Dyslipidemic profile in Type 2 Diabetes Mellitus: A hospital-based study from Eastern Nepal

Abstract

Background: Dyslipidemia is highly prevalent in Type 2 Diabetes Mellitus (T2DM). It plays a major role in the pathogenesis for diabetic complications. This study intends to exemplify the pattern of dyslipidemia prevalent in T2DM patients attending tertiary care centre of Eastern Nepal.
 Material and methods: This is a hospital based cross-sectional study conducted in the T2DM patients visiting the routine biochemistry laboratory for their routine blood investigations. 226 patients were included who fulfilled the inclusion criteria. Biochemical parameters were analyzed in routine biochemistry laboratory in cobas c311 autoanalyzer.
 Results: Out of the 226 T2DM patients, 51% were female and 49% were male respectively. The mean age group was 54.15 ± 12.62 years. Mean value of, HbA1c level, total cholesterol, TG, HDL and LDL was 8.16 ± 2.59 %, 289.04 ± 47.83, 297.77 ± 119.64, 35.62 ± 12.64 140.88 ± 40.58 respectively. HbA1c was significantly correlated with the lipid profile in T2DM patients (p < 0.05).
 Conclusion: The findings from the present study depicts that the prevalence of dyslipidemia is higher in T2DM in our centre with hypertriglyceridemia being the major type of dyslipidemia in these patients. In addition, male exhibited higher rate of dyslipidemia compare to their female counterparts respectively.

Dyslipidemia in Patients with Type 2 Diabetes Mellitus in a Tertiary Care Centre: A Descriptive Cross-sectional Study

“…There was high prevalence of dyslipidemia in patients with diabetes (63.1%) which is similar to study done by Das et al 11 However this was slight lower than other study reported from other part of the country. 12 Our study demonstrated higher prevalence of dyslipidemia among male than female i.e.…”

“…9 Changes in lifestyle such as consumption of western style diets which include high calorie foods with increased carbohydrate, fat, and red meat consumption and low fiber diet have contributed to the increased prevalence of obesity, metabolic syndrome and T2DM. 10 There was high prevalence of dyslipidemia in patients with diabetes (63.1%) which is similar to study done by Das et al 11 However this was slight lower than other study reported from other part of the country. 12 Our study demonstrated higher prevalence of dyslipidemia among male than female i.e.…”

“…69.4% and 54.1% respectively which is comparable to similar study done at tertiary center in this region. 11 When focusing on the subtypes of dyslipidemia, most prevalent was high LDL (94.2%) followed by mixed dyslipidemia (91.1%), high total cholesterol (82.1%), hypertriglyceridemia (73.7%) and low HDL (46.9%). High LDL was most prevalent dyslipidemia in both male and female which was 65.1% and 51.4% respectively.…”

Apolipoprotein E Gene Variation in Pakistani Type 2 Diabetic Subjects with and without Cardiovascular Complications

“…High levels (>150 mg/dL) of Triglycerides were observed in both genders as compared to healthy controls. These observations were similar to the study carried out by (Mehta et al, 2021) in Eastern Nepal and (Das et al, 2020). In the present study deranged lipid profile due to atherosclerosis was found in majority of the patients which could be due to decreased insulin sensitivity enhanced by hyperglycemia and toxicity due to lipid accumulation.…”