Dual-functional red-emitting fluorescent probes for imaging beta-amyloid plaques and viscosity

Tan, Hui-ya; Zhou, Kaixiang; Yan, Jin-wu; Sun, Han; Pistolozzi, Marco; Cui, Mengchao; Zhang, Lei

doi:10.1016/j.snb.2019.126903

Cited by 34 publications

(16 citation statements)

References 41 publications

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“…Fluorescence imaging data demonstrated that probe 71 could accumulate into lysosomes and indicate the increase of viscosity induced by low temperature and dexamethasone. The same group also constructed a series of merocyanine dye derivatives for the detection of beta‐amyloid plaques and viscosity [101] . Among them, a selected fluorescent probe 72 was utilized to image the viscosity rise in live cells treated with monensin and nystatin (Figure 33).…”

Section: Small Molecular Fluorescent Probes For Viscositymentioning

confidence: 99%

Small Molecular Fluorescent Probes for Imaging of Viscosity in Living Biosystems

Xiao

Tang

2021

Chemistry A European J

110

115

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Viscosity, as a vital microenvironment parameter, is tightly associated with multitudinous cellular processes and diseases. Recently, precise visualization of viscosity has started to arouse more and more interest. However, owing to the complicated character, it is still a huge challenge to directly observe viscosity in living systems. In this regard, mounting fluorescence probes are being increasingly fabricated to map viscosity inside live cells and small animals. In this minireview, the viscosity‐sensitive small molecular fluorescent probes used in bioimaging are comprehensively summarized, mainly focusing on the last three years. Moreover, the current challenges and opportunities for the development of viscosity‐specific fluorescent probes will be discussed.

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Section: Small Molecular Fluorescent Probes For Viscositymentioning

confidence: 99%

Small Molecular Fluorescent Probes for Imaging of Viscosity in Living Biosystems

Xiao

Tang

2021

Chemistry A European J

110

115

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“…injection of probe 124 at a dosage level of 0.1 mg kg −1 into 10 months old AD Tg (APPswe/PSEN1) and WT mice, the dynamic NIR fluorescence images suggested the increased Aβ plaques level in Tg mice (Figure 21B). [ 163 ] The same research group also reported a lysosome‐targeted dual‐functional fluorescent probe for the detection of intracellular lysosomal viscosity and Aβ by introducing a 3‐morpholinopropylamine moiety to the MC‐1, thereby generating probe 125 (Lyso‐MC, Figure 21C). Probe 125 was also applied to detect the lysosomal viscosity in SH‐SY5Y cells and Aβ plaques in transfected PC12 (PC12‐EGFP‐Aβ) cells.…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Section: Alzheimer's Diseasementioning

confidence: 99%

Fluorescent Diagnostic Probes in Neurodegenerative Diseases

et al. 2020

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Both chronic and acute neurodegenerative diseases have been associated with high morbidity and mortality, along with the death of neurons in different areas of the brain, and there are few or no effective curative therapy options for treatment of patients. [3,4] These disorders are a major cause of concern for the health and quality of life in the aging society, since age is the greatest risk factor for neurodegenerative disease. [5] The World Health Organization has predicted that in next 20 years neurodegenerative disease will become the second most common cause of mortality after cardiovascular disease. [6] Neurodegenerative processes begin long before their clinical symptoms are evident, and evolve for years slowly and irreversibly. Hence, there is an urgent need to diagnose neurodegenerative disease as early as possible and to distinguish between different neurodegenerative disorders with shared and unique symptoms to facilitate decision making regarding choice of treatment. Timely diagnosis is important for the adoption of therapeutic modalities in clinical trials prior to moderate dementia exhibition, to appraise and apply antidotes to maximally preserve the cognitive functions or to slow down the course of these disorders. The ability to analyze and identify risk factors for cognitive deficit would represent an extraordinary advancement in the field of dementia. [5] The main modern diagnostic technologies for the early examination of neurodegenerative disease pathology, neuroimaging techniques, include radioligandsbased positron emission tomography (PET), 3D single-photon emission-computed tomography (SPECT), and structural magnetic resonance imaging (MRI). Although PET and SPECT are the most used imaging techniques for neurodegenerative diseases, their application is limited by high cost, involvement of hazardous radiolabeled compounds, need for sophisticated instruments, and application of complex data acquisition and analysis protocols. The MRI technique has relatively low spatial resolution as well as intrinsically poor sensitivity to distinguish morphological differences between disease biomarkers and the surrounding tissue. Recently, fluorescence diagnosis technology has become an attractive and potential alternative to diagnose and probe the progression of neurodegenerative diseases, because of being rapid, noninvasive, sensitive, simple, real-time, low-cost, and high-resolution in nature. [7] There are several uses for Neurodegenerative diseases are debilitating disorders that feature progressive and selective loss of function or structure of anatomically or physiologically associated neuronal systems. Both chronic and acute neurodegenerative diseases are associated with high morbidity and mortality along with the death of neurons in different areas of the brain; moreover, there are few or no effective curative therapy options for treating these disorders. There is an urgent need to diagnose neurodegenerative disease as early as possible, and to distinguish between different disorders with overlap...

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“…However, due to its slow onset and insidiousness, the appearance of symptoms often lags behind the course of the disease 15 . The development of non-invasive, real-time, rapid and reliable strategies for AD is of great urgence for early diagnosis and treatment of AD 17 . Direct detection of Aβ levels and changes provides the most reliable and direct information for AD diagnosis 18 , 19 .…”

Section: Introductionmentioning

confidence: 99%

Advances in aptamers against Aβ and applications in Aβ detection and regulation for Alzheimer's disease

Zheng¹,

Zhang²,

Zhao³

et al. 2022

Theranostics

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Alzheimer's disease (AD) is an irreversible neurodegenerative disease, causing profound social and economic implications. Early diagnosis and treatment of AD have faced great challenges due to the slow and hidden onset. β-amyloid (Aβ) protein has been considered an important biomarker and therapeutic target for AD. Therefore, non-invasive, simple, rapid and real-time detection methods for AD biomarkers are particularly favored. With the development of Aβ aptamers, the specific recognition between aptamers and Aβ plays a significant role in AD theranostics. On the one hand, aptamers are applied to construct biosensors for Aβ detection, which provides possibilities for early diagnosis of AD. On the other hand, aptamers are used for regulating Aβ aggregation process, which provides potential strategies for AD treatment. Many excellent reviews have summarized aptamers for neurodegenerative diseases or biosensors using specific recognition probes for Aβ detection applications in AD. In this review, we highlight the crucial role of the design, classification and applications of aptamers on Aβ detection as well as inhibition of Aβ aggregation for AD.

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Dual-functional red-emitting fluorescent probes for imaging beta-amyloid plaques and viscosity

Cited by 34 publications

References 41 publications

Small Molecular Fluorescent Probes for Imaging of Viscosity in Living Biosystems

Small Molecular Fluorescent Probes for Imaging of Viscosity in Living Biosystems

Fluorescent Diagnostic Probes in Neurodegenerative Diseases

Advances in aptamers against Aβ and applications in Aβ detection and regulation for Alzheimer's disease

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