Dual temperature- and pH-responsive ibuprofen delivery from poly(N-isopropylacrylamide-co-acrylic acid) nanoparticles and their fractal features

Jin, Xiaoqi; Wang, Qian; Sun, Jihong; Panezail, Hamida; Wu, Xia; Bai, Shiyang

doi:10.1007/s00289-017-1915-4

Cited by 26 publications

(11 citation statements)

References 52 publications

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“…The DOX-loaded hollow nanogels showed a cytotoxic effect comparable to free drug with less toxicity and the potential for anticancer treatment [135]. In another study, Jin et al [136] demonstrated the druv-release properties of ibuprofen (IBU) from poly(Nisopropylacrylamide-co-acrylic acid) P(NIPAM-co-AA) nanogels depending on the copolymer composition, swelling characteristics and dispersion state under different conditions. Due to the electrostatic repulsion and hydrophilicity they showed high cumulative release in response to pH 7.4 (pH value higher than pK a of AA) and a temperature of 37 °C.…”

Section: Multi-stimuli Responsive Nanogelsmentioning

confidence: 99%

Stimulus-responsive polymeric nanogels as smart drug delivery systems

et al. 2019

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Nanogels are three-dimensional nanoscale networks formed by physically or chemically crosslinking polymers. Nanogels have been explored as drug delivery systems due to their advantageous properties, such as biocompatibility, high stability, tunable particle size, drug loading capacity, and possible modification of the surface for active targeting by attaching ligands that recognize cognate receptors on the target cells or tissues. Nanogels can be designed to be stimulus responsive, and react to internal or external stimuli such as pH, temperature, light, redox, thus resulting in the controlled release of loaded drug. This "smart" targeting ability prevents drug accumulation in non-target tissues and minimizes the side effects of the drug. This review aims to provide an introduction to nanogels, their preparation methods, and to discuss the design of various stimulus-responsive nanogels that are able to provide controlled drug release in response to particular stimuli.

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Section: Multi-stimuli Responsive Nanogelsmentioning

confidence: 99%

Stimulus-responsive polymeric nanogels as smart drug delivery systems

et al. 2019

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“…104 More broadly, stimuli-responsive microgels are commonly utilised as biomaterials due to their typically good biocompatibility and permeability, indicating suitability for tissue engineering and drug delivery applications. [105][106][107][108] The stimuli-responsive NP aggregation behaviour can be used to produce a (semi-) solid material that can be injected into the body in a minimally invasion manner. Our group recently utilised dual stimuli-responsive PNIPAM microgels with solid drug NPs to produce an in situ forming implant (ISFI).…”

Section: Nanomedicinementioning

confidence: 99%

Multi-stimuli-responsive aggregation of nanoparticles driven by the manipulation of colloidal stability

et al. 2021

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“…In this particular context, stimuli-responsive hydrogels have been examined as promising candidates [2,9,10] in detail during the past decades concerning their uptake and release ability of different kinds of molecules [11,12]. Besides ibuprofen and other drugs, also many surfactants were investigated due to their tunable interactions with microgel particles [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…Practically, another well-studied microgel system consisting of poly-N-isopropylmethacrylamide (PNIPMAM) exhibits a much higher VPTT of around 44 • C [23]. However, the basic principle behind all studies introducing stimuliresponsive microgels as drug delivery materials is to make use of this outstanding phase transition behavior by encapsulating drugs in either the swollen or collapsed state and afterwards releasing the drug by crossing the VPTT in the respective direction [12].…”

Section: Introductionmentioning

confidence: 99%

Smart microgels as drug delivery vehicles for the natural drug aescin: uptake, release and interactions

et al. 2020

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In the present study, we show how acrylamide-based microgels can be employed for the uptake and release of the drug β-aescin, a widely used natural product with a variety of pharmacological effects. We show how aescin is incorporated into the microgel particles. It has an important influence on the structure of the microgels, by reducing their natural network-density gradient in the swollen state. Moreover, temperature-dependent measurements reveal how the incorporation of aescin stabilizes the microgel particles, while the volume phase transition temperature (VPTT) is almost constant, which is very important for the intended drug release. Finally, it is shown that upon increase of the temperature above the VPTT the particles are able to release aescin from their network, encouraging the use of this particular drug delivery system for hypothermia treatments.

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Dual temperature- and pH-responsive ibuprofen delivery from poly(N-isopropylacrylamide-co-acrylic acid) nanoparticles and their fractal features

Cited by 26 publications

References 52 publications

Stimulus-responsive polymeric nanogels as smart drug delivery systems

Stimulus-responsive polymeric nanogels as smart drug delivery systems

Multi-stimuli-responsive aggregation of nanoparticles driven by the manipulation of colloidal stability

Smart microgels as drug delivery vehicles for the natural drug aescin: uptake, release and interactions

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