2022
DOI: 10.1021/acs.analchem.2c01383
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Chiral analysis is of significant importance for living organisms since chirality is the fundamental phenomenon in nature. In this work, a bifunctional electrochemiluminescent (ECL) platform is constructed for chiral discrimination and chiral sensing. 3-Mercaptopropionic acid-functionalized CdSe quantum dots (CdSe QDs) are combined with aminated TiO2 nanotubes (NH2-TiNTs) via amidation. The resultant CdSe QDs/TiNTs display significantly enhanced ECL signals due to the synergistic effect between CdSe QDs and Ti… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
9
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 15 publications
(9 citation statements)
references
References 43 publications
0
9
0
Order By: Relevance
“…As shown in Figure F, the value of I 883 / I 998 for d -Pro is about 21-fold greater than that for l -Pro (after blank correction), while the value for d -Ala is about 20-fold greater than that for l -Ala, indicating an excellent enantiomeric selectivity and detection performance free from the interferences of l -Pro and l -Ala. What is more, other possible interferents in saliva were also checked such as KHCO 3 , CaCl 2 , NaCl, MgCl 2 , glutathione (GSH), glycine (Gly), cysteine (Cys), valine (Val), serine (Ser), threonine (Thr), peroxidase (Perid), amylase, vitamin B1 (VB1), lysozyme (LZ), phospholipase D (PLD), and α-glucosidase (α-glu). Again, in Figure F, the values of I 883 / I 998 for these species are much lower than those for d -Pro and d -Ala. As summarized in Table S1, the detection performance (linear range, LOD, and anti-interference) of the current SERS method is comparable with other fluorescence, electrochemical, colorimetric, and electrochemiluminescence methods for d -Ala and d -Pro. , Compared with these assays, our method avoids complex enzyme immobilization procedures and high-temperature (up to 900 °C) synthesis conditions in an inert atmosphere, and the saliva sample pretreatment is also simple.…”
Section: Resultsmentioning
confidence: 70%
See 1 more Smart Citation
“…As shown in Figure F, the value of I 883 / I 998 for d -Pro is about 21-fold greater than that for l -Pro (after blank correction), while the value for d -Ala is about 20-fold greater than that for l -Ala, indicating an excellent enantiomeric selectivity and detection performance free from the interferences of l -Pro and l -Ala. What is more, other possible interferents in saliva were also checked such as KHCO 3 , CaCl 2 , NaCl, MgCl 2 , glutathione (GSH), glycine (Gly), cysteine (Cys), valine (Val), serine (Ser), threonine (Thr), peroxidase (Perid), amylase, vitamin B1 (VB1), lysozyme (LZ), phospholipase D (PLD), and α-glucosidase (α-glu). Again, in Figure F, the values of I 883 / I 998 for these species are much lower than those for d -Pro and d -Ala. As summarized in Table S1, the detection performance (linear range, LOD, and anti-interference) of the current SERS method is comparable with other fluorescence, electrochemical, colorimetric, and electrochemiluminescence methods for d -Ala and d -Pro. , Compared with these assays, our method avoids complex enzyme immobilization procedures and high-temperature (up to 900 °C) synthesis conditions in an inert atmosphere, and the saliva sample pretreatment is also simple.…”
Section: Resultsmentioning
confidence: 70%
“…Chromatography is a common method for chiral discrimination but suffers from tedious sample pretreatment, specialized operation, and time-consuming analysis. , Alternatively, electrochemical and spectroscopic methods are of interest for convenient inspection of d -AAs. , The surface-enhanced Raman scattering (SERS) technique is appealing for biological sample analysis owing to the merits including molecule fingerprint specificity, quick signal response, high sensitivity, operational simplicity, and non-destructive testing . Normally, it is very difficult to directly distinguish enantiomers by using the SERS method because of their similar Raman-active vibration signals from l -form and d -form enantiomers.…”
Section: Introductionmentioning
confidence: 99%
“…The lifetime of the three EMs hardly changes with the existence of protein (Figures S6b−d). Furthermore, a molecular docking simulation 35 is performed to verify and explore the interaction force between the ligands (H 2 BDC, H 3 BTC) of EMs and proteins (taking HSA as an example). Figure S6e demonstrates that there are mainly hydrogen bond interactions between H 2 BDC and amino acid residues of LYS-467, ARG-194, ASP-394, ARG-259, GLN-333, and TYR-359 of HSA.…”
Section: Identification and Determination Of Csf Proteinsmentioning
confidence: 99%
“…Chiral electrochemiluminescence (ECL) has the potential to be a powerful technique for chiral analysis as it combines the advantages of controlled electrochemical reactions and extremely sensitive detection. , However, there are relatively few studies addressing this topic. To achieve efficient chiral sensing, molecular recognition and signal transduction must be completed in a single step. , This means that it is essential to design chiral architectures to distinguish enantiomers and provide reliable transduction signals.…”
mentioning
confidence: 99%
“…To achieve efficient chiral sensing, molecular recognition and signal transduction must be completed in a single step. 11,12 This means that it is essential to design chiral architectures to distinguish enantiomers and provide reliable transduction signals.…”
mentioning
confidence: 99%