Durchblutung und Sauerstoffaufnahme des Hirns unter Neuroleptanalgesie

Kreuscher, H.

doi:10.1007/978-3-642-46029-6_18

Cited by 4 publications

(4 citation statements)

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“…pressure noted with droperidol and fentanyl in these investigations is consequent upon a reduction in cerebral blood flow, possibly secondary to a decrease in cerebral metabolism. This hypothesis is supported by the finding of Kreuscher (1965) of a 50 per cent reduction in both cerebral blood flow and cerebral metabolic rate with associated slowing of the e.e.g. with droperidol and fentanyl in the dog.…”

Section: Patients With Intracranial Space-occupyingmentioning

confidence: 73%

The Influence of Neuroleptanalgesic Drugs on Cerebrospinal Fluid Pressure

Fitch

Barker

Jennett

et al. 1969

British Journal of Anaesthesia

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The effects of the neuroleptanalgesic drug combinations, droperidol 5 mg + phenoperidine 1.5 mg, and droperidol 5 mg + fentanyl 0.1 mg, on the cerebrospinal fluid (c.s.f.) pressure, have been studied in patients with normal c.s.f. pathways during controlled ventilation. The influence of droperidol 5 mg+fentanyl 0.1 mg on intracranial pressure has also been investigated in patients with intracranial space-occupying lesions. In patients with normal c.s.f. pathways, droperidol and phenoperidine produced only small alterations in c.s.f. pressure in either direction, while droperidol plus fentanyl resulted in falls in c.s.f. pressure in each case studied, with a significant decrease in overall mean c.s.f. pressure. Similarly, in patients with intracranial space-occupying lesions, droperidol plus fentanyl produced decreases in c.s.f. pressure in all but one of the cases studied. The striking difference between the effect on c.s.f. pressure of these drugs and of the volatile anaesthetic agents could be of importance to the clinical anaesthetist dealing with head injuries or working in a neurosurgical unit, when under conditions of controlled ventilation these drugs could be used as adjuvants to nitrous oxide-oxygen anaesthesia.

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Section: Patients With Intracranial Space-occupyingmentioning

confidence: 73%

The Influence of Neuroleptanalgesic Drugs on Cerebrospinal Fluid Pressure

Fitch

Barker

Jennett

et al. 1969

British Journal of Anaesthesia

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“…In animal experiments, Kreuscher (1965) showed a 50% reduction of both c.b.f. and cerebral metabolic rate in dogs after the administration of droperidol and fentanyl.…”

Section: Discussionmentioning

confidence: 94%

“…Nilsson and Ingvar (1966) reported that both phenoperidine and fentanyl increased the blood flow in the cerebral cortex of cats, possibly as a result of increased cerebral oxygen consumption. Kreuscher (1965), however, found that droperidol and fentanyl decreased the cerebral blood flow in dogs.…”

mentioning

confidence: 90%

The Effects of Thalamonal on Cerebral Circulation and Oxygen Consumption in Man

Sari

Okuda

Takeshita

1972

British Journal of Anaesthesia

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“…Previous studies of the effects of drugs on cerebral blood flow showed that, in dogs, the combination droperidol-fentanyl caused a decrease in c.b.f. (Kreuscher, 1965), but, later Barker and others (1968) found no significant changes using the same combination. Furthermore, the decrease in cerebral flow was correlated with the decrease in CMRo 2 in animals (Miller and Barker, 1969;Michenfelder and Theye, 1971), whereas the variations in c.b.f.…”

Section: Discussionmentioning

confidence: 89%