Coating and Functionalization Strategies for Nanogels and Nanoparticles for Selective Drug Delivery

Pinelli, Filippo; Perale, Giuseppe; Rossi, Filippo

doi:10.3390/gels6010006

Cited by 76 publications

(64 citation statements)

References 94 publications

(113 reference statements)

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“…It has been noticed that also polymeric nanogels show the minimum level of toxicity, stability in the presence of serum, and stimulus responsiveness, since they possess a high drug encapsulation capacity, tuneable size and are relatively easy to obtain. Therefore, they are widely used in biosensors, drug delivery, tissue engineering, and biomimetic materials design [113,114].…”

Section: In Vitro and Vivo Toxicological Studiesmentioning

confidence: 99%

Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

et al. 2020

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Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term “nanoparticle” stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases. In this review, we discuss the most commonly used methods for the production and characterization of polymeric NPs, the association efficiency of the active compound to the polymeric core, and the in vitro release mechanisms. As the safety of nanoparticles is a high priority, we also discuss the toxicology and ecotoxicology of nanoparticles to humans and to the environment.

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Section: In Vitro and Vivo Toxicological Studiesmentioning

confidence: 99%

Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

et al. 2020

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“…Commonly, hydrophilic functionalities such as acid, amine, ester, alcohol are mostly preferred (Figure 3b). Many approaches are used to functionalize the metal surface, as schematized in Figure 3a: (a) the ligand exchange strategy; (b) stabilization during the synthesis with a ligand with sulfur or nitrogen; (c) stabilization during the synthesis with two or more ligands; (d) stabilization during the synthesis with ligands with more functional groups [35,47,[76][77][78]. The first approach, ligand exchange, is the simplest and most economic way to functionalize the silver surface.…”

Section: Synthesis Of Agnps Used For Water Protection Applicationsmentioning

confidence: 99%

Silver Nanoparticles as Colorimetric Sensors for Water Pollutants

2020

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This review provides an up-to-date overview on silver nanoparticles-based materials suitable as optical sensors for water pollutants. The topic is really hot considering the implications for human health and environment due to water pollutants. In fact, the pollutants present in the water disturb the spontaneity of life-related mechanisms, such as the synthesis of cellular constituents and the transport of nutrients into cells, and this causes long / short-term diseases. For this reason, research continuously tends to develop always innovative, selective and efficient processes / technologies to remove pollutants from water. In this paper we will report on the silver nanoparticles synthesis, paying attention to the stabilizers and mostly used ligands, to the characterizations, to the properties and applications as colorimetric sensors for water pollutants. As water pollutants our attention will be focused on several heavy metals ions, such as Hg(II), Ni(II),Cu(II), Fe(III), Mn(II), Cr(III/V) Co(II) Cd(II), Pb(II), due to their dangerous effects on human health. In addition, several systems based on silver nanoparticles employed as pesticides colorimetric sensors in water will be also discussed. All of this with the aim to provide to readers a guide about recent advanced silver nanomaterials, used as colorimetric sensors in water.

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“…The loading profile ( Figure 4 ) shows the rapid adsorption of VBL, followed by the slowing of the adsorption rate 90 min later because the surface of the nanoparticles was covered by VBL [ 23 ]. This may be attributed to the type of core-shell structure and the presence of polymer provides several functional groups for a more significant interaction with drug molecules on the drug delivery system’s surface [ 24 ]. Based on the in vitro release curves shown in Figure 5 , the VBL release time from loaded FA-DEX-SPION occurred over 96 h, and the release rate was faster in citrate buffer (with an acidic pH of 5.4) compared with phosphate buffer (with a normal pH of 7.4) under the same conditions.…”

Section: Resultsmentioning

confidence: 99%

Investigation of Dextran-Coated Superparamagnetic Nanoparticles for Targeted Vinblastine Controlled Release, Delivery, Apoptosis Induction, and Gene Expression in Pancreatic Cancer Cells

Albukhaty

Al-Musawi²,

Mahdi³

et al. 2020

Molecules

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In the current study, the surface of superparamagnetic iron oxide (SPION) was coated with dextran (DEX), and conjugated with folic acid (FA), to enhance the targeted delivery and uptake of vinblastine (VBL) in PANC-1 pancreatic cancer cells. Numerous analyses were performed to validate the prepared FA-DEX-VBL-SPION, such as field emission scanning transmission electron microscopy, high-resolution transmission electron microscopy, dynamic light scattering (DLS), Zeta Potential, Fourier transform infrared spectroscopy, and vibrating sample magnetometry (VSM). The delivery system capacity was evaluated by loading and release experiments. Moreover, in vitro biological studies, including a cytotoxicity study, cellular uptake assessment, apoptosis analysis, and real-time PCR, were carried out. The results revealed that the obtained nanocarrier was spherical with a suitable dispersion and without visible aggregation. Its average size, polydispersity, and zeta were 74 ± 13 nm, 0.080, and −45 mV, respectively. This dual functional nanocarrier also exhibited low cytotoxicity and a high apoptosis induction potential for successful VBL co-delivery. Real-time quantitative PCR analysis demonstrated the activation of caspase-3, NF-1, PDL-1, and H-ras inhibition, in PANC-1 cells treated with the FA-VBL-DEX-SPION nanostructure. Close inspection of the obtained data proved that the FA-VBL-DEX-SPION nanostructure possesses a noteworthy chemo-preventive effect on pancreatic cancer cells through the inhibition of cell proliferation and induction of apoptosis.

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Coating and Functionalization Strategies for Nanogels and Nanoparticles for Selective Drug Delivery

Cited by 76 publications

References 94 publications

Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

Silver Nanoparticles as Colorimetric Sensors for Water Pollutants

Investigation of Dextran-Coated Superparamagnetic Nanoparticles for Targeted Vinblastine Controlled Release, Delivery, Apoptosis Induction, and Gene Expression in Pancreatic Cancer Cells

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