Dynamic Imaging of Functionalized Multi‐Walled Carbon Nanotube Systemic Circulation and Urinary Excretion

Lacerda, Lara; Soundararajan, Anuradha; Singh, Ravi; Pastorin, Giorgia; Al‐Jamal, Khuloud T.; Turton, John; Frederik, Peter M.; Herrero, M. Antonia; Li, Shouping; Bao, Ande; Emfietzoglou, Dimitris; Mather, Stephen J.; Phillips, William T.; Prato, Maurizio; Bianco, Alberto; Goins, Beth; Kostarelos, Kostas

doi:10.1002/adma.200702334

Cited by 195 publications

(154 citation statements)

References 34 publications

(18 reference statements)

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“…This molecule has also served as a substrate to anchor the gamma-emitting radionuclide, and this nanosystem was followed by a microSPECT/computer tomography; the authors proposed that the elimination mechanism of MWCNTs observed was due to the rapid desorption of the radionuclide attached to the MWCNTs in the blood. 17 Marega et al used functionalized Fe-filled MWCNTs as multifunctional scaffolds for magnetization of cancer cells; they anchored monoclonal antibodies (mAbs) against cancer cells on the surface of Fe-filled MWCNTs to evaluate the confinement of magnetically active Fe phases and the immobilization of mAbs on MWCNTs surface. 18 de Faria et al investigated the efficiency of a hybrid supramolecule as an anticancer vaccine; it included MWCNTs as a delivery system for NY-ESO-1, which is a cancer antigen, and a Tolllike receptor agonist; this strategy restrained the tumoral growth.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity induced by carbon nanotubes in experimental malignant glioma

Romano-Feinholz¹,

Salazar-Ramiro

Muñoz‐Sandoval³

et al. 2017

IJN

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Despite multiple advances in the diagnosis of brain tumors, there is no effective treatment for glioblastoma. Multiwalled carbon nanotubes (MWCNTs), which were previously used as a diagnostic and drug delivery tool, have now been explored as a possible therapy against neoplasms. However, although the toxicity profile of nanotubes is dependent on the physicochemical characteristics of specific particles, there are no studies exploring how the effectivity of the carbon nanotubes (CNTs) is affected by different methods of production. In this study, we characterize the structure and biocompatibility of four different types of MWCNTs in rat astrocytes and in RG2 glioma cells as well as the induction of cell lysis and possible additive effect of the combination of MWCNTs with temozolomide. We used undoped MWCNTs (labeled simply as MWCNTs) and nitrogen-doped MWCNTs (labeled as N-MWCNTs). The average diameter of both pristine MWCNTs and pristine N-MWCNTs was ~22 and ~35 nm, respectively. In vitro and in vivo results suggested that these CNTs can be used as adjuvant therapy along with the standard treatment to increase the survival of rats implanted with malignant glioma.

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Section: Introductionmentioning

confidence: 99%

Cytotoxicity induced by carbon nanotubes in experimental malignant glioma

Romano-Feinholz¹,

Salazar-Ramiro

Muñoz‐Sandoval³

et al. 2017

IJN

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“…In particular, several investigations aimed to evaluate the biodistribution of various functionalized CNTs and any potential adverse reaction. [25][26][27][28][29][30][31] Some of us previously reported that the surface functionalization of multiwalled CNTs determines the tissue distribution and excretion profile after intravenous administration. 29 The modifications with polyethylene glycol (PEG) or PEG-derived polymers…”

Section: Introductionmentioning

confidence: 99%

“…35 Also, small-sized nano-carbons were able to cross the glomerular filtration slits (40 nm) 28 more comfortably than L-CNHs.…”

mentioning

confidence: 99%

“…[25][26] Adequately functionalized multiwalled CNTs radiolabeled with [ 111 In] are retained in the reticuloendothelial system organs, such as the liver and spleen, but are also rapidly cleared from systemic blood circulation through the renal excretion route. 27,28 The influence of type and degree of functionalization on the fate of injected CNTs has also been evaluated. 29 However, the effect of other structural parameters like the particle size (ie, short versus long) and shape (ie, small versus large diameter) has not been fully understood.…”

mentioning

confidence: 99%

“…For this purpose, the labeling process was performed by an amidation reaction of oxidized CNHs with the chelating agent diethylenetriaminepentaacetic acid (DTPA), an approach that has been successfully used to investigate the pharmacokinetic profiles of CNTs. [27][28][29] By using this functionalization strategy, we can directly visualize the dynamic distribution of CNHs in whole body using single-photon emission computed tomography/computed tomography (SPECT/ CT) and quantitatively calculate the organ distribution using gamma scintigraphy. The data allowed comparison of the differences between S-CNHs and L-CNHs in organ accumulation as well as in their excretion profiles.…”

mentioning

confidence: 99%

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Radiolabeling, whole-body single photon emission computed tomography/computed tomography imaging, and pharmacokinetics of carbon nanohorns in mice

Zhang

Jasim

Ménard‐Moyon

et al. 2016

IJN

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In this work, we report that the biodistribution and excretion of carbon nanohorns (CNHs) in mice are dependent on their size and functionalization. Small-sized CNHs (30–50 nm; S-CNHs) and large-sized CNHs (80–100 nm; L-CNHs) were chemically functionalized and radiolabeled with [ 111 In]-diethylenetriaminepentaacetic acid and intravenously injected into mice. Their tissue distribution profiles at different time points were determined by single photon emission computed tomography/computed tomography. The results showed that the S-CNHs circulated longer in blood, while the L-CNHs accumulated faster in major organs like the liver and spleen. Small amounts of S-CNHs- and L-CNHs were excreted in urine within the first few hours postinjection, followed by excretion of smaller quantities within the next 48 hours in both urine and feces. The kinetics of excretion for S-CNHs were more rapid than for L-CNHs. Both S-CNH and L-CNH material accumulated mainly in the liver and spleen; however, S-CNH accumulation in the spleen was more prominent than in the liver.

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Functionalized Carbon Nanotubes for Bioapplications

Luo

et al. 2010

The Supramolecular Chemistry of Organic‐Inorganic Hybrid Materials

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Dynamic Imaging of Functionalized Multi‐Walled Carbon Nanotube Systemic Circulation and Urinary Excretion

Cited by 195 publications

References 34 publications

Cytotoxicity induced by carbon nanotubes in experimental malignant glioma

Cytotoxicity induced by carbon nanotubes in experimental malignant glioma

Radiolabeling, whole-body single photon emission computed tomography/computed tomography imaging, and pharmacokinetics of carbon nanohorns in mice

Functionalized Carbon Nanotubes for Bioapplications

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