Dynamic contrast-enhanced magnetic resonance imaging of human cervical carcinoma xenografts: Pharmacokinetic analysis and correlation to tumor histomorphology

Evaluation of Tumor-associated Stroma and Its Relationship with Tumor Hypoxia Using Dynamic Contrast-enhanced CT and18F Misonidazole PET in Murine Tumor Models

“…Previously, some studies have reported on the imaging of tumor-associated stroma (9,13,22,30,31). Ko et al (4) showed that apparent diffusion coefficient values were lower in the stroma-poor group than in the stroma-rich quantified with immunohistochemistry; this finding supported our hypothesis that DCE CT had the potential to depict a similar spatial distribution of tumor-associated stroma to that confirmed with histopathologic analysis.…”

“…Then, to investigate the relationship between tumor hypoxia and the vascular component, (30); however, there has been some controversy. Ellingsen et al (31) reported the lack of a correlation between their imaging parameters and the stroma and concluded that the potential of DCE MR imaging was limited. Furthermore, with DCE MR imaging, the concentration of the gadoliniumcontaining agent is considered not to be proportional to the detected signal changes (32), while it is assumed that the concentration of the iodinated agent is proportional to the measured attenuation at DCE CT (33).…”

Dynamic contrast-enhanced MRI of the microenvironment of pancreatic adenocarcinoma xenografts

“…These MR similarities are also interesting because the melanoma, cervix carcinoma, and PDAC xenografts differed considerably in histological appearance [26,[46][47][48][49]. The PDAC and cervix carcinoma xenografts both developed substantial stroma, but the connective tissue was more extensive and the density of collagen fibers was higher in the PDAC than in the cervix carcinoma xenografts.…”

On the relationship between the apparent diffusion coefficient and extravascular extracellular volume fraction in human breast cancer

“…Though such a relationship did not exist in our study (data not shown), it is possible that the elimination of necrotic regions can improve the relationship between v e and ADC; but this would be very difficult to assess without ex vivo (post-mortem) alignment of histological data to imaging data—data that is difficult to acquire in clinical studies. However, another pre-clinical study did not find a strong correlation between v e (or K trans ) and histomorphological parameters [25]. The authors concluded this was mostly likely due the heterogeneity of tumor tissue found at the sub-voxel level.…”