Duration of fertility after fresh and frozen ovary transplantation

Silber, Sherman J.; Kagawa, N.; Kuwayama, Masashige; Gosden, Roger G.

doi:10.1016/j.fertnstert.2009.12.073

Cited by 220 publications

(175 citation statements)

References 69 publications

(62 reference statements)

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“…It was validated by our group for human ovarian tissue, first experimentally using a murine xenotransplantation model [38], and then clinically by obtaining the first pregnancy after transplantation of cryopreserved ovarian tissue [14]. So far, slow-freezing using DMSO with or without sucrose [8,10,14,35,41,44], propanediol/sucrose [56] or ethylene glycol/sucrose [4] as cryoprotectants are the methods of choice for cryobanking of human ovarian tissue, as these procedures have been shown to restore fertility. Despite working very hard on other protocols (vitrification) in experimental models [3], we have not gathered enough scientific data to modify the slow-freezing protocol.…”

Section: Incidence Of Indications and Comparison With Other Reportsmentioning

confidence: 99%

A review of 15 years of ovarian tissue bank activities

Dolmans

Jadoul

Gilliaux

et al. 2013

J Assist Reprod Genet

109

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Purpose To review 15 years of activities in ovarian tissue cryobanking from medical database files, including patient indications, histological evaluation and clinical characteristics. Methods Retrospective longitudinal analysis of data from an ovarian tissue bank in an academic hospital. Five hundred and eighty-two patients had their ovarian tissue cryobanked between April 1997 and January 2012. Analysis of cryobanking database: precryopreservation patient characteristics, indications and safety issues, laboratory files and postcryopreservation clinical data. Results Of the 582 patients who had their ovarian tissue cryopreserved, 106 patients donated for research purposes and 476 patients for fertility preservation and long-term cryopreservation. Clinical data analysis of the 476 patients revealed a mean age at the time of cryopreservation of 23± 8.5 years (range: 9 months -39 years), with 96.2 % of subjects aged ≤35 years (n=458). Among 391 cases of malignant disease, hematological malignancies (39.9 %, n=156) and breast cancer (21.7 %, n=85) were the two main indications.At histology, malignant cells were found in ovarian tissue from leukemia patients (n = 3) and non-Hodgkin's lymphoma patients (n=2). Eleven patients underwent autotransplantation, resulting in 5 live births and 1 ongoing pregnancy. Conclusion This is the largest and most comprehensive study to describe and analyze indications and clinical patient characteristics before and after ovarian tissue cryopreservation. The procedure is safe, easy and promising. The database concept is a useful tool in patient selection for autotransplantation.

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Section: Incidence Of Indications and Comparison With Other Reportsmentioning

confidence: 99%

A review of 15 years of ovarian tissue bank activities

Dolmans

Jadoul

Gilliaux

et al. 2013

J Assist Reprod Genet

109

View full text Add to dashboard Cite

show abstract

“…Ovarian tissue removal, cryopreservation, and later transplantation back into an individual has successfully restored both fertility and endocrine function [14][15][16]. In fact, autologous transplantations of thawed ovarian cortical tissue have resulted in 17 reported live births [17][18][19][20][21][22][23][24][25][26][27][28][29][30]. However, the data surrounding ovarian transplantation is controversial because typically only positive outcomes are reported, thus obscuring the success rate.…”

Section: Introductionmentioning

confidence: 99%

Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue

Laronda

Duncan

Hornick

et al. 2014

J Assist Reprod Genet

112

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“…The recently described technique of vitrification for freezing of ovarian tissue seems to improve viability of all compartments of the cortex with a similar follicular survival rate, but with much improved integrity of ovarian stroma and morphology of blood vessels than the slow-freezing technique [50,51]. Vitrification involves equilibration of the specimen in one or more cryoprotectants followed by plunging into liquid nitrogen.…”

Section: Ovarian Tissue Freezingmentioning

confidence: 99%

“…Orthotopic transplantation of tissue seems to provide an improved ovarian function, both hormonal and for fertility purposes [66]. While ovarian function restoration has been proven to be possible and prolonged after fresh and frozen cortex transplant [51,67], fertility outcomes are still reported as isolated cases. The current literature reports the number of pregnancies achieved, but there is no mention of how many patients underwent autologous transplants to yield those pregnancies.…”

Section: Ovarian Cortical Tissue Transplantmentioning

confidence: 99%

Applicability of adult techniques for ovarian preservation to childhood cancer patients

Detti

Williams

2012

J Assist Reprod Genet

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Purpose To appraise the feasibility of current adult medical and surgical techniques for ovarian preservation in prepubertal and adolescent girls with cancer. Methods Literature search using PubMed and SCOPUS up to February 2012. In addition, the reference lists of selected studies and all identified systematic and narrative reviews were scanned for relevant references. Inclusion criteria were ovarian preservation and cancer. Exclusion criteria were non-English publications, letters, personal communications, and ovarian preservation for conditions other than cancer. Results Data from the selected publications was interpreted and discussed in the relevant sections. Cryopreservation of ovarian tissue followed by autologous transplant represents the only surgical option available for pre-pubertal girls and adolescents who cannot delay the start of chemotherapy. Few studies report on pre-pubertal and adolescent girls undergoing ovarian preservation surgeries with good harvesting, and no follow-up has been conveyed, to date. Outcomes of ovarian function after ovarian suppression with GnRH-analogs in adults have been controversial and no reports are available for pre-pubertal girls. Conclusions Autologous transplantation of cryopreserved ovarian cortex probably represents the best option for preservation of fertility and hormonal function in childhood cancer females; however, future research needs to address the safety of this technique, especially in patients with blood-borne cancers. Ovarian suppression with GnRHanalogs at the time of chemotherapy treatment has not proven to be superior to non-suppression for fertility preservation purposes in adults. Not enough evidence is presently available in childhood cancer patients.

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Duration of fertility after fresh and frozen ovary transplantation

Cited by 220 publications

References 69 publications

A review of 15 years of ovarian tissue bank activities

A review of 15 years of ovarian tissue bank activities

Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue

Applicability of adult techniques for ovarian preservation to childhood cancer patients

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