Dynamics of the level of middle molecules and activity of some enzymes of neurotransmitter metabolism in patients with resistant endogenous psychosis under plasmapheresis

Aspects of metabolic changes in first-episode drug-naïve schizophrenic patients

“…At the same time, it has been shown that in chronic schizophrenic patients the platelet MAO activity was lower than in controls (26,27). In our investigations, we found a significant increase of platelet MAO activity both in chronic schizophrenic (9,28,29) and FES patients.…”

“…Our findings (4) that in FES patients MMEM concentration was elevated more than twofold support this thesis. It is postulated that, during the development of the mental disorders, there is an activation of catabolic processes that increase the concentration of different MMEM components (9,29,39). Many components of MMEM fraction possess neurotoxic properties and inhibit different metabolic and physiological processes (40–42).…”

Biochemical profile in patients with anxious depression under the treatment with serotonergic antidepressants with different mechanisms of action

“…The finding that in patients with anxious depression MMEM concentration was elevated almost twofold supports this thesis. It is postulated that during the development of the psychic process there is an activation of catabolic processes that increase of the concentration of different MMEM (Lamperi et al, 1979;Turianitsa et al, 1988;Uzbekov et al, 1995). Many components of MMEM fraction are possessed of toxic properties and can inhibit different metabolic and physiologic processes (Kovalevskii and Nifantieva, 1989;Ringoir et al, 1987).…”

“…Middle-mass endotoxic molecules (MMEM) represent a fraction of different blood plasma substances with the molecular mass of 300-5000 Dalton (Babb et al, 1972;Ringoir et al, 1987). The increase of the MMEM concentration in blood plasma is indicative of the aggravation of the degree of endotoxicosis (Chalenko, 1991;Lamperi et al, 1979;Turianitsa et al, 1988;Umanskii et al, 1991;Uzbekov and Misionzhnik, 2000;Uzbekov et al, 1995). For the evaluation of the degree of endotoxicosis, we have estimated MMEM concentration in blood plasma by method of Babb et al (1972) in modification of Nikolaichik et al (1991).…”