Duration of antifungal therapy for septic pulmonary embolism caused by <i>Candida albicans</i> from a central venous catheter: A case report

Okuno, Daisuke; Oshima, Kazuhiro; Miyazaki, Taiga; Ashizawa, Naoto; Hirayama, Tatsuro; Takazono, Takahiro; Saijo, Tomomi; Yamamoto, Kazuko; Imamura, Yoshifumi; Yamaguchi, Hiroyuki; Sakamoto, Noriho; Obase, Yasushi; Izumikawa, Koichi; Yanagihara, Katsunori; Mukae, Hiroshi

doi:10.1002/ccr3.3628

Cited by 2 publications

(2 citation statements)

References 15 publications

(21 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mechanism of surface-surface interaction dependent on hydrophobic adherence is reliant on the relative level of cell surface hydrophobicity, which could alter the initiation events for endocarditis and thrombophlebitis [48,61]. Elevated levels of associated lipids, as a result of the accompanying hyperlipidemia, could be due to plasma preexposure to either obesity-associated hyperlipidemia, or conditions of temporary drug-induced dyslipidemia [31,62].…”

Section: Discussionmentioning

confidence: 99%

Adherence of Candida albicans to fibrin-clot matrices in a rat model for type 2 diabetes

Balbina J. Plotkin,

Monika I. Konaklieva

2024

World J. Bio. Pharm. Health Sci.

View full text Add to dashboard Cite

Individuals with type 2 diabetes are at increased risk for the development of infective endocarditis and septic thrombosis. Adherence to fibrin clot matrices by Candida albicans is the initial step in initiation of the infective processes. Clots made from lean (Fa/fa) and obese (fa/fa) Zucker rat plasma were used to measure adherence of yeast grown at environmental temperature and human body temperature. Adherence to clots by C. albicans was influenced both by source of plasma and temperature of yeast growth. Amphotericin B was effective in diminishing the candidal binding to lean but not obese clots. The degree of fungal surface hydrophobicity did not correlate with adherence to clots. However, Candida adherence to clots from both lean and obese Zucker rats was inhibited by the pretreatment of cells with mannose. These findings indicate that treatment of thrombi-associated candidal infections with ergosterol-targeting drugs e.g., amphotericin B alone in hypercholesterolemic individuals may have decreased clinically efficacy.

show abstract

Section: Discussionmentioning

confidence: 99%

Adherence of Candida albicans to fibrin-clot matrices in a rat model for type 2 diabetes

Balbina J. Plotkin,

Monika I. Konaklieva

2024

World J. Bio. Pharm. Health Sci.

View full text Add to dashboard Cite

show abstract

“…The risk factors for candidemia include old age, broad-spectrum antibiotics, gastrointestinal surgery, central venous catheter and total parenteral nutrition. The international guidelines recommend 2 weeks of antifungal therapy after documented Candida spp from the bloodstream and resolution of the symptoms, but the proper duration of the intravenous therapy and step down to oral therapy has not been decided yet [ 89 ]. It is recommended that patients with risk factors for fungal infections receive antifungal drugs empirically to avoid poor prognosis [ 88 ].…”

Section: Septic Embolismmentioning

confidence: 99%

Nontrombotic Pulmonary Embolism: Different Etiology, Same Significant Consequences

Sîrbu

Șorodoc

Floria

et al. 2023

JPM

View full text Add to dashboard Cite

Nontrombotic pulmonary embolism represents the embolization of different types of materials (cells, organisms, gas, foreign material) into pulmonary circulation. The disease is uncommon, and clinical presentation together with laboratory findings are nonspecific. Its pathology is usually misdiagnosed based on imaging findings as pulmonary thromboembolism, but the correct diagnosis is essential because different therapeutic approaches are required. In this context, knowledge of the risk factors associated with nontrombotic pulmonary embolism and specific clinical symptoms is fundamental. Our objective was to discuss the specific features of the most common etiologies of nontrombotic pulmonary embolism, gas, fat, amniotic fluid, sepsis and tumors, to provide assistance for a rapid and correct diagnosis. Because the most common etiologies are iatrogenic, knowledge of the risk factors could be an important tool for prevention or rapid treatment if the disease develops during different procedures. The diagnosis of nontrombotic pulmonary embolisms represent a laborious challenge, and endeavors should be made to prevent development and increase awareness of this disease.

show abstract

Duration of antifungal therapy for septic pulmonary embolism caused by Candida albicans from a central venous catheter: A case report

Abstract: The treatment duration for candidemia with septic pulmonary embolism should be determined based on the clearance of fungus from the bloodstream and improvement of symptoms. The remaining lung nodules may not necessarily indicate persistent infection.

Cited by 2 publications

References 15 publications

Adherence of Candida albicans to fibrin-clot matrices in a rat model for type 2 diabetes

Adherence of Candida albicans to fibrin-clot matrices in a rat model for type 2 diabetes

Nontrombotic Pulmonary Embolism: Different Etiology, Same Significant Consequences

Contact Info

Product

Resources

About