Dual stimuli-responsive nanoplatform based on core-shell structured graphene oxide/mesoporous silica@alginate

Li, Shangji; Cao, Cheng; Gao, Jun; Li, Kelin; Kang, Jing; Wu, Datong; Kong, Yong

doi:10.1016/j.ijbiomac.2021.02.021

Cited by 26 publications

(6 citation statements)

References 33 publications

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“…Note that the peak at around 2560 cm −1 due to the stretching vibration of S−H is not detectable in the spectrum of MPA-CdSe QDs, suggesting that MPA might be covalently bound to the surface of CdSe QDs through S−H. 27,33 In the case of NH 2 -TiNTs, the weak peak at around 1560 cm −1 can be assigned to the bending vibration of N−H, 34 while other two peaks at 1630 and 500 cm −1 correspond to the O−H bond and Ti−O bond from TiNTs, 30 respectively. All the characteristic peaks of MPA-CdSe QDs and NH 2 -TiNTs can be observed in the spectrum of CdSe QDs/TiNTs, implying its successful synthesis.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

TiO₂ Nanotubes Decorated with CdSe Quantum Dots: A Bifunctional Electrochemiluminescent Platform for Chiral Discrimination and Chiral Sensing

et al. 2022

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Chiral analysis is of significant importance for living organisms since chirality is the fundamental phenomenon in nature. In this work, a bifunctional electrochemiluminescent (ECL) platform is constructed for chiral discrimination and chiral sensing. 3-Mercaptopropionic acid-functionalized CdSe quantum dots (CdSe QDs) are combined with aminated TiO2 nanotubes (NH2-TiNTs) via amidation. The resultant CdSe QDs/TiNTs display significantly enhanced ECL signals due to the synergistic effect between CdSe QDs and TiNTs, which are then used for the chiral discrimination of the isomers of nine chiral amino acids (AAs) in the presence of d-AA oxidase (DAAO). DAAO can selectively catalyze the oxidation of d-AAs to generate H2O2, which acts as the coreaction reagent and triggers the ECL signals of CdSe QDs/TiNTs, and thus, the isomers of the nine chiral AAs can be effectively discriminated. In addition, the as-constructed ECL platform can also be used for the sensitive detection of d-AAs in the presence of DAAO with a wide linear range and a low limit of detection. These findings suggest that the CdSe QDs/TiNTs can work as a bifunctional ECL platform (chiral discrimination and chiral sensing), which might be an advanced ECL platform for biomedical applications.

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Section: ■ Results and Discussionmentioning

confidence: 99%

TiO₂ Nanotubes Decorated with CdSe Quantum Dots: A Bifunctional Electrochemiluminescent Platform for Chiral Discrimination and Chiral Sensing

et al. 2022

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“…[260][261][262][263][264] Surface-functionalized modifications of MSNs not only offer unique advantages in terms of improved biosafety, long circulation and targeting ability, but can also be used to construct intelligent stimuli-responsive drug delivery systems. [265][266][267][268][269] Once they reach the lesion sites, the spatial and temporal controlled release of drugs in response to stimuli such as pH, 270,271 temperature, 272,273 light [274][275][276] and ultrasound 277,278 can be achieved. We next will describe the purpose of surface functionalization of MSNs.…”

Section: Surface Functionalizationmentioning

confidence: 99%

Multifunctional mesoporous silica nanoparticles for biomedical applications

Xu,

Li,

Shi

et al. 2023

Sig Transduct Target Ther

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Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, and excellent biocompatibility. Over the past two decades, researchers have developed a wide variety of MSNs-based nanoplatforms through careful design and controlled preparation techniques, demonstrating their adaptability to various biomedical application scenarios. With the continuous breakthroughs of MSNs in the fields of biosensing, disease diagnosis and treatment, tissue engineering, etc., MSNs are gradually moving from basic research to clinical trials. In this review, we provide a detailed summary of MSNs in the biomedical field, beginning with a comprehensive overview of their development history. We then discuss the types of MSNs-based nanostructured architectures, as well as the classification of MSNs-based nanocomposites according to the elements existed in various inorganic functional components. Subsequently, we summarize the primary purposes of surface-functionalized modifications of MSNs. In the following, we discuss the biomedical applications of MSNs, and highlight the MSNs-based targeted therapeutic modalities currently developed. Given the importance of clinical translation, we also summarize the progress of MSNs in clinical trials. Finally, we take a perspective on the future direction and remaining challenges of MSNs in the biomedical field.

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“…Recently, the potential application of MSN-based photothermal therapy (PTT) and their combinational therapy in treating HCC have been explored ( Chen et al, 2015c ; Li et al, 2021a ; Yang et al, 2021 ). PTT uses the deep tissue penetration and good biocompatibility of near-infrared light (NIR 700–2500 nm) to irradiate the pathological tissue, and the photothermal material converts the light energy into heat, leading to a localized increase in temperature.…”

Section: Snf-based Hcc Therapymentioning

confidence: 99%

Silica-Based Nanoframeworks Involved Hepatocellular Carcinoma Theranostic

Liu

Chen

Fei

et al. 2021

Front. Bioeng. Biotechnol.

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Silica-based nanoframeworks have been extensively studied for diagnosing and treating hepatocellular carcinoma (HCC). Several reviews have summarized the advantages and disadvantages of these nanoframeworks and their use as drug-delivery carriers. Encouragingly, these nanoframeworks, especially those with metal elements or small molecular drugs doping into the skeleton structure or modifying onto the surface of nanoparticles, could be multifunctional components participating in HCC diagnosis and treatment rather than functioning only as drug-delivery carriers. Therefore, in this work, we described the research progress of silica-based nanoframeworks involved in HCC diagnosis (plasma biomarker detection, magnetic resonance imaging, positron emission tomography, photoacoustic imaging, fluorescent imaging, ultrasonography, etc.) and treatment (chemotherapy, ferroptotic therapy, radiotherapy, phototherapy, sonodynamic therapy, immunotherapy, etc.) to clarify their roles in HCC theranostics. Further, the future expectations and challenges associated with silica-based nanoframeworks were highlighted. We believe that this review will provide a comprehensive understanding for researchers to design novel, functional silica-based nanoframeworks that can effectively overcome HCC.

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Dual stimuli-responsive nanoplatform based on core-shell structured graphene oxide/mesoporous silica@alginate

Cited by 26 publications

References 33 publications

TiO₂ Nanotubes Decorated with CdSe Quantum Dots: A Bifunctional Electrochemiluminescent Platform for Chiral Discrimination and Chiral Sensing

TiO₂ Nanotubes Decorated with CdSe Quantum Dots: A Bifunctional Electrochemiluminescent Platform for Chiral Discrimination and Chiral Sensing

Multifunctional mesoporous silica nanoparticles for biomedical applications

Silica-Based Nanoframeworks Involved Hepatocellular Carcinoma Theranostic

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Dual stimuli-responsive nanoplatform based on core-shell structured graphene oxide/mesoporous silica@alginate

Cited by 26 publications

References 33 publications

TiO2 Nanotubes Decorated with CdSe Quantum Dots: A Bifunctional Electrochemiluminescent Platform for Chiral Discrimination and Chiral Sensing

TiO2 Nanotubes Decorated with CdSe Quantum Dots: A Bifunctional Electrochemiluminescent Platform for Chiral Discrimination and Chiral Sensing

Multifunctional mesoporous silica nanoparticles for biomedical applications

Silica-Based Nanoframeworks Involved Hepatocellular Carcinoma Theranostic

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Product

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TiO₂ Nanotubes Decorated with CdSe Quantum Dots: A Bifunctional Electrochemiluminescent Platform for Chiral Discrimination and Chiral Sensing

TiO₂ Nanotubes Decorated with CdSe Quantum Dots: A Bifunctional Electrochemiluminescent Platform for Chiral Discrimination and Chiral Sensing