Dynamic Changes in Inhibin Messenger RNAs in Rat Ovarian Follicles During the Reproductive Cycle

Woodruff, Teresa K.; D'Agostino, Jo Beth; Schwartz, Neena B.; Mayo, Kelly E.

doi:10.1126/science.3125611

Cited by 245 publications

(125 citation statements)

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“…In the pituitary, FSH is stimulated by locally produced activin, and ovarianderived inhibin antagonizes activin (17,42,(45)(46)(47). Inhibin shares its ␤-subunit with activin, and can compete with activin for binding with ActRII/IIB; however, inhibin binding affinity to ActRII/IIB is 2-10ϫ lower than activin binding affinity to ActRII/IIB (6, 8, 48 -50).…”

Section: Discussionmentioning

confidence: 99%

“…Inhibin is the only known endocrine hormone in the TGF␤ superfamily and plays an essential role in the negative feedback between the gonads and the pituitary gland that is necessary for the regulation of reproductive function (41)(42)(43)(44). In the pituitary, FSH is stimulated by locally produced activin, and ovarianderived inhibin antagonizes activin (17,42,(45)(46)(47).…”

Section: Discussionmentioning

confidence: 99%

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Inhibin α-Subunit N Terminus Interacts with Activin Type IB Receptor to Disrupt Activin Signaling

Zhu

Lin

Zou

et al. 2012

Journal of Biological Chemistry

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Background:The inhibin ␤-subunit interacts with activin type II receptor to antagonize activin signaling. Results: The inhibin ␣-subunit N terminus binds ALK4 to antagonize activin signaling. Conclusion: Inhibin ␣-subunit binding to ALK4 supports potent antagonism of constitutive activin-stimulated FSH production in pituitary cells. Significance: Understanding the mechanisms underlying control of pituitary FSH synthesis may provide treatment approaches to reproductive endocrine disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Inhibin α-Subunit N Terminus Interacts with Activin Type IB Receptor to Disrupt Activin Signaling

Zhu

Lin

Zou

et al. 2012

Journal of Biological Chemistry

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“…The other female reproductive system an unique model to study the diverse role of inhibins [35][36][37]. Ovarian inhibin is primarily expressed in follicles and its presence in the corpus luteum (CL) is species specific [38]. The primate CL is unique, in that along with progesterone (P 4 ) biosynthesis, it also synthesizes substantial amounts of estradiol (E 2 ) and inhibin A isoform.…”

Section: B Inhibins In Female Gonadsmentioning

confidence: 99%

New targets for old hormones: inhibins clinical role revisited [Review]

2011

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Abstract. Inhibins are gonadal peptide hormones belonging to the transforming growth factor-β (TGF-β) superfamily that regulate the pituitary follicle stimulating hormone (FSH) secretion by negative feedback mechanisms. It is evident that the understanding of inhibins function in the hypothalamic-pituitary-gonadal axis will provide insights into physiology and pathology of the gonadal function. In recent years, a great deal of attention has been focussed on clinical relevance of measuring circulating inhibins in normal and disease state. The past few years also have witnessed the emergence and discovery of extra pituitary action of inhibins that might provide further insights into the underlying diseases like cancer especially in the reproductive axis and various other new endocrine target organs. In this review after systematic analysis of literature, we discuss briefly the known and recent advances in function of these hormones highlighting also its structure, production and mechanisms of signal transduction. Also this review discusses about the physiological relevance of inhibin association in the normal function to the development of reproductive cancers. Finally, we describe evidence from various emerging studies that inhibins make an important contribution to other physiological functions apart from reproduction which reveals new endocrine target organs of inhibins. The emerging view is inhibin participates in multiple ways to regulate the function in different cell types and still complete repertoire of its actions is under investigation. Key words: Inhibin, Transforming growth factor, Ovarian cancer, Activins, BetaglycanMAMMAliAn reproduction is intricate, highly ordered and is coordinated by assorted neural, neuroendocrine, endocrine, autocrine and paracrine cell-cell communication pathways. Many of the pioneering discoveries meticulously demonstrated the roles of hypothalamic gonadotropin releasing hormone (GnRH) that stimulates pituitary gonadotropins such as follicle stimulating hormone (FSH) and leutinizing hormone (LH), which directly control gonadal functions. Subsequent breakthroughs in the advancement of molecular biology and in understanding signal transduction mechanisms suggested involvement of various cytokines and growth factors at each level of the hypothalamic-pituitary-gonadal axis in the paracrine/autocrine control of different programmed reproductive events. Members include inhibins and activins, belonging to the transforming growth factor (TGF-β) super family and follistatin (FS), a structurally distinct though functionally related molecule. It has been more than 70 years since the identification of negative feedback control of pituitary FSH secretion by inhibins. These factors also were shown to act in autocrine, endocrine or paracrine manner within the reproductive tissues, but the identification of specific pathways in different cellular context along the gonadal axis is still quite unclear and should thus be further investigated. The discovery process of extra pituitary action of ...

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“…nhibin is a glycoprotein with a molecular weight of 32 kDa and a heterodimer consisting of an α-subunit (20 kDa) and one of two β-subunits (βA or βB; 13 kDa) linked by disulfide bridges, and the α-and β-subunits are produced by different genes [1][2][3][4][5][6][7][8][9][10]. Inhibin is mainly produced by the granulosa cells of the ovaries, and its major physiological role is specific suppression of secretion of folliclestimulating hormone (FSH) from the anterior pituitary gland [1][2][3][4][5][6][7][8][9][10][11][12][13][14].…”

mentioning

confidence: 99%

“…Inhibin is mainly produced by the granulosa cells of the ovaries, and its major physiological role is specific suppression of secretion of folliclestimulating hormone (FSH) from the anterior pituitary gland [1][2][3][4][5][6][7][8][9][10][11][12][13][14]. Many studies of inhibin activity estimated by radioimmunoassay and/or bioassay have demonstrated that growing healthy follicles produce and secrete much more inhibin into follicular fluid than atretic follicles [4,5,7,9,[15][16][17][18].…”

mentioning

confidence: 99%

Stage-Specific Distributions of Inhibin .ALPHA.-subunit in Bovine Ovarian Follicles and Various Hormones Levels in Follicular Fluid.

Yoshimura¹,

Hondo²,

Murabayashi³

et al. 1999

Journal of Reproduction and Development

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Abstract. The changes in localization of inhibin α-subunit in bovine ovarian follicles during follicular development were assessed by immunohistochemical staining with monoclonal anti-inhibin α-subunit antibody. The changes in inhibin, estradiol-17β (E2), progesterone (P) and testosterone (T) levels in the follicular fluid during follicular development were also investigated. The follicles obtained from the bovine ovaries in mid-luteal stage were histologically classified into 7 stages. Stages I, II and III were growing healthy follicles, and stages IV, V, VI and VII were atretic follicles. In both growing and atretic follicles, inhibin α-subunit were histochemically demonstrated in the granulosa cells. Strong or moderate immunostaining for inhibin α-subunit were found only in the granulosa cells of stages II and III follicles (the strongest staining was found in stage III), and trace staining was seen in a small number of theca interna cells of stages II and III follicles. The granulosa cells of early atretic follicles (stage IV) also have the ability to produce and secrete inhibin, but finally they lost the ability. No positive staining was demonstrated in any cells of progressed atretic follicles (stage V, VI and VII). Inhibin level in the follicular fluid was higher in the growing follicles (highest level at stage II) than in the atretic follicles. Follicular fluid E2 level increased from stages I to III, but decreased from stage IV onward. The P levels remained low from stages I to VI, but increased only in stage VII. The T levels in stages III and VII were lower than in the other stages. Follicular fluid inhibin level were related to E2 level but not P or T levels. In conclusion, the inhibin α-subunit is produced by follicular granulosa cells in growing follicles of the bovine ovaries, and inhibin may stimulate E2 secretion in growing but not in atretic follicles.

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Dynamic Changes in Inhibin Messenger RNAs in Rat Ovarian Follicles During the Reproductive Cycle

Cited by 245 publications

References 32 publications

Inhibin α-Subunit N Terminus Interacts with Activin Type IB Receptor to Disrupt Activin Signaling

Inhibin α-Subunit N Terminus Interacts with Activin Type IB Receptor to Disrupt Activin Signaling

New targets for old hormones: inhibins clinical role revisited [Review]

Stage-Specific Distributions of Inhibin .ALPHA.-subunit in Bovine Ovarian Follicles and Various Hormones Levels in Follicular Fluid.

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