Stimulus-responsive polymeric nanogels as smart drug delivery systems

Hajebi, Sakineh; Rabiee, Navid; Bagherzadeh, Mojtaba; Ahmadi, Sepideh; Rabiee, Mohammad; Roghani‐Mamaqani, Hossein; Tahriri, Mohammadreza; Tayebi, Lobat; Hamblin, Michael R.

doi:10.1016/j.actbio.2019.05.018

Cited by 274 publications

(152 citation statements)

References 142 publications

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“…DOX, as a hydrophilic model drug, is generally used to investigate the encapsulation and delivery properties of various nanogels [82]. The drug entrapping and controlled release could be easily fulfilled by swelling-collapse variation in the presence of environmental stimuli [83]. In addition to the hydrophilic molecules, some hydrophobic drugs could also be entrapped in the nanogel network.…”

Section: Small-molecule Deliverymentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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Nanogel-based nanoplatforms have become a tremendously promising system of drug delivery. Nanogels constructed by chemical crosslinking or physical self-assembly exhibit the ability to encapsulate hydrophilic or hydrophobic therapeutics, including but not limited to small-molecule compounds and proteins, DNA/RNA sequences, and even ultrasmall nanoparticles, within their 3D polymer network. The nanosized nature of the carriers endows them with a specific surface area and inner space, increasing the stability of loaded drugs and prolonging their circulation time. Reactions or the cleavage of chemical bonds in the structure of drug-loaded nanogels have been shown to trigger the controlled or sustained drug release. Through the design of specific chemical structures and different methods of production, nanogels can realize diverse responsiveness (temperature-sensitive, pH-sensitive and redox-sensitive), and enable the stimuli-responsive release of drugs in the microenvironments of various diseases. To improve therapeutic outcomes and increase the precision of therapy, nanogels can be modified by specific ligands to achieve active targeting and enhance the drug accumulation in disease sites. Moreover, the biomembrane-camouflaged nanogels exhibit additional intelligent targeted delivery features. Consequently, the targeted delivery of therapeutic agents, as well as the combinational therapy strategy, result in the improved efficacy of disease treatments, though the introduction of a multifunctional nanogel-based drug delivery system.

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Section: Small-molecule Deliverymentioning

confidence: 99%

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

et al. 2020

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“…Due to their peculiar structures, they offer great possibilities for the coating of nanoparticles and drug delivery/selectivity enhancement. When located on a particle's surface they are able to give them specific properties and functionalities: the surface modification is in fact crucial for the biological response and to improve the therapeutic efficiency [77][78][79]. Examples of polymers that can be used include polyethylene glycol, polycaprolactone, polysorbate, polylactic acid, dextran, chitosan, and many others [78][79][80][81].…”

Section: Polymersmentioning

confidence: 99%

Coating and Functionalization Strategies for Nanogels and Nanoparticles for Selective Drug Delivery

Pinelli

Perale

Rossi

2020

Gels

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Drug delivery is a fascinating research field with several development opportunities. Great attention is now focused on colloidal systems, nanoparticles, and nanogels and on the possibility of modifying them in order to obtain precise targeted drug delivery systems. The aim of this review is to give an overview of the main available surface functionalization and coating strategies that can be adopted in order to modify the selectivity of the nanoparticles in the delivery process and obtain a final system with great targeted drug delivery ability. We also highlight the most important fields of application of these kinds of delivery systems and we propose a comparison between the advantages and disadvantages of the described functionalization strategies.

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“…The porous network resulting from the cross-linking allows for high drug entrapment efficiency. The advantages of using nanogels in comparison to the free drug are enhanced drug stability, prolonged blood circulation time, and the possibility to respond to specific stimuli to obtain drug release (pH, magnetic field, light, ionic content, and temperature) [51]. Moreover, their high water content and living tissue-like physical properties ensure high biocompatibility.…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Nanocarriers as Magic Bullets in the Treatment of Leukemia

et al. 2020

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Leukemia is a type of hematopoietic stem/progenitor cell malignancy characterized by the accumulation of immature cells in the blood and bone marrow. Treatment strategies mainly rely on the administration of chemotherapeutic agents, which, unfortunately, are known for their high toxicity and side effects. The concept of targeted therapy as magic bullet was introduced by Paul Erlich about 100 years ago, to inspire new therapies able to tackle the disadvantages of chemotherapeutic agents. Currently, nanoparticles are considered viable options in the treatment of different types of cancer, including leukemia. The main advantages associated with the use of these nanocarriers summarized as follows: i) they may be designed to target leukemic cells selectively; ii) they invariably enhance bioavailability and blood circulation half-life; iii) their mode of action is expected to reduce side effects. FDA approval of many nanocarriers for treatment of relapsed or refractory leukemia and the desired results extend their application in clinics. In the present review, different types of nanocarriers, their capability in targeting leukemic cells, and the latest preclinical and clinical data are discussed.

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Stimulus-responsive polymeric nanogels as smart drug delivery systems

Cited by 274 publications

References 142 publications

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Nanogel: A Versatile Nano-Delivery System for Biomedical Applications

Coating and Functionalization Strategies for Nanogels and Nanoparticles for Selective Drug Delivery

Nanocarriers as Magic Bullets in the Treatment of Leukemia

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