In order to reduce pain caused by the affected hip joint, unilateral hip osteoarthritis patients (HOAP) adopt characteristic gait patterns. However, it is unknown if the knee and hip joint loading in the non-affected (limb ) and the affected (limb ) limb differ from healthy controls (HC) and which gait parameters correlate with potential abnormal joint loading. Instrumented 3D-gait analysis was performed on 18 HOAP and 18 sex, age, and height matched HC. The limb showed greater first and second peak external hip adduction moments (first HAM: +15%, p = 0.014; second HAM: +15%, p = 0.021, respectively), than seen in HC. In contrast, the second peak external knee adduction moment (KAM) in the limb is reduced by about 23% and 30% compared to the limb and HC, respectively. Furthermore, our patients showed characteristic gait compensation strategies including reduced peak vertical forces (pvF), a greater foot progression angle (FPA), and reduced knee range of motion (ROM) in the limb . The limb was 5.6 ± 3.8 mm shorter than the limb . Results of stepwise regression analyses showed that increased first pvF explain 16% of first HAM alterations, whereas knee ROM and FPA explain 39% of second KAM alterations. We therefore expect an increased rate of progression of OA in the hip joint of the limb and suggest that the shift in the medial-to-lateral knee joint load distribution may impact the rate of progression of OA in the limb . The level of evidence is III. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1764-1773, 2017.

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SYNOPSIS Twenty patients with aneurysms of the internal carotid artery underwent temporary clamping, in turn, of the internal and then the common carotid artery. Cerebral blood flow, internal carotid artery pressure, and the EEG were recorded to assess the probability of cerebral ischaemia after permanent ligation. With this method of monitoring the cerebral circulation, 17 of the 20 patients had a permanent carotid ligation without neurological deficit; in the other three ligation was contraindicated. Although a correlation was observed between the reduction of cerebral blood flow and the fall in internal carotid artery pressure caused by temporary clamping (P < 0 01), the scatter of data was too wide to predict cerebral blood flow from the change in carotid artery pressure. Similarly, EEG slowing was usually associated with low cerebral blood flow but exceptions occurred. Ligation was safe when, during temporary clamping, cerebral blood flow exceeded 40 ml/100 g/min, but was deemed unsafe when flow was less than 20 ml/100 g/min. In the range 20-40 ml/100 g/min, consideration of the internal carotid artery pressure permitted more patients to be safely ligated than if the decision had rested on changes in cerebral blood flow alone.Permanent ligation of a carotid vessel in the neck is a widely used method of treating certain intracranial aneurysms and recent studies have confirmed its efficacy in providing lasting protection from recurrent subarachnoid haemorrhage (German and Black, 1965;Sahs et al., 1973). Although a more simple operation than intracranial clipping of an aneurysm, it carries the risk of producing ischaemia of the ipsilateral cerebral hemisphere, reported to occur in 3000 of the aggregate series of 785 carotid ligation operations in the Co-operative Aneurysm Study (Nishioka, 1966). In 21% of these cases the signs ofischaemia were delayed for more than 48 hours after ligation, and recent evidence suggests that deficits of delayed onset are more likely to be permanent than are ischaemic complications occurring in the first few hours after ligation (Landolt and Millikan, 1970 . Although such patients are spared the risk of hemiplegia, their original condition remains untreated, and they face the hazard of this and of an alternative