MRI techniques have been developed that can noninvasively probe the apparent diffusion coefficient (ADC) of water via diffusion weighted MRI (DW-MRI). These methods have found much application in cancer where it is often found that the ADC within tumors is inversely correlated with tumor cell density, so that an increase in ADC in response to therapy can be interpreted as an imaging biomarker of positive treatment response. Dynamic contrast enhanced MRI (DCE-MRI) methods have also been developed and can noninvasively report on the extravascular extracellular volume fraction of tissues (denoted by ve). By conventional reasoning the ADC should therefore also be directly proportional to ve. Here we report measurements of both ADC and ve obtained from breast cancer patients at both 1.5T and 3.0T. The 1.5T data were acquired as part of normal standard-of-care, while the 3.0T data were obtained from a dedicated research protocol. We found no statistically significant correlation between ADC and ve for the 1.5T or 3.0T patient sets on either a voxel-by-voxel or ROI basis. These data, combined with similar results from other disease sites in the literature, may indicate that the conventional interpretation of either ADC, ve, or their relationship are not sufficient to explain experimental findings.

Purpose: To evaluate the efficacy of trabeculectomy with intraoperative subtenon injection of Mitomycin C (MMC) in terms of control of Intraocular pressure post-operatively.Study design: Observational studyMethods: A total of 49 patient’s medical records who underwent trabeculectomy with intraoperative subtenon injection of MMC with diagnosis of Primary Open Angle Glaucoma (POAG) from January 2017 to December 2018 were evaluated to see the post-operative outcomes in terms of control of intraocular pressure (IOP) with 12 months follow-up. The medical records were retrieved using the hospital information system. Age, gender, pre-operative IOP, Best-Corrected Visual Acuity (BCVA), co-morbids, previous surgery, Central Corneal Thickness (CCT), fundus findings, number of glaucoma medications and postoperative complications were obtained by using a proforma.Results: Total 72 eyes of 49 patient records were evaluated to see post operative outcomes at three, six and twelve months follow up. The mean IOP preoperatively was 24.68±13.66 mm Hg with maximum anti-glaucoma treatment. After the surgery the mean IOP was 13.69±6.68 mmHg at 3 months follow-up, and 12.68±4.04 and 13.33±4.8 mmHg at 6 and 12 months respectively (P-value 0.001). Preoperatively mean CCT was 529.81±28.75 and at 12 months follow-up after surgery was 530.45±29.43 with P-value 0.245. Best Corrected Visual Acuity outcomes were seen at each follow-up and results were found to be statistically significant (P value ≤ 0.05).Conclusions: Twelve months follow-up of trabeculectomy show that intraoperative subtenon injection of MMC is effective in terms of control of IOP postoperatively with minimal complications in patients with POAG.

Ocular hypertension and glaucoma can occur after blunt trauma to the eye. Careful gonioscopic examination of the anterior chamber angle will reveal angle recession with widened ciliary body. We describe three cases of blunt trauma to the eye resulting in raised intraocular pressure (IOP)with and without damage to the optic disc. Two of these patients with high IOP were controlled medically while third patient required surgical intervention. The risk of high IOP after trauma can occur earlier or in the later part of the life. Patients with history of blunt injury to the eye should therefore be educated and counselled to get their eyes periodically examined for an early diagnosis of increased IOP

refractory disease (n Z 49) (P Z 0.26). 3-year PFS was 80%, 67%, and 54%, respectively (P Z 0.12). In patients with progressive disease limited to 1 side of the diaphragm, 3-year OS was 100% (relapsed, with RT), 91% (relapsed, no RT), and 72% (refractory) (P Z 0.01), and PFS was 80%, 74%, and 56% (P Z 0.09), respectively. One case of grade >2 RT-related toxicity was observed. This patient had grade 3 cytopenia. Conclusion: This series, the largest of its kind, suggests that patients experience improved outcomes and limited toxicity when RT is provided after SCT for relapsed/refractory HL. Small sample size and selection bias limit the results. Prospective study is warranted.