Dyslipidemia in Type 2 Diabetes mellitus

Thapa, Subarna Dhoj; K.C, Shiva Raj; Gautam, Santosh; Gyawali, Deepika

doi:10.3126/jpn.v7i2.17978

Cited by 25 publications

(24 citation statements)

References 15 publications

(18 reference statements)

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“…Among the lipid parameters, isolated hypertriglyceridemia was the most common in T2DM patients. Similar findings were reported by other studies as well [25,[35][36][37][38].…”

Section: Discussionsupporting

confidence: 93%

Dyslipidemic profile in Type 2 Diabetes Mellitus: A hospital-based study from Eastern Nepal

et al. 2020

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Background: Dyslipidemia is highly prevalent in Type 2 Diabetes Mellitus (T2DM). It plays a major role in the pathogenesis for diabetic complications. This study intends to exemplify the pattern of dyslipidemia prevalent in T2DM patients attending tertiary care centre of Eastern Nepal. Material and methods: This is a hospital based cross-sectional study conducted in the T2DM patients visiting the routine biochemistry laboratory for their routine blood investigations. 226 patients were included who fulfilled the inclusion criteria. Biochemical parameters were analyzed in routine biochemistry laboratory in cobas c311 autoanalyzer. Results: Out of the 226 T2DM patients, 51% were female and 49% were male respectively. The mean age group was 54.15 ± 12.62 years. Mean value of, HbA1c level, total cholesterol, TG, HDL and LDL was 8.16 ± 2.59 %, 289.04 ± 47.83, 297.77 ± 119.64, 35.62 ± 12.64 140.88 ± 40.58 respectively. HbA1c was significantly correlated with the lipid profile in T2DM patients (p < 0.05). Conclusion: The findings from the present study depicts that the prevalence of dyslipidemia is higher in T2DM in our centre with hypertriglyceridemia being the major type of dyslipidemia in these patients. In addition, male exhibited higher rate of dyslipidemia compare to their female counterparts respectively.

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“…Among the lipid parameters, isolated hypertriglyceridemia was the most common in T2DM patients. Similar findings were reported by other studies as well [25,[35][36][37][38].…”

Section: Discussionsupporting

confidence: 93%

Dyslipidemic profile in Type 2 Diabetes Mellitus: A hospital-based study from Eastern Nepal

et al. 2020

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“…28 The prevalence of high LDL-C obtained in this study was (28.6%), which was consistent with a study conducted in China (28%), 25 but lower than the study conducted in Kembata, Ethiopia (43.8%), 19 Hawwassa, Ethiopia (34.9%) 8 and Nepal (73.8%). 22 The arise in LDL-C particle in T2DM patients might be due to lipolysis of very-low -density lipoprotein (VLDL) which after triglyceride supplementation by cholesteryl ester transfer protein, along with hepatic lipase mediated hydrolysis of triglyceride and phospholipids which leads to increased production of LDL-C. 13 Our study showed a lower prevalence of low HDL-C compared to reports from Ethiopia (41.9-68.7%) 19,26 and Nepal (64%), 27 whereas higher than reports from Hawassa, Ethiopia. 8 In the current study both serum, TC, and TG showed a significant positive correlation with fasting blood levels and hypertension in T2DM patients.…”

Section: Discussionmentioning

confidence: 46%

“…The findings of this study are similar to a study conducted in Egypt (47%) 26 but lower than a study conducted in Nepal (53.77%). 27 The difference in the pattern of dyslipidemia reported in T2DM patients might be due to differing cut points in some studies, cultural factors, and lifestyle of the population.…”

Section: Discussionmentioning

confidence: 99%

<p>Dyslipidemia and Its Associated Risk Factors Among Adult Type-2 Diabetic Patients at Jimma University Medical Center, Jimma, Southwest Ethiopia</p>

Haile¹,

Timerga²

2020

DMSO

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Background: Dyslipidemia is one of the major modifiable risk factors for cardiovascular diseases (CVD) in a type-2 diabetic (T2DM) patient. Dyslipidemia in T2DM patients is attributed due to increased free fatty acid flux secondary to insulin resistance. Despite its high prevalence and related complication of dyslipidemia in T2DM patients, there is a paucity of data on the prevalence of dyslipidemia in T2DM patients in Ethiopia. Objective: To determine the prevalence of dyslipidemia and its associated risk factors among T2DM patients at Jimma medical center (JUMC) Jimma, Ethiopia. Methods and Materials: An institution-based-cross-sectional study was conducted from June 1 to August 4, 2019. A convenience sampling technique was used to recruit 248 T2DM patients in the study. Data on socio-demographic characteristics, behavioral, and clinical factors were collected using a structured questionnaire through face to face interviews. Five milliliters of the fasting venous blood sample was collected for serum glucose and lipid profile analysis. Blood pressure, weight, and height were measured. Data were analyzed by SPSS version 21. Bivariate and multivariate logistic regression analyses were performed and p-value <0.05 was considered as statistically significant. Results: The overall prevalence of dyslipidemia among study participants was 68.1%. Isolated lipid profile abnormality of hypertriglyceridemia was found in 48%, hypercholesterolemia in 13.7%, high level of low-density lipoprotein (LDL-C) in 28.6%, and low level of high-density lipoprotein (HDL-C) in 50.8% study participants. Being in an age group ≥30 years, physical inactivity, being obese, hypertension, and high blood glucose value were significantly associated factors with dyslipidemia. Conclusion: High prevalence of dyslipidemia was found among T2DM in the study area. The findings of this study should be taken into account to conduct appropriate intervention measures on the identified risk factor, and implement routine screening, treatments, and prevention of dyslipidemia.

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“…Hypercholesterolemia and hypertriglyceridemia secondary to Type 2 diabetes mellitus [[64], [65], [66]] and hypothyroidism [67] have been reported. Xanthelasma palpebrarum with hypercholesterolemia has been reported in eleven people in a study of lipid profile of patients with xanthelasma palpebrarum [68] A case of a 45 year old hypertensive male with large multiple tuberous xanthomas, hypercholesterolemia, hypertriglyceridemia and high LDL cholesterol has been reported [69].…”

Section: Resultsmentioning

confidence: 99%

Case reports of metabolic disorders from Nepal

Pandey

2019

Molecular Genetics and Metabolism Reports

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BackgroundThe prevalence of metabolic disease in Nepal is largely unknown. Some consideration has been given by the nepalese government for high prevalence of congenital disorders in some populations, but disorders due to enzymatic deficiencies have not been considered as a class of diseases where timely diagnosis and intervention might be possible. No case for these disorders has been made so far, however, findings of many rare metabolic diseases have been reported in literature by the nepalese medical fraternity.MethodsA search for case reports on metabolic disorders listed according to International Classification of Diseases −11 was performed using the google search engine.ResultsA total of 443 cases have been discovered presented in the literature. This does not include disorders that might be due to lifestyle and behaviour. Most of the reported cases have been identified based on clinical acumen, radiological and histopathological findings.ConclusionsGlucose 6 phosphate dehydrogenase deficiency, Wilson's disease and lysosomal disorders should be considered for early diagnosis through newborn screening along with the acknowledged disorders hypothyroidism and hemoglobinopathies in Nepal. Early intervention in these disorders can significantly reduce morbidity and mortality in infancy.

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Dyslipidemia in Type 2 Diabetes mellitus

Cited by 25 publications

References 15 publications

Dyslipidemic profile in Type 2 Diabetes Mellitus: A hospital-based study from Eastern Nepal

Dyslipidemic profile in Type 2 Diabetes Mellitus: A hospital-based study from Eastern Nepal

<p>Dyslipidemia and Its Associated Risk Factors Among Adult Type-2 Diabetic Patients at Jimma University Medical Center, Jimma, Southwest Ethiopia</p>

Case reports of metabolic disorders from Nepal

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