A review of 15 years of ovarian tissue bank activities

Dolmans, Marie-Madeleine; Jadoul, Pascale; Gilliaux, Sébastien; Amorim, Christiani Andrade; Luyckx, Valérie A.; Squifflet, Jean; Donnez, Jacques; Langendonckt, Anne Van

doi:10.1007/s10815-013-9952-x

Cited by 109 publications

(79 citation statements)

References 61 publications

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“…For male fertility restoration, the utilization rate by cancer survivors who banked sperm prior to cancer treatment is curiously less than 10 % [15]. For cryopreserved ovarian tissue, the utilization rate was calculated to be 2.3 % in 2012 [16] but the number of patients undergoing ovarian tissue transplantation is increasing all the time as these women decide to attempt pregnancy. The latest figures for 2015 show the rate to be 3.5-8 %.…”

Section: Utilization Ratementioning

confidence: 99%

Utilization rates and results of long-term embryo cryopreservation before gonadotoxic treatment

Dolmans

Ouderaen

Demylle

et al. 2015

J Assist Reprod Genet

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Purpose The aim of this study was to evaluate long-term embryo cryopreservation, utilization, and success rate in patients subjected to gonadotoxic treatments in the context of cancer. Methods This is a retrospective study on patients (n=54) undergoing ovarian stimulation and IVF for fertility preservation between January 1997 and June 2014. Embryos were slowfrozen and stored until the women were cured and able to undergo embryo transfer. Results Fifty-four women underwent 66 oocyte pick-up procedures in total, and embryos were obtained from 52 of the 54 patients. Four patients died before their frozen embryos could be thawed. Of the remaining 48, 9 women returned to use their embryos, resulting in 6 pregnancies (66 % cumulative pregnancy rate), two of which ended in miscarriage. The live birth rate per patient was thus 44 % (4/9). The true come-back rate, calculated after applicable exclusions, was found to be 23 %. Conclusion IVF followed by embryo freezing is a widely established technique for fertility preservation, but little has been published on the outcomes in cancer patients. While we found the number of good-quality embryos to be lower than in a normal population, the cumulative live birth rate was similar to that achieved with fresh embryos in non-cancer patients. The utilization rate of this fertility preservation method can be considered high.

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Section: Utilization Ratementioning

confidence: 99%

Utilization rates and results of long-term embryo cryopreservation before gonadotoxic treatment

Dolmans

Ouderaen

Demylle

et al. 2015

J Assist Reprod Genet

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“…Twenty eight live pregnancies have been achieved with orthotopic ovarian tissue transplant from patients with haematological malignancies and breast cancer [29]. Currently about 100 centres worldwide perform ovarian tissue cryopreservation [13].…”

Section: Fertility Preservation Options For Female Patientsmentioning

confidence: 99%

Fertility preservation in cancer patients: The global framework

Linkeviciute

Boniolo

Chiavari

et al. 2014

Cancer Treatment Reviews

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Cancer treatment is the most frequent cause of reduced fertility in cancer patients, with up to 80% of survivors affected. None of the established or experimental fertility preservation methods can assure parenthood; instead it may provide a future opportunity to overcome treatment induced sterility. Previous research demonstrated that fertility counselling has clinical and psychological benefit. Therefore, such patient services are recommended by internationally recognized guidelines. Around 70-75% of young cancer survivors in retrospective studies are reported to desire parenthood but the numbers of patients who use fertility preservation services prior treatment are significantly lower. Moreover, despite existing guidelines healthcare professionals worldwide lack practical knowledge and have personal biases which prevent addressing fertility preservation issues adequately. Surveys of healthcare professionals report the following barriers: lack of time and knowledge about existing options, poor prognosis, and delay in treatment, patient's age, partnership status, existing children, sexual orientation and socioeconomic situation. Moreover, fertility preservation consultation is not limited to medical aspects. Patient's fears, expectations and priorities shaped by personal values have to be addressed in a light of medical necessities, realistic survival prognosis, socio-cultural environment and availability of resources. We call for a need of framework for patient centred fertility counselling with a proposal that such framework should include support in decision making which would help patients to understand medical aspects of their cancer, realistic fertility preservation options, identify their preferences based on personal values and goals. Optional support services could also include legal guidance, psychological and spiritual support and financial counselling.

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“…Indeed, it is impossible to find a PCR marker which is 100 % sensitive and specific for breast cancer cells. Ideally, a disease-specific marker should be identified for each patient, but it is not always available [9][10][11]. In our study, we selected the MGB2 gene as one of the most specific markers to detect malignant breast cells, but because of the limited quantity of ovarian tissue available for this study, we were able to assess the presence of only one gene.…”

Section: Quantitative Pcr Analysesmentioning

confidence: 99%

“…Breast cancer is the second most frequent indication (21.7 %) for ovarian tissue cryopreservation (OTC) in our department, after hematological diseases (39.9 %) [9,10]. However, the risk of reintroducing malignant cells theoretically exists with this pathology [31].…”

Section: Introductionmentioning

confidence: 99%