously described. 10 A computed tomography scan was performed on a separate day, within a month from the other measurements. ATBF ATBF was measured by 133 Xe washout.…”

Section: Clinical Protocolmentioning

confidence: 99%

“…2,[11][12][13] With menopause, women change their fat distribution to a more central (android) location. 17 On the basis of the metabolic differences between subcutaneous and visceral fat, and our recent demonstration of dysregulation of ABTF in post-menopausal overweight women, 10 we hypothesised that ATBF is closely related to the size of the abdominal fat depot. We also hypothesised that adipokines are potential independent regulators of ATBF.…”

Section: Introductionmentioning

confidence: 99%

“…10 Putative modulators of a link between obesity, ATBF, nitric oxide activity and autonomic activity include the adipokines leptin and adiponectin, which are secreted into the peripheral circulation from AT. 2,[11][12][13] These adipokines predict risk for type 2 diabetes and cardiovascular disease, [14][15][16] and in vitro studies have demonstrated the nitric oxide-mediated vasorelaxation effects of both leptin and adiponectin.…”

Section: Introductionmentioning

confidence: 99%

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Association of adipose tissue blood flow with fat depot sizes and adipokines in women

et al. 2011

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Objective: To explore possible associations between adipose tissue (AT) blood flow (ATBF), AT depot sizes and adipocytederived hormones (adipokines) in women. Subjects: In all, 43 healthy women were divided into four groups: normal-weight (n ¼ 11) and obese (n ¼ 11) pre-menopausal women and normal-weight (n ¼ 10) and obese (n ¼ 11) post-menopausal women. Methods: Fasting levels of adipokines were obtained, and a single-slice computed tomography scan at the level of L4-L5 was used to estimate fat depot sizes. ATBF was assessed by xenon washout while in a fasting state and after oral glucose load. We also measured glucose, insulin and non-esterified fatty acids. Results: Total, subcutaneous and visceral AT areas strongly correlated with ATBF (all Po0.001). Circulating leptin levels strongly and inversely correlated with ATBF (P ¼ 0.001), but this association did not remain after adjustment for body mass index. Adiponectin was not associated with blood flow. Conclusion: ATBF is closely linked to subcutaneous and visceral AT size. Further analyses are needed to determine possible mediators of this association, including mechanistic studies to assess a putative role for leptin as a significant modulator of blood flow.

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Section: Basal Characteristicsmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

Section: Clinical Protocolmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of adipose tissue blood flow with fat depot sizes and adipokines in women

et al. 2011

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Serum asymmetric dimethylarginine and nitric oxide levels in obese postmenopausal women

Koçak¹,

Öner-İyidoğan²,

Gürdöl³

et al. 2011

J. Clin. Lab. Anal.

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Obesity impairs vasodilatation and blood flow increase mediated by endothelial nitric oxide: An overview

Toda

Okamura

2013

The Journal of Clinical Pharmacology

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Obesity dramatically increases the risk of development of cardiovascular and metabolic diseases. Endothelial dysfunction induced by obesity is an important risk factor that impairs blood flow controls in various organs. Impaired endothelial function occurs early in life in obese children. Obesity-induced endothelial dysfunction is associated with decreased nitric oxide (NO) production due to impaired endothelial NO synthase activity and expression and increased production of superoxide anion and the endogenous NOS inhibitor ADMA, together with increased vasoconstrictor factors, such as endothelin-1 and sympathetic nerve activation. Decreased endothelial progenitor cells are also involved in endothelial cell senescence in obese individuals. Insulin resistance and diabetes mellitus augment obesity-induced endothelial dysfunction. Adipokines liberated from adipose tissues play roles in modulating endothelial function; adiponectin and ghrelin have beneficial effects on endothelial cells. Effects of leptin on endothelial function are controversial. Decreased body weight by physical exercise, dietary interventions, and bariatric surgery are effective measures that reverse endothelial dysfunction; however, the weight control is not only the reason for improving of endothelia function. Pharmacological therapies with β-adrenoceptor antagonists, resveratolol, anti-obesity agents, nifedipine, and NADPH oxidase inhibitors may also be effective; however, these treatments have to be utilized under the basis of exercise and dietary controls.

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Dysregulation of subcutaneous adipose tissue blood flow in overweight postmenopausal women

Abstract: Loss of ATBF flexibility in overweight postmenopausal women may contribute to the metabolic dysfunction seen in this group of women.

Cited by 17 publications

References 33 publications

Association of adipose tissue blood flow with fat depot sizes and adipokines in women

Association of adipose tissue blood flow with fat depot sizes and adipokines in women

Serum asymmetric dimethylarginine and nitric oxide levels in obese postmenopausal women

Obesity impairs vasodilatation and blood flow increase mediated by endothelial nitric oxide: An overview

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