Effects of a Diazepam-Fentanyl Mixture on Cerebral Blood Flow and Oxygen Consumption in Man

Hemodynamics and Cerebral Oxygenation Following Repair of Tetralogy of Fallot: The Effects of Converting From Positive Pressure Ventilation to Spontaneous Breathing

“…8 As a result, the cerebral arterial-venous oxygen content difference (AVDO 2 ) remains fairly constant. [9][10][11] This "autoregulation" is mediated by changes in cerebral vascular resistance. 8 If systemic perfusion were to increase, a compensatory increase in cerebral vascular resistance would limit increases in CBF and the cerebral AVDO 2 would remain fairly constant.…”

The steady‐state and rebreathing methods compared during morphine administration in humans.

“…We are unable to find any specific data to support this hypothesis. However, the central time constant is known to be inversely proportional to cerebral blood flow and, despite some controversy, there is considerable evidence that narcotics reduce cerebral blood flow (Takeshita, Michenfelder & Theye, 1972;Vernhiet, Renou, Orgogozo, Constant & Caille, 1978;Carlsson, Smith, Keykhah, Englebach & Harp, 1982). It should be noted that most of the research relating narcotics to reductions in cerebral blood flow has been done with much higher, that is, anaesthetic, doses (1-3 mg kg-') of morphine than the analgesic doses (0 07 and 0-21 mg kg-1) used in our study.…”

“…It should be noted that most of the research relating narcotics to reductions in cerebral blood flow has been done with much higher, that is, anaesthetic, doses (1-3 mg kg-') of morphine than the analgesic doses (0 07 and 0-21 mg kg-1) used in our study. Although the effect of narcotics on CO2 regulation of cerebral blood flow has not been studied extensively, one report (Vernhiet et al 1978) suggests that it remains intact. None the less, based on the available studies, one can estimate that 0-21 mg kg-1 MS could reduce cerebral blood flow by as much as 15% (Takeshita et al 1972).…”

Cerebral Blood Flow Velocity Assessed by Doppler Technique after Intravenous Application of Diazepam in Very Low Birth Weight Infants

“…It has been well studied for side effects on the particularly interesting cere bral blood flow in animals [1][2][3][4] and human adults [5][6][7][8] usually revealing a decrease af ter the administration of diazepam in thera peutic doses. Its pharmacokinetics have been explored as well [9][10][11][12], Diazepam has also been proposed for treatment of neonatal seizures [ 13].…”